DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mei-W68 and spo11

DIOPT Version :9

Sequence 1:	NP_995901.1	Gene:	mei-W68 / 2768853	FlyBaseID:	FBgn0002716	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	XP_031749912.1	Gene:	spo11 / 493562	XenbaseID:	XB-GENE-995590	Length:	396	Species:	Xenopus tropicalis

Alignment Length:	345	Identity:	113/345 - (32%)
Similarity:	183/345 - (53%)	Gaps:	32/345 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IERIALELLSNLVHGNATLSVPRNSS-----------GNVISEY---RRVSYNNRGSRHSFCVLI 58
            ||||...:..:|....|.:....|.:           |..|:::   |:|..|...|...|.:::
Frog    51 IERIIQGITESLSKNEAPVLTLDNRTNWANIEFNHLVGLQIAKHCTTRKVRSNCAKSAQKFALML 115

  Fly    59 YMLSRVHRLQVRGGSFTVRGLYYDNPLLVRSQSRIAEARLDVCRMLRTSPLSLGILAASKGLVAG 123
            .:||.:::|.......|.|.:||::..|..||:.:.....|:..||:...::|.||:.|||.|||
Frog   116 KVLSVIYKLVQTDTYTTKRDIYYNDVQLYGSQTVVDNIVSDLSCMLKIPRINLHILSTSKGCVAG 180

  Fly   124 DLRLLMTNGDVLDSSLY-GGP---LTLPTDPEKIDRIETLAEFVLIVEKESVFESLLSRNVFGTF 184
            ||.....:|    |.:| ||.   :.:|.:.|.|..:.|.|:|:||:||::.|:.||..| |...
Frog   181 DLWFTAEDG----SKVYCGGSSSGVLVPINVEGIRHLSTQAKFILIIEKDATFQRLLDDN-FCAR 240

  Fly   185 ERRFILITGKGYPDCCTRRIVHRLTEENQLAAYILVDADPFGVEIMLVYRHGSKSMSFSSQGLTT 249
            ....|||||||.||..||.:..:|.:...:..:.||||||:|:|||.:|::||.|||:.:..||.
Frog   241 SGPCILITGKGVPDLNTRLLTRKLWDSFHIPIFTLVDADPYGIEIMCIYKYGSISMSYEAHHLTV 305

  Fly   250 PALRWIGLHPSEIPAL---GTGAVALVAGDNKKINDLLARHDL--EPGVRQELRMLQDVQLKAEI 309
            ||:.|:||.||::..|   ....:.|...|.:|:..:..|..:  :|..::|:..:...:.||||
Frog   306 PAIAWLGLLPSDLERLFIPKDVLIPLSPLDRRKLLSIQKRPYIACQPLWKREIEKMAASERKAEI 370

  Fly   310 ESVI----DFLTDDYIPNKI 325
            :::.    |||:..|:|||:
Frog   371 QALTSLSPDFLSRVYLPNKL 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-W68	NP_995901.1	Spo11	3..327	CDD:224611	113/345 (33%)
		TP6A_N	50..113	CDD:282286	16/62 (26%)
		TOPRIM_TopoIIB_SPO	161..315	CDD:173774	58/162 (36%)
spo11	XP_031749912.1	PRK04342	45..396	CDD:235287	113/345 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5161
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	156	1.000	Inparanoid score	I4197
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1272299at2759
OrthoFinder	1	1.000	-	-		FOG0002859
OrthoInspector	1	1.000	-	-		oto103475
Panther	1	1.100	-	-	LDO	PTHR10848
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1077
SonicParanoid	1	1.000	-	-		X2691
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190