DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mei-W68 and spo-11

DIOPT Version :9

Sequence 1:	NP_995901.1	Gene:	mei-W68 / 2768853	FlyBaseID:	FBgn0002716	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_502081.1	Gene:	spo-11 / 191771	WormBaseID:	WBGene00004985	Length:	425	Species:	Caenorhabditis elegans

Alignment Length:	281	Identity:	84/281 - (29%)
Similarity:	139/281 - (49%)	Gaps:	23/281 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 SRHSFCVL------------IYMLSRVHRLQVRGGSFTVRGLYYDNPLLVRSQSRIAEARLDVCR 102
            |:..||:.            ::.|.:|:.|.......|.|.|||::..:..:|..:..:...:|.
Worm    76 SKSHFCLRYTAKRKGKLDRDLHCLHQVYDLLENDKRSTKRELYYEHKAVYGNQKYLDSSIKSICE 140

  Fly   103 MLRTSPLSLGILAASKGLVAGDLRLLMTNGDVLDSSLYGGPLTLPTDPEKIDRIETLAEFVLIVE 167
            :|..|..:|.||:..:|::.|.:..|:.|..|:|:.:..   .|.||......|.:.|:|:|:||
Worm   141 LLNESRANLNILSCGRGIIRGAITFLVENVGVIDARVQE---VLITDALLFSNIISEADFILVVE 202

  Fly   168 KESVFESLLSRNVFGTFERRFILITGKGYPDCCTRRIVHRLTEENQLAAYILVDADPFGVEIMLV 232
            |::.|:.|:..|....|.|. ||.|.|||||..||.::..|:|:.:...|.|.||||.|:||.|.
Worm   203 KDTTFQKLMDENFQAMFPRG-ILATSKGYPDIATRNVLKMLSEKRKFPIYGLFDADPHGIEIYLT 266

  Fly   233 YRHGSKSMSFSSQGLTTPALRWIGLHPSEIPAL---GTGAVALVAGDNKKINDLLARHDLEPG-- 292
            |::|........:|...|.:.||||.|::....   .:..:.||..|..||..::.| .::.|
Worm   267 YKYGPTKEFAEGRGAFVPTIEWIGLFPTDFHRFTIDQSQCLPLVRTDFVKIEKMIPR-SIQLGEI 330

  Fly   293 -VRQELRMLQDVQLKAEIESV 312
             |.:||..:...:.|.|:||:
Worm   331 VVTRELDWMIQNKFKMELESI 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-W68	NP_995901.1	Spo11	3..327	CDD:224611	84/281 (30%)
		TP6A_N	50..113	CDD:282286	16/74 (22%)
		TOPRIM_TopoIIB_SPO	161..315	CDD:173774	55/158 (35%)
spo-11	NP_502081.1	TP6A_N	91..151	CDD:282286	13/59 (22%)
spo-11	NP_502081.1	TOPRIM_TopoIIB_SPO	196..358	CDD:173774	55/158 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164756
Domainoid	1	1.000	105	1.000	Domainoid score	I4191
eggNOG	1	0.900	-	-		E1_COG1697
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	126	1.000	Inparanoid score	I3272
Isobase	1	0.950	-	0	Normalized mean entropy	S3450
OMA	1	1.010	-	-		QHG56846
OrthoDB	1	1.010	-	-		D1272299at2759
OrthoFinder	1	1.000	-	-		FOG0002859
OrthoInspector	1	1.000	-	-		oto17790
orthoMCL	1	0.900	-	-		OOG6_101269
Panther	1	1.100	-	-	LDO	PTHR10848
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1077
SonicParanoid	1	1.000	-	-		X2691
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.750