Protein Alignment mei-W68 and SPO11

DIOPT Version :10

• Sequence 1: NP_995901.1
• Gene: mei-W68 / 2768853
• FlyBaseID: FBgn0002716
• Length: 331
• Species: Drosophila melanogaster
• Sequence 2: XP_005260436.1
• Gene: SPO11 / 23626
• HGNCID: 11250
• Length: 407
• Species: Homo sapiens
• Alignment Length: 357
• Identity: 113/357 - (31%)
• Similarity: 190/357 - (53%)
• Gaps: 35/357 - (9%)

  Fly     3 EFSENIERIALELLSNLVHGNA-TLSVPRNSSGNVIS-------------EYRRVSYNNRGSRHS 53
            |...:||.|..:::::|....| ..::...||...|.             ..|::..::..|...
Human    46 EVLASIENIIQDIITSLARNEAPAFTIDNRSSWENIKFEDSVGLQMVSHCTTRKIKSDSPKSAQK 110

  Fly    54 FCVLIYMLSRVHRLQVRGGSFTVRGLYYDNPLLVRSQSRIAEARLDVCRMLRTSPLSLGILAASK 118
            |.:::.:||.:::|.......|.|.:||.:..|..:|:.:.....|:..||:.|..||.||:.||
Human   111 FSLILKILSMIYKLVQSNTYATKRDIYYTDSQLFGNQTVVDNIINDISCMLKVSRRSLHILSTSK 175

  Fly   119 GLVAGDLRLLMTNGDVLDSSLYGGPLTLPTDPEKIDRIETLAEFVLIVEKESVFESLLSRNVFGT 183
            ||:||:||.:..:|..::.:.....:.:|::.:.|..:.|.|:|||||||::.|:.||..| |..
Human   176 GLIAGNLRYIEEDGTKVNCTCGATAVAVPSNIQGIRNLVTDAKFVLIVEKDATFQRLLDDN-FCN 239

  Fly   184 FERRFILIT-----------GKGYPDCCTRRIVHRLTEENQLAAYILVDADPFGVEIMLVYRHGS 237
            .....|:||           |||.||..||.:|.:|.:...:..:.||||||.|:|||.:|::||
Human   240 KLSPCIMITSTPVFQHLKSKGKGVPDLNTRLLVKKLWDTFHVPVFTLVDADPHGIEIMCIYKYGS 304

  Fly   238 KSMSFSSQGLTTPALRWIGLHPSEIPALGT---GAVALVAGDNKKINDLLARH--DLEPGVRQEL 297
            .||||.:..||.||:||:||.||::..|..   ..:.|...|..|::.:|.|.  ..:|..|:|:
Human   305 MSMSFEAHHLTVPAIRWLGLLPSDLKRLNVPKDSLIPLTKRDQMKLDSILRRPYVTCQPFWRKEM 369

  Fly   298 RMLQDVQLKAEIESVI----DFLTDDYIPNKI 325
            .::.|.::||||:::.    |:|:..|:|||:
Human   370 EIMADSKMKAEIQALTFLSSDYLSRVYLPNKL 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mei-W68	NP_995901.1	Spo11	6..331	CDD:441303	112/354 (32%)
		TOPRIM_TopoIIB_SPO	161..315	CDD:173774	65/173 (38%)
SPO11	XP_005260436.1	SPO11_like	2..44	CDD:460961
		Spo11	46..407	CDD:441303	113/357 (32%)