DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr1 and Kirrel2

DIOPT Version :9

Sequence 1:	NP_001286645.1	Gene:	dpr1 / 2768858	FlyBaseID:	FBgn0040726	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_766486.1	Gene:	Kirrel2 / 243911	MGIID:	2442334	Length:	700	Species:	Mus musculus

Alignment Length:	338	Identity:	71/338 - (21%)
Similarity:	115/338 - (34%)	Gaps:	67/338 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 PYFDFDVPRNLTVTVGQTGFLHCRVERLGDKD--VSWIR-------KRDLHILTAGGTTYTSDQR 108
            |:| ...|.::.|.:|:...|.|   .||...  |.|.:       :|||          ....|
Mouse    21 PHF-LQQPEDMVVLLGEEARLPC---ALGAYRGLVQWTKDGLALGGERDL----------PGWSR 71

  Fly   109 FQVLRPDGSANWTLQIKYPQPRDSGVYECQINTEPKMSLSYTFNVV---ELKAEIFGPSDLMVKT 170
            :.:.....|....|.||..:..|...||||.:.....|.....:|:   |....:.|||..:| .
Mouse    72 YWISGNSASGQHDLHIKPVELEDEASYECQASQAGLRSRPAQLHVMVPPEAPQVLGGPSVSLV-A 135

  Fly   171 GSDINLTCKIMQGPHELGNIFWYKGSEMLDGKGENEIDSSMARIRVEDDWTDGLTSRLKIKRAMP 235
            |...||||:..........:.|::....|||       ||..:..::|..|..:.:.|.:..:..
Mouse   136 GVPGNLTCRSRGDSRPAPELLWFRDGIRLDG-------SSFHQTTLKDKATGTVENTLFLTPSSH 193

  Fly   236 GDTGNYTC------VPT---VAKTSSVYV--HVIIGEHPAAMQHNSSSNSNSFYCGICCMLLSIV 289
            .|.....|      :||   .|.|.|:..  .|.:...|..:|...                .:.
Mouse   194 DDGATLICRARSQALPTGRDTAVTLSLQYPPMVTLSAEPQTVQEGE----------------KVT 242

  Fly   290 SCCLQHFYETGCGYLHAAAALAKSAGLGPPKRATLTTSETGIS---AAEVAAAAG-ASAAVASAL 350
            ..|.........||..|..........||  |..:....|.::   :.||:.|.| |:.:.|..:
Mouse   243 FLCQATAQPPVTGYRWAKGGSPVLGARGP--RLEVVADATFLTEPVSCEVSNAVGSANRSTALEV 305

  Fly   351 ATCNMLRERPAAI 363
            ....:|:.:|.::
Mouse   306 LYGPILQAKPKSV 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr1	NP_001286645.1	Ig	59..154	CDD:299845	23/103 (22%)
		IG_like	60..150	CDD:214653	23/98 (23%)
		IG_like	163..257	CDD:214653	24/104 (23%)
		Ig	174..244	CDD:143165	15/75 (20%)
Kirrel2	NP_766486.1	IG	27..116	CDD:214652	23/101 (23%)
		Ig	122..220	CDD:416386	24/105 (23%)
		Ig strand A	123..126	CDD:409353	0/2 (0%)
		Ig strand A'	129..133	CDD:409353	2/3 (67%)
		Ig strand B	140..147	CDD:409353	4/6 (67%)
		Cell attachment site. /evidence=ECO:0000255	146..148		0/1 (0%)
		Ig strand C	153..158	CDD:409353	0/4 (0%)
		Ig strand C'	161..163	CDD:409353	0/1 (0%)
		Ig strand D	166..173	CDD:409353	3/13 (23%)
		Ig strand E	180..188	CDD:409353	1/7 (14%)
		Ig strand F	197..205	CDD:409353	1/7 (14%)
		Ig strand G	211..217	CDD:409353	1/5 (20%)
		Ig_3	223..292	CDD:404760	13/86 (15%)
		Ig strand B	241..245	CDD:409353	0/3 (0%)
		Ig strand C	255..259	CDD:409353	2/3 (67%)
		Ig strand E	272..275	CDD:409353	1/2 (50%)
		Ig strand F	281..290	CDD:409353	0/8 (0%)
		Ig strand G	298..301	CDD:409353	0/2 (0%)
		Ig	315..392	CDD:416386	1/4 (25%)
		Ig strand A'	316..321	CDD:409353	0/3 (0%)
		Ig strand B	324..333	CDD:409353
		Ig strand C	339..343	CDD:409353
		Ig strand C'	346..348	CDD:409353
		Ig strand D	351..354	CDD:409353
		Ig strand E	355..360	CDD:409353
		Ig strand F	368..376	CDD:409353
		Ig strand G	382..392	CDD:409353
		Ig	394..498	CDD:416386
		Ig strand A	395..399	CDD:409353
		Ig strand A'	401..404	CDD:409353
		Ig strand B	412..419	CDD:409353
		Ig strand C	426..431	CDD:409353
		Ig strand C'	433..436	CDD:409353
		Ig strand D	444..451	CDD:409353
		Ig strand E	461..468	CDD:409353
		Ig strand F	479..486	CDD:409353
		Ig strand G	489..496	CDD:409353
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..576
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900