Protein Alignment par-1 and BRSK2

DIOPT Version :9

• Sequence 1: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Sequence 2: XP_016874022.1
• Gene: BRSK2 / 9024
• HGNCID: 11405
• Length: 880
• Species: Homo sapiens
• Alignment Length: 962
• Identity: 252/962 - (26%)
• Similarity: 384/962 - (39%)
• Gaps: 246/962 - (25%)

  Fly   248 EHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNI 312
            :::|.|:|.||:|||....|||..|..|.::|||||:::.:|:...|.|:.||:.|:|:::||::
Human    14 QYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 78

  Fly   313 VKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLK 377
            :||..|.|.:|.|||::|:.||||:|||||..||:..||||..||||:||:.:||...|.|||||
Human    79 LKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLK 143

  Fly   378 AENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYT 442
            .||||||.:.||:|||||.::.....|.|:|.||||.||.||:.:|:||||.:.||||.||||:.
Human   144 PENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFA 208

  Fly   443 LVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMG 507
            |:.|:||||...||:|.|:|.||.:.:|.::..||::|||..:.::.|:|.:||.|....|...|
Human   209 LLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGG 273

  Fly   508 FEEDELKPYIEPKADL--------ADPKRIEALVAMGYNRSE---IEASLSQVRYDDVFATYLLL 561
            ..|.|.:..|..|..:        .||..::::.::|..|..   ::..||:....:....:|||
Human   274 KNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLL 338

  Fly   562 GRKSTDPESD-------------------------GSRSGSSLSLRNISGNDAGANAGSASVQSP 601
            .||...|..:                         |.|.....|:..:|..|.|:...:......
Human   339 DRKERYPSQEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTDGGSPVPARRAIEM 403

  Fly   602 THRGVHRSISASS----------TKPSR-RASSGVGPTNAAATVAAATGAVGAVNP--------- 646
            ...|..:::.:.|          :|..| |:.||       |:...:|..:.:..|
Human   404 AQHGQSKAMFSKSLDIAEAHPQFSKEDRSRSISG-------ASSGLSTSPLSSPRPIRKLVLPPP 461

  Fly   647 -------------SNNYNAAGSAAD-------RASVGSNFKRQNTIDSATIKENTARLAAQNQRP 691
                         |....|.|||:.       :|::..:.|.|.....|.:.:...:....|..|
Human   462 PPEPPFVARPLATSTEPEACGSASRPGHVLPLQAALRPDPKTQTLPCKAKLTDKPLQGTKSNPFP 526

  Fly   692 ASATQKMLTT----------ADTTLNSPAKPRTATKYDPTNGNRTVSGTSGIIPRRSTTLYEKTS 746
            ||...:...|          ....|..|.:|..|.....|....|:..|....||.|.....|.:
Human   527 ASTPARPPATGLCPQLAPPLGPPALRVPPRPPPAGIEPNTKSVPTIQVTPHPSPRGSPLPTPKGT 591

  Fly   747 STEKTNVIPAETNLFDRLRMASAVKSSRHFPRNVPSRSTFHSG-QTRARNNTALEYSGTSGASGD 810
            ........||.|                  |...|..|....| ..|||.|:.
Human   592 PVHTPKESPAGT------------------PNPTPPSSPSVGGVPWRARLNSI------------ 626

  Fly   811 SSHPGRMSFFSKLSSRFSKR----PTIADEA-----AKPRVLRFTWSMKTTSPLMPDQIMQKIRE 866
                 :.||..  |.||.:|    ||..:.:     :.|.:.:.:|.....|....:||...|::
Human   627 -----KNSFLG--SPRFHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFISLEKEEQIFVVIKD 684

  Fly   867 -----------------------VLDQNNCDYEQRERFVLWCVHGDPNT-DSLVQWEIEVC---- 903
                                   |:.|.:...|.:       ..|.|.. ...|::::::.
Human   685 KPLSSIKADIVHAFLSIPSLSHSVISQTSFRAEYK-------ATGGPAVFQKPVKFQVDITYTEG 742

  Fly   904 --KLPRLSLNGVRFKRISGTSIGFKNIASRIAFDLKLXLNQTNNEGNAAATASRPTDPTDTMTTT 966
              ......:..|.|..:||.|..||.:...|...|     .:.::..||...|         .||
Human   743 GEAQKENGIYSVTFTLLSGPSRRFKRVVETIQAQL-----LSTHDPPAAQHLS---------DTT 793

  Fly   967 NCRRPSNDSTSRLSELSLLCRSLTSQQGSQRRKKSRLSTGGSEDQKKSNSLLSAF-----QMYSP 1026
            ||...   .|.|||                                |..|.||.|     |:
Human   794 NCMEM---MTGRLS--------------------------------KCGSPLSNFFDVIKQL--- 820

  Fly  1027 FSSKENMQSSE------------EVEDLHVIDTQPGHSVDVPLFADFSPINP 1066
            ||.::|.|:::            .:.|.......||...:.|...|.:.:.|
Human   821 FSDEKNGQAAQAPSTPAKRSAHGPLGDSAAAGPGPGGDAEYPTGKDTAKMGP 872

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	125/251 (50%)
		S_TKc	253..504	CDD:214567	125/250 (50%)
		UBA_MARK_Par1	525..563	CDD:270522	9/40 (23%)
		MARK1-3_C	839..936	CDD:213381	20/126 (16%)
BRSK2	XP_016874022.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D302185at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920