DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr1 and IGSF9

DIOPT Version :9

Sequence 1:	NP_001286645.1	Gene:	dpr1 / 2768858	FlyBaseID:	FBgn0040726	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens

Alignment Length:	340	Identity:	79/340 - (23%)
Similarity:	114/340 - (33%)	Gaps:	101/340 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 WLIGWLLLLSMVLLRGYNAALAP------------------------TPPTTSTTTISPSNLLPY 54
            |.:| |.:||:|:.:|.:....|                        .||......:....|||.
Human     3 WCLG-LAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPI 66

  Fly    55 F-DFDV--PRNLTVTVG----QTGFLHCRVERLGDKDVSWIRKR----DLHILT---AGGT---- 101
            | .|.:  ||.....||    |.| ...::|.|..:|..|...|    |.||..   |.|:
Human    67 FIQFGLYSPRIDPDYVGRVRLQKG-ASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHL 130

  Fly   102 TYTSDQRFQVLRP-----------------DGS-----------------------ANWTLQIKY 126
            |..|..:||...|                 .||                       .|.||:|:.
Human   131 TVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRR 195

  Fly   127 PQPRDSGVYECQI-NTEPKMSLSYTFNVVELKAEIFGPSDLMVKTGSDINLTCKIMQGPHELGNI 190
            .:...||||.||. :||...:.:....|:.....:..|.:..|....|::|.|.....|..| ..
Human   196 VERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANL-TY 259

  Fly   191 FWYKGSEMLDGKGENEIDSSMARIRVEDDWTDGLTSRLKIKRAMPGDTGNYTCVPTVA----KTS 251
            .|::     |......|.....|:|:   ..||   .|::....|.|.|.|||||:..    .::
Human   260 SWFQ-----DNINVFHISRLQPRVRI---LVDG---SLRLLATQPDDAGCYTCVPSNGLLHPPSA 313

  Fly   252 SVYVHVIIGEHPAAM 266
            |.|:.|:......||
Human   314 SAYLTVLYPAQVTAM 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr1	NP_001286645.1	Ig	59..154	CDD:299845	35/152 (23%)
		IG_like	60..150	CDD:214653	35/145 (24%)
		IG_like	163..257	CDD:214653	25/97 (26%)
		Ig	174..244	CDD:143165	17/69 (25%)
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845	24/108 (22%)
		IG_like	28..110	CDD:214653	17/82 (21%)
		I-set	136..223	CDD:254352	17/86 (20%)
		Ig	154..220	CDD:143165	14/65 (22%)
		Ig_3	226..305	CDD:290638	23/90 (26%)
		IG_like	233..319	CDD:214653	25/97 (26%)
		Ig	341..404	CDD:299845
		IG_like	431..503	CDD:214653
		Ig	436..500	CDD:143165
		fn3	511..596	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810