DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mei-W68 and SPO11-2

DIOPT Version :9

Sequence 1:	NP_995901.1	Gene:	mei-W68 / 2768853	FlyBaseID:	FBgn0002716	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_176582.2	Gene:	SPO11-2 / 842702	AraportID:	AT1G63990	Length:	383	Species:	Arabidopsis thaliana

Alignment Length:	360	Identity:	98/360 - (27%)
Similarity:	164/360 - (45%)	Gaps:	35/360 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EFSENIERIALELLSNLVHGNATLS----VPRNSSGNVISE--------------YRRVSYNNRG 49
            |....||...|.||..|...:..:|    :.|..|.:.|::              :.:.|..|..
plant    28 EARARIEVSVLNLLRILNSPDPAISDLSLINRKRSNSCINKGILTDVSYIFLSTSFTKSSLTNAK 92

  Fly    50 SRHSFCVLIYMLSRVHRLQVRGGSFTVRGLYY----DNPLLVRSQSRIAEARLDVCRMLRTSPLS 110
            :..:|..:..::....::.::....|.|.|:|    |:|....||..:..:..||..:||.|..|
plant    93 TAKAFVRVWKVMEICFQILLQEKRVTQRELFYKLLCDSPDYFSSQIEVNRSVQDVVALLRCSRYS 157

  Fly   111 LGILAASKGLVAGDLRLLMTNGDVLDSSLYGGP-LTLPTDPEKIDR--IETLAEFVLIVEKESVF 172
            |||:|:|:|||||.|.|.....:.:|.|..|.. ..:..|...:|.  :.|.|.:::||||.::|
plant   158 LGIMASSRGLVAGRLFLQEPGKEAVDCSACGSSGFAITGDLNLLDNTIMRTDARYIIIVEKHAIF 222

  Fly   173 ESLLSRNVFGTFERRFILITGKGYPDCCTRRIVHRL-TEENQLAAYILVDADPFGVEIMLVYRHG 236
            ..|:...||....  .:.||.|||||..||..:||: |....|...:|||.:|.|:.|:..::.|
plant   223 HRLVEDRVFNHIP--CVFITAKGYPDIATRFFLHRMSTTFPDLPILVLVDWNPAGLAILCTFKFG 285

  Fly   237 SKSMSFSSQGLTTPALRWIGLHPSEIPAL-GTGAVALVAGDNKKINDLLARHDLEPGVRQELRML 300
            |..|...:..... .::||||...::..: ....|.|...|::....||:...|:....:||.::
plant   286 SIGMGLEAYRYAC-NVKWIGLRGDDLNLIPEESLVPLKPKDSQIAKSLLSSKILQENYIEELSLM 349

  Fly   301 QDVQLKAEIESV----IDFLTDDYIPNKINRNLFL 331
            .....:||||::    .::| ..||..||.:..::
plant   350 VQTGKRAEIEALYCHGYNYL-GKYIATKIVQGKYI 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-W68	NP_995901.1	Spo11	3..327	CDD:224611	98/354 (28%)
		TP6A_N	50..113	CDD:282286	16/66 (24%)
		TOPRIM_TopoIIB_SPO	161..315	CDD:173774	46/159 (29%)
SPO11-2	NP_176582.2	PLN00060	1..383	CDD:177691	98/358 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	119	1.000	Domainoid score	I1901
eggNOG	1	0.900	-	-		E1_COG1697
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	145	1.000	Inparanoid score	I1754
OMA	1	1.010	-	-		QHG56846
OrthoDB	1	1.010	-	-		D1272299at2759
OrthoFinder	1	1.000	-	-		FOG0002859
OrthoInspector	1	1.000	-	-		otm2591
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10848
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.940