DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr1 and Cntn3

DIOPT Version :9

Sequence 1:	NP_001286645.1	Gene:	dpr1 / 2768858	FlyBaseID:	FBgn0040726	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_032805.2	Gene:	Cntn3 / 18488	MGIID:	99534	Length:	1028	Species:	Mus musculus

Alignment Length:	346	Identity:	76/346 - (21%)
Similarity:	112/346 - (32%)	Gaps:	118/346 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 PYFDFDVPRNLTVTVGQTGFLHCRVERLGDKDVSWIRKRDLHILTAGGTTYTSDQRFQVLRPDGS 117
            ||: ..:.|::.:.|..:.:..||..........|::..|..:|         ::|.|:
Mouse   318 PYW-LQLLRDVEIAVEDSLYWECRASGKPKPSYRWLKNGDALVL---------EERIQI------ 366

  Fly   118 ANWTLQIKYPQPRDSGVYECQINTEPKMSLSYTFNVVELKAEIFGP--------SDLMVKTGSDI 174
            .|..|.|......|||:::|  ..|.|..|.|  :..|||.....|        ..:.|:.||.:
Mouse   367 ENGALTITNLNVTDSGMFQC--IAENKHGLIY--SSAELKVVASAPDFSRNPMKKMVQVQVGSLV 427

  Fly   175 NLTCKIMQGPHELGNIFWYKGSEMLDGKGENEIDSSMARIRVEDDWTDGLTSRLKIKRAMPGDTG 239
            .|.||....|..|.  ||.||..|:         ...||:...:|      ..|||......|.|
Mouse   428 ILDCKPRASPRALS--FWKKGDMMV---------REQARVSFLND------GGLKIMNVTKADAG 475

  Fly   240 NYTCV------------------PTVAKTSSVYVHVIIGEH---PAAMQHN-------------- 269
            .|||.                  ||....:...:.|.:||.   |..:||:
Mouse   476 TYTCTAENQFGKANGTTHLVVTEPTRIILAPSNMDVAVGESVILPCQVQHDPLLDIMFAWYFNGA 540

  Fly   270 ----------------SSSNSNSFYCGICCMLLSIVSCCLQH------FYETGCGYLHAAAALAK 312
                            |||..           |.|.:..|:|      ..:||...:.:||.|..
Mouse   541 LTDFKKDGSHFEKVGGSSSGD-----------LMIRNIQLKHSGKYVCMVQTGVDSVSSAAELIV 594

  Fly   313 SAGLGPPKRA-----TLTTSE 328
            ....|||:..     |.||::
Mouse   595 RGSPGPPENVKVDEITDTTAQ 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr1	NP_001286645.1	Ig	59..154	CDD:299845	20/94 (21%)
		IG_like	60..150	CDD:214653	19/89 (21%)
		IG_like	163..257	CDD:214653	27/119 (23%)
		Ig	174..244	CDD:143165	20/69 (29%)
Cntn3	NP_032805.2	Ig	25..120	CDD:416386
		Ig strand A	27..31	CDD:409353
		Ig strand A'	34..39	CDD:409353
		Ig strand B	45..53	CDD:409353
		Ig strand C	58..64	CDD:409353
		Ig strand C'	66..69	CDD:409353
		Ig strand D	76..80	CDD:409353
		Ig strand E	82..88	CDD:409353
		Ig strand F	95..104	CDD:409353
		Ig strand G	107..120	CDD:409353
		Ig	129..214	CDD:416386
		Ig strand A	130..135	CDD:409353
		Ig strand B	139..145	CDD:409353
		Ig strand C	153..159	CDD:409353
		Ig strand C'	164..166	CDD:409353
		Ig strand D	171..176	CDD:409353
		Ig strand E	179..183	CDD:409353
		Ig strand F	193..201	CDD:409353
		Ig strand G	203..214	CDD:409353
		Ig	227..315	CDD:416386
		Ig strand A	227..232	CDD:409353
		Ig strand A'	235..240	CDD:409353
		Ig strand B	243..252	CDD:409353
		Ig strand C	258..262	CDD:409353
		Ig strand C'	265..267	CDD:409353
		Ig strand D	276..279	CDD:409353
		Ig strand E	280..285	CDD:409353
		Ig strand F	293..301	CDD:409353
		Ig strand G	304..315	CDD:409353
		Ig	320..403	CDD:416386	22/102 (22%)
		Ig strand A'	326..330	CDD:409353	0/3 (0%)
		Ig strand B	334..342	CDD:409353	2/7 (29%)
		Ig strand C	348..353	CDD:409353	1/4 (25%)
		Ig strand C'	355..358	CDD:409353	1/2 (50%)
		Ig strand D	363..367	CDD:409353	2/9 (22%)
		Ig strand E	369..374	CDD:409353	1/4 (25%)
		Ig strand F	383..390	CDD:409353	1/8 (13%)
		Ig strand G	394..403	CDD:409353	4/10 (40%)
		Ig	408..496	CDD:416386	25/104 (24%)
		Ig strand A	408..413	CDD:409353	1/4 (25%)
		Ig strand A'	416..421	CDD:409353	0/4 (0%)
		Ig strand B	425..432	CDD:409353	2/6 (33%)
		Ig strand C	440..444	CDD:409353	2/5 (40%)
		Ig strand D	458..461	CDD:409353	0/2 (0%)
		Ig strand E	462..467	CDD:409353	2/4 (50%)
		Ig strand F	475..483	CDD:409353	4/7 (57%)
		Ig strand G	489..496	CDD:409353	0/6 (0%)
		Ig	498..598	CDD:416386	20/110 (18%)
		Ig strand A	498..504	CDD:409353	2/5 (40%)
		Ig strand A'	507..512	CDD:409353	0/4 (0%)
		Ig strand B	515..523	CDD:409353	2/7 (29%)
		Ig strand C	532..536	CDD:409353	0/3 (0%)
		Ig strand E	560..564	CDD:409353	1/14 (7%)
		Ig strand F	573..580	CDD:409353	0/6 (0%)
		Ig strand G	587..591	CDD:409353	1/3 (33%)
		FN3	598..695	CDD:238020	6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	684..714
		FN3	703..795	CDD:238020
		FN3	805..898	CDD:238020
		FN3	906..991	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910