DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr1 and dscam

DIOPT Version :9

Sequence 1:	NP_001286645.1	Gene:	dpr1 / 2768858	FlyBaseID:	FBgn0040726	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	XP_031751619.1	Gene:	dscam / 100216449	XenbaseID:	XB-GENE-921689	Length:	2039	Species:	Xenopus tropicalis

Alignment Length:	381	Identity:	77/381 - (20%)
Similarity:	127/381 - (33%)	Gaps:	128/381 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 PSNLLPYFDFDVPRNLTVTVGQTGFLHCRVERLGDKDVSWIRKRDL----HILTA---GGTTYTS 105
            |:::.|.      :|:|...|:..::||||.......:.|.:..:|    |...|   .||...|
Frog   504 PASIRPM------KNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLS 562

  Fly   106 DQRFQVLRPDGSANWTLQIKYPQPRDSGVYECQINTEPKMSLSYTFNVVELKAEIFGPSDLM-VK 169
            |.:..|                   |.|.|.|.:..:|::|.|.:.:|.........|.:.. ..
Frog   563 DVQKDV-------------------DEGEYMCNVLVQPQLSTSQSVHVTVKVPPFIQPFESQRFS 608

  Fly   170 TGSDINLTCKIMQGPHELGNIFWYKGSEMLDGKGENEIDSSMARIRVEDDWTDGLTSRLKIKRAM 234
            .|..:.:.|.::.|...: .|.|.|     ||:   .|.:|:.   |..|..| .||.|:|....
Frog   609 IGQRVFIPCVVVSGDLPI-TITWQK-----DGR---PIPASLG---VTIDNID-FTSSLRISNLS 660

  Fly   235 PGDTGNYTCVPTVAKTSSVYVHVIIGEHPAAMQHNSS-------------SNSNSFYCGICCMLL 286
            ....|||||   :|:..:           ||::|.|.             ::.:..|....
Frog   661 LMHNGNYTC---IARNDA-----------AAVEHQSQLIVRVPPRFVVQPTDQDGIYGKAV---- 707

  Fly   287 SIVSCCLQHFYETGCGYLHAAAALAKSAGLGPPK--------RATLTTS-----------ETGIS 332
             |::|..:       ||.........|.|.|.|:        |..|.|:           ::|..
Frog   708 -ILNCSAE-------GYPVPTIVWKYSKGAGVPQFQPIALNGRIQLLTNGSLLIKHVLEEDSGYY 764

  Fly   333 AAEVAAAAGASAAVA----------------SALAT--------CNMLRERPAAIR 364
            ..:|:...||..:.:                :.|||        |....|:|..:|
Frog   765 LCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVR 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr1	NP_001286645.1	Ig	59..154	CDD:299845	23/101 (23%)
		IG_like	60..150	CDD:214653	23/96 (24%)
		IG_like	163..257	CDD:214653	24/94 (26%)
		Ig	174..244	CDD:143165	20/69 (29%)
dscam	XP_031751619.1	Ig	26..121	CDD:416386
		Ig strand A'	33..37	CDD:409353
		Ig strand B	40..49	CDD:409353
		Ig strand C	55..61	CDD:409353
		Ig strand C'	63..66	CDD:409353
		Ig strand D	72..75	CDD:409353
		Ig strand E	80..85	CDD:409353
		Ig strand F	98..106	CDD:409353
		Ig strand G	109..121	CDD:409353
		Ig	124..217	CDD:416386
		Ig strand A'	127..136	CDD:409353
		Ig strand B	140..147	CDD:409353
		Ig strand C	157..162	CDD:409353
		Ig strand C'	164..167	CDD:409353
		Ig strand D	172..176	CDD:409353
		Ig strand E	179..185	CDD:409353
		Ig strand F	193..201	CDD:409353
		Ig strand G	205..217	CDD:409353
		Ig strand A	225..228	CDD:409353
		Ig strand A'	234..237	CDD:409353
		IG_like	236..310	CDD:214653
		Ig strand B	242..249	CDD:409353
		Ig strand C	255..260	CDD:409353
		Ig strand C'	262..264	CDD:409353
		Ig strand D	270..274	CDD:409353
		Ig strand E	276..280	CDD:409353
		Ig strand F	289..297	CDD:409353
		Ig strand G	300..310	CDD:409353
		Ig	313..395	CDD:416386
		Ig strand A	314..319	CDD:409353
		Ig strand A'	322..326	CDD:409353
		Ig strand B	329..339	CDD:409353
		Ig strand C	344..350	CDD:409353
		Ig strand C'	351..354	CDD:409353
		Ig strand E	368..374	CDD:409353
		Ig strand F	381..389	CDD:409353
		Ig	406..501	CDD:416386
		Ig strand A	406..409	CDD:409353
		Ig strand A'	415..419	CDD:409353
		Ig strand B	422..431	CDD:409353
		Ig strand C	436..442	CDD:409353
		Ig strand C'	444..447	CDD:409353
		Ig strand D	452..460	CDD:409353
		Ig strand E	464..473	CDD:409353
		Ig strand F	480..488	CDD:409353
		Ig strand G	491..501	CDD:409353
		Ig	504..593	CDD:416386	26/113 (23%)
		Ig strand A	505..507	CDD:409353	0/1 (0%)
		Ig strand A'	512..516	CDD:409353	2/3 (67%)
		Ig strand B	519..526	CDD:409353	1/6 (17%)
		Ig strand C	533..539	CDD:409353	1/5 (20%)
		Ig strand C'	540..542	CDD:409353	0/1 (0%)
		Ig strand D	549..553	CDD:409353	0/3 (0%)
		Ig strand E	557..563	CDD:409353	2/5 (40%)
		Ig strand F	571..579	CDD:409353	3/7 (43%)
		Ig strand G	583..593	CDD:409353	3/9 (33%)
		Ig	596..686	CDD:416386	28/116 (24%)
		Ig strand A	597..599	CDD:409353	0/1 (0%)
		Ig strand A'	604..608	CDD:409353	0/3 (0%)
		Ig strand B	611..620	CDD:409353	1/8 (13%)
		Ig strand C	625..632	CDD:409353	2/7 (29%)
		Ig strand C'	634..636	CDD:409353	1/4 (25%)
		Ig strand D	643..648	CDD:409353	2/4 (50%)
		Ig strand E	651..658	CDD:409353	4/6 (67%)
Ig strand F	665..673	CDD:409353	6/10 (60%)
Ig strand G	676..685	CDD:409353	4/8 (50%)
Ig_DSCAM	689..784	CDD:409397	16/106 (15%)
Ig strand B	707..711	CDD:409397	1/8 (13%)
Ig strand C	720..724	CDD:409397	0/3 (0%)
Ig strand E	749..753	CDD:409397	0/3 (0%)
Ig strand F	763..768	CDD:409397	0/4 (0%)
Ig strand G	777..780	CDD:409397	0/2 (0%)
Ig_DSCAM	785..885	CDD:409398	7/36 (19%)
Ig strand B	805..809	CDD:409398	0/3 (0%)
Ig strand C	818..822	CDD:409398	1/3 (33%)
Ig strand E	849..853	CDD:409398
Ig strand F	863..868	CDD:409398
Ig strand G	876..879	CDD:409398
FN3	886..980	CDD:238020
FN3	987..1084	CDD:238020
FN3	1093..1185	CDD:238020
FN3	1190..1279	CDD:238020
Ig_3	<1303..1364	CDD:404760
Ig strand B	1304..1311	CDD:409353
Ig strand C	1317..1322	CDD:409353
Ig strand C'	1327..1333	CDD:409353
Ig strand D	1337..1341	CDD:409353
Ig strand E	1343..1347	CDD:409353
Ig strand F	1356..1364	CDD:409353
Ig strand G	1367..1377	CDD:409353
FN3	1381..1471	CDD:238020
FN3	1497..1568	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910