DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr1 and Papln

DIOPT Version :9

Sequence 1:	NP_001286645.1	Gene:	dpr1 / 2768858	FlyBaseID:	FBgn0040726	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_001192272.1	Gene:	Papln / 170721	MGIID:	2386139	Length:	1302	Species:	Mus musculus

Alignment Length:	298	Identity:	72/298 - (24%)
Similarity:	97/298 - (32%)	Gaps:	78/298 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 NAALAPTPPTTST-------TTISPSNLLP----YFDFDVPRNLTVTVGQTGFLHCRVERLGDKD 84
            |..|...||...|       ..:|||:..|    ..|...|..:..:.||...|.||.|......
Mouse  1032 NPDLGHGPPHRGTGAEAGGHRVLSPSHPRPATRLRLDRTQPGVVDASPGQRIRLTCRAEGFPVPT 1096

  Fly    85 VSWIRKRDLHILTAGGTTYTSDQRFQVLRPDGSANWTLQIKYPQPRDSGVYEC-QINTEPKMSLS 148
            :.|.|...|          .|..|.|| :||||    |.|......|.|.|.| ..|.:.:....
Mouse  1097 IEWQRDGQL----------VSSPRHQV-QPDGS----LVISRVDVEDGGYYSCVAFNGQDRDQRW 1146

  Fly   149 YTFNVVELKAEIFG-PSDLMVKTGSDINLTCKIMQGPHELGNIFWYKGSEMLDGKGENEIDSSMA 212
            ....|:. :..|.| |..:.|..|....|.| ::.|  |..||.|.:....:...|.
Mouse  1147 VQLRVLR-ELTITGLPPAVTVAEGDTARLLC-VVAG--ESVNIRWSRNGLPIQADGH-------- 1199

  Fly   213 RIRVEDDWTDGLTSRLKIKRAMPGDTGNYTC-----VPTVAKTSSVYVHVIIGEHPAAMQHNSSS 272
            |:....|.|      |.|....|.|.|:|||     ...|::::.|.|.:   ..|||...:...
Mouse  1200 RVHQSPDGT------LLIHNLRPRDEGSYTCSAFRGSQAVSRSTEVKVAL---PAPAAQSRDLGK 1255

  Fly   273 N-------------------SNSFYCGICCMLLSIVSC 291
            :                   .|.:|...||     .||
Mouse  1256 DCIDQPELANCALILQAQLCGNEYYSSFCC-----ASC 1288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr1	NP_001286645.1	Ig	59..154	CDD:299845	25/95 (26%)
		IG_like	60..150	CDD:214653	25/90 (28%)
		IG_like	163..257	CDD:214653	25/98 (26%)
		Ig	174..244	CDD:143165	19/74 (26%)
Papln	NP_001192272.1	TSP1	30..81	CDD:214559
		ADAM_spacer1	184..299	CDD:368694
		TSP1	309..362	CDD:214559
		TSP1	389..447	CDD:214559
		TSP1	447..504	CDD:214559
		TSP1	511..562	CDD:214559
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..648
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..737
		Kunitz_BPTI	771..822	CDD:333766
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..924
		Papilin_u7	831..922	CDD:374683
		Ig	932..>995	CDD:386229
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1024..1064		9/31 (29%)
		I-set	1070..1141	CDD:369462	25/85 (29%)
		Ig	1157..1241	CDD:386229	26/100 (26%)
		PLAC	1257..1289	CDD:370061	6/37 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900