DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpr1 and SDK2

DIOPT Version :9

Sequence 1:NP_001286645.1 Gene:dpr1 / 2768858 FlyBaseID:FBgn0040726 Length:367 Species:Drosophila melanogaster
Sequence 2:NP_001138424.1 Gene:SDK2 / 54549 HGNCID:19308 Length:2172 Species:Homo sapiens


Alignment Length:330 Identity:66/330 - (20%)
Similarity:107/330 - (32%) Gaps:117/330 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 LLRG-YNAALAPTPPTTSTTTISPSNLLPYFDFDVPRNLTVTVGQTGFLHCRVERLGDKDVSWIR 89
            ::|| |.:.|.|                |.|..:..|::|..:.:...:.|:.:.:....::|. 
Human   296 VVRGAYLSVLEP----------------PQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWY- 343

  Fly    90 KRDLHILTAGGTTYTSDQRFQVLRPDGSANWTLQIKYPQPRDSGVYEC-QINTEPKMSLSYTFNV 153
             :|..::.....|     ||: .|.||.    |||....|.|:|:::| ..|...::..|....|
Human   344 -KDAAVVEVEKLT-----RFR-QRNDGG----LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAV 397

  Fly   154 VELKAEIF-GPSDLMVKTGSDINLTCKIMQGPHELGNIFWYKGSEML------------------ 199
            ..:...|. ||.|..|..|..:.|.|:....|...  |.|.||..:|                  
Human   398 TSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPA--ITWQKGERILASGSVQLPRFTPLESGSL 460

  Fly   200 ------------------DGKGENEIDSSM---ARIRV----EDD-------------------- 219
                              :.:|.:|..:.:   ||.|:    :|.                    
Human   461 LISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRV 525

  Fly   220 -----W-TDGLT--------------SRLKIKRAMPGDTGNYTC-VPTVAKTSSVYVHVIIGEHP 263
                 | .||.|              ..|.|.:...||.|.||| |.:.....|...|:.:.:.|
Human   526 TIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLP 590

  Fly   264 AAMQH 268
            .|.:|
Human   591 HAPEH 595

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr1NP_001286645.1 Ig 59..154 CDD:299845 20/95 (21%)
IG_like 60..150 CDD:214653 20/90 (22%)
IG_like 163..257 CDD:214653 32/177 (18%)
Ig 174..244 CDD:143165 26/153 (17%)
SDK2NP_001138424.1 Ig 27..109 CDD:299845
IG_like 40..109 CDD:214653
I-set 120..203 CDD:254352
Ig 132..210 CDD:299845
IG_like 222..304 CDD:214653 3/7 (43%)
IGc2 233..286 CDD:197706
I-set 308..397 CDD:254352 22/100 (22%)
Ig 326..394 CDD:143165 18/79 (23%)
I-set 402..492 CDD:254352 16/91 (18%)
Ig 416..492 CDD:299845 11/77 (14%)
Ig 502..586 CDD:299845 16/83 (19%)
IG_like 502..586 CDD:214653 16/83 (19%)
FN3 590..681 CDD:238020 3/6 (50%)
FN3 693..786 CDD:238020
FN3 794..890 CDD:238020
FN3 895..983 CDD:238020
FN3 993..1087 CDD:238020
FN3 1099..1194 CDD:238020
FN3 1201..1290 CDD:238020
FN3 1301..1394 CDD:238020
FN3 1400..1484 CDD:238020
FN3 1503..1616 CDD:238020
FN3 1626..1719 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1707..1729
FN3 1724..1805 CDD:238020
FN3 1837..1916 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2039..2067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2098..2172
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2166..2172
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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