DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr1 and Lrig2

DIOPT Version :9

Sequence 1:	NP_001286645.1	Gene:	dpr1 / 2768858	FlyBaseID:	FBgn0040726	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_001101180.1	Gene:	Lrig2 / 310753	RGDID:	1309554	Length:	1054	Species:	Rattus norvegicus

Alignment Length:	250	Identity:	56/250 - (22%)
Similarity:	97/250 - (38%)	Gaps:	37/250 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 NLLPYFDFDVPRNLTVTVGQTGFLHCRVERLGDKDVSWIRKRDLHILTAGGTTYTS--DQRFQVL 112
            |.:|.| ...|.:||:..|....|.|..|......:||  ::|      |||.:.:  ::|..|:
  Rat   598 NEMPSF-LKTPMDLTIRTGAMARLECAAEGHPTPQISW--QKD------GGTDFPAARERRMHVM 653

  Fly   113 RPDGSANWTLQIKYPQPRDSGVYECQI-NTEPKMSLSYTFNVVELKAEIFGPSDLMVKTGSDINL 176
             |:....:...:|.   .|.|:|.|.. |....:|.:.:..|:|..:.|....|..|..|....|
  Rat   654 -PEDDVFFIANVKI---EDMGIYSCMAQNIAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVL 714

  Fly   177 TCKIMQGPHELGNIFWYKGSEMLDGKGENEIDSSMARIRVEDDWTDGLTSRLKIKRAMPGDTGNY 241
            .|  :.|......:.|.|....|              :..|..:.......|.|..|...|.|.|
  Rat   715 QC--IAGGSPAPRLNWTKDDGPL--------------LVTERHFFAAANQLLIIVDAGLEDAGKY 763

  Fly   242 TCVPT---VAKTSSVYVHVIIGEHPAAMQHNSSSNSNSFYCGICCMLLSIVSCCL 293
            ||:.:   ..:...:|::||...:..:.| ||..:.:..:..:..::: :|.||:
  Rat   764 TCLMSNTLGTERGHIYLNVISSPNCDSSQ-NSIGHEDDGWTTVGIVII-VVVCCV 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr1	NP_001286645.1	Ig	59..154	CDD:299845	23/97 (24%)
		IG_like	60..150	CDD:214653	23/92 (25%)
		IG_like	163..257	CDD:214653	19/96 (20%)
		Ig	174..244	CDD:143165	14/69 (20%)
Lrig2	NP_001101180.1	LRR_RI	<50..204	CDD:238064
		leucine-rich repeat	98..120	CDD:275380
		LRR_8	119..178	CDD:290566
		leucine-rich repeat	121..144	CDD:275380
		LRR_RI	136..398	CDD:238064
		leucine-rich repeat	145..167	CDD:275380
		LRR_8	167..226	CDD:290566
		leucine-rich repeat	168..192	CDD:275380
		leucine-rich repeat	193..215	CDD:275380
		leucine-rich repeat	216..239	CDD:275380
		LRR_8	239..298	CDD:290566
		leucine-rich repeat	240..263	CDD:275380
		leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..311	CDD:275380
		LRR_8	311..370	CDD:290566
		leucine-rich repeat	312..335	CDD:275380
		leucine-rich repeat	336..359	CDD:275380
		LRR_8	358..421	CDD:290566
		leucine-rich repeat	360..384	CDD:275380
		LRR_4	385..426	CDD:289563
		leucine-rich repeat	387..410	CDD:275380
		leucine-rich repeat	411..433	CDD:275380
		LRRCT	444..492	CDD:214507
		Ig	501..597	CDD:299845
		IG	503..597	CDD:214652
		I-set	601..691	CDD:254352	25/102 (25%)
		Ig_1	618..692	CDD:143240	19/85 (22%)
		I-set	695..782	CDD:254352	20/102 (20%)
		Ig	713..782	CDD:299845	16/84 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910