DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment par-1 and HSL1

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_012821.2	Gene:	HSL1 / 853760	SGDID:	S000001584	Length:	1518	Species:	Saccharomyces cerevisiae

Alignment Length:	1236	Identity:	278/1236 - (22%)
Similarity:	469/1236 - (37%)	Gaps:	368/1236 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 VTSSNSATSNSTAATPTPASGAAATGGVGSVSQGPATVSASAANTNHSHQHSHQHHHHVANNMTT 171
            :|...|.||:.....|:..:..||...:..|:..|...|.              |...|..::..
Yeast     1 MTGHVSKTSHVPKGRPSSLAKKAAKRAMAKVNSNPKRASG--------------HLERVVQSVND 51

  Fly   172 DGARLSSNNSAVVASSAINHHHHHTPGSGVAPTVNKNVLSTHSAHPSAIKQRTSSAKGSPNMQMR 236
            ...|||..:|.|..:                                     |.|:|
Yeast    52 ATKRLSQPDSTVSVA-------------------------------------TKSSK-------- 71

  Fly   237 SSAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDK--------------- 286
                   |.:.:.:|.:||.||:|||:..:|:|||::.||:..||||:.|
Yeast    72 -------RKSRDTVGPWKLGKTLGKGSSGRVRLAKNMETGQLAAIKIVPKKKAFVHCSNNGTVPN 129

  Fly   287 ------------------------TQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYL 327
                                    :|.||..::   ||:.|||::.|.|::.||:|.|.:..|||
Yeast   130 SYSSSMVTSNVSSPSIASREHSNHSQTNPYGIE---REIVIMKLISHTNVMALFEVWENKSELYL 191

  Fly   328 IMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSE-LNIKI 391
            ::||..|||:|||||..|::.|:||...|:|||..|.|||...|.|||||.||||||.: ..|||
Yeast   192 VLEYVDGGELFDYLVSKGKLPEREAIHYFKQIVEGVSYCHSFNICHRDLKPENLLLDKKNRRIKI 256

  Fly   392 ADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLR 456
            ||||.:....|...|.|.||||.||:||:..|:.|.|...||||.|::|:.|::|.|||:...::
Yeast   257 ADFGMAALELPNKLLKTSCGSPHYASPEIVMGRPYHGGPSDVWSCGIVLFALLTGHLPFNDDNIK 321

  Fly   457 ELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETI--------------------MGD 501
            :|..:|..|||::|..:|::..:|:.|.||::|.||.:.:.|                    |..
Yeast   322 KLLLKVQSGKYQMPSNLSSEARDLISKILVIDPEKRITTQEILKHPLIKKYDDLPVNKVLRKMRK 386

  Fly   502 KWMNMGFEEDEL------KPYI---EPKADLADPKRIEALVAM--GYNRSEIEASLSQ--VRYDD 553
            ..|..|....:|      .|.|   ..|.:: |...:.:|..:  |.:|..|.|.|.|  :..:.
Yeast   387 DNMARGKSNSDLHLLNNVSPSIVTLHSKGEI-DESILRSLQILWHGVSRELITAKLLQKPMSEEK 450

  Fly   554 VFATYLLLGRK------STDPESDGSRSGSSLSLRNI-----SGNDAGANAGSASVQSPTHRGVH 607
            :|.:.||..::      |:..|:..|.:.||::...|     :.|:.|..:.:..|::.....:|
Yeast   451 LFYSLLLQYKQRHSISLSSSSENKKSATESSVNEPRIEYASKTANNTGLRSENNDVKTLHSLEIH 515

  Fly   608 RSISASSTKPSRRASSGVG-PTNAAATVAAATGAVGAVN-PSNN---------------YNAAGS 655
            .  ..:||.....|.:||. ..||......:..::..:: |.::               :||:.|
Yeast   516 S--EDTSTVNQNNAITGVNTEINAPVLAQKSQFSINTLSQPESDKAEAEAVTLPPAIPIFNASSS 578

  Fly   656 AADR---ASVGSNFKRQNTIDSATIKENTARLAAQNQRPASATQKMLTTADTTLNSPAKPRTATK 717
            ...|   .|:.|..:|       :::.:.:||:      .||:....|..|..:..|..|::.::
Yeast   579 RIFRNSYTSISSRSRR-------SLRLSNSRLS------LSASTSRETVHDNEMPLPQLPKSPSR 630

  Fly   718 YDPTNGNRTVSGTSGIIPRRSTTLYEKTSSTEKTNVIPAETNLFDRLRMASAVKSSRHFPRNVPS 782
            |.              :.||:......|.|..|:         ..|..:|:.|.:.|....:...
Yeast   631 YS--------------LSRRAIHASPSTKSIHKS---------LSRKNIAATVAARRTLQNSASK 672

  Fly   783 RSTF--HSGQTRARN-NTALEYSGTSGASGDSSHPGRMSFFSKLSSRFSKRPTIAD-EAAKPRVL 843
            ||.:  .|...|:.| |..|.:        |...|             ||:|...: ..::|.
Yeast   673 RSLYSLQSISKRSLNLNDLLVF--------DDPLP-------------SKKPASENVNKSEPH-- 714

  Fly   844 RFTWSMKTTS--PLMPDQI-----MQKIREVLDQNNCDYE-QRERFVLWCVHGD--PNTDSLVQW 898
                |:::.|  .::.|||     :.:|.|..:.|..:.: ||:|      ..|  .:.|:..
Yeast   715 ----SLESDSDFEILCDQILFGNALDRILEEEEDNEKERDTQRQR------QNDTKSSADTFT-- 767

  Fly   899 EIEVCKLPRLSLNGVRFKRISGTSIGFKNIASRIAFDLKLXLNQTN----NEGNAAATASRPTDP 959
                               |||.|...:|....  :..|: .||.|    ...|.:..:|.|...
Yeast   768 -------------------ISGVSTNKENEGPE--YPTKIEKNQFNMSYKPSENMSGLSSFPIFE 811

  Fly   960 TDTMTTTNCRRPSNDSTSRLSELSLLCRSLTSQQG---------SQRRKKS-------------- 1001
            .:...:::.........:.||:::.....:..|:|         .|.:||:
Yeast   812 KENTLSSSYLEEQKPKRAALSDITNSFNKMNKQEGMRIEKKIQREQLQKKNDRPSPLKPIQHQEL 876

  Fly  1002 RLSTGGSEDQKKSNSLLSAFQMYSPFSSKENMQSSEEVEDL------------------------ 1042
            |:::..::..|.|.||.....:..|.:||        ||.|
Yeast   877 RVNSLPNDQGKPSLSLDPRRNISQPVNSK--------VESLLQGLKFKKEPASHWTHERGSLFMS 933

  Fly  1043 -HVIDTQPGHSVDVPLFADFSPINPI--MEEDAEGVEGGKTSEAKVISGGSGQKVKGDGGGGGGG 1104
             ||.|.:|..:.||.:.:.:.|:..:  ...|...:....|.:..::|
Yeast   934 EHVEDEKPVKASDVSIESSYVPLTTVATSSRDPSVLAESSTIQKPMLS----------------- 981

  Fly  1105 NRLKRNIKHTGSLIVRKLTAGRHNDADKKGAIRKKDKEQQEVADTDKERPTSKPEGKVAMLRTTT 1169
              |..:..:| |:..:.|:....:|.|.| .:.....:.:.||   ...|..|...|:::...:.
Yeast   982 --LPSSFLNT-SMTFKNLSQILADDGDDK-HLSVPQNQSRSVA---MSHPLRKQSAKISLTPRSN 1039

  Fly  1170 L 1170
            |
Yeast  1040 L 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	117/311 (38%)
		S_TKc	253..504	CDD:214567	117/310 (38%)
		UBA_MARK_Par1	525..563	CDD:270522	11/41 (27%)
		MARK1-3_C	839..936	CDD:213381	19/106 (18%)
HSL1	NP_012821.2	STKc_BRSK1_2	79..369	CDD:270983	117/292 (40%)
HSL1	NP_012821.2	AMPKA_C_like	1347..1517	CDD:418410
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	255	1.000	Inparanoid score	I646
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960