Protein Alignment par-1 and GIN4

DIOPT Version :10

• Sequence 1: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Sequence 2: NP_010795.3
• Gene: GIN4 / 852119
• SGDID: S000002915
• Length: 1142
• Species: Saccharomyces cerevisiae
• Alignment Length: 1093
• Identity: 261/1093 - (23%)
• Similarity: 415/1093 - (37%)
• Gaps: 291/1093 - (26%)

  Fly   250 IGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQ---------------KLFR 299
            ||.:||.:|:|.|:..||:||::..||:|.|:|:|.|...|.|::.               .:.|
Yeast    16 IGPWKLGETLGLGSTGKVQLARNGSTGQEAAVKVISKAVFNTGNVSGTSIVGSTTPDALPYGIER 80

  Fly   300 EVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQ 364
            |:.|||:|:|||:::|:.|.||...|||::|||..||:|:.||..|.:.|.||...||||:..|.
Yeast    81 EIIIMKLLNHPNVLRLYDVWETNTDLYLVLEYAEKGELFNLLVERGPLPEHEAIRFFRQIIIGVS 145

  Fly   365 YCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGP 429
            |||...|:|||||.||||||.:.||||||||.:...|.|..|:|.||||.|||||:..|..|.|.
Yeast   146 YCHALGIVHRDLKPENLLLDHKYNIKIADFGMAALETEGKLLETSCGSPHYAAPEIVSGIPYQGF 210

  Fly   430 EVDVWSLGVILYTLVSGSLPFD--GSTLRELRERVLRGKYRIPF--YMSTDCENLLRKFLVLNPA 490
            ..||||.||||:.|::|.||||  ...:|.|..:|.:|::.:|.  .:|.:.::|:||.|.::|.
Yeast   211 ASDVWSCGVILFALLTGRLPFDEEDGNIRTLLLKVQKGEFEMPSDDEISREAQDLIRKILTVDPE 275

  Fly   491 KRASLETIMGDKWMNMGFEEDELKPYIEPKADLADPKRIEA-------LVAMGYNRSEIEASLSQ 548
            :|.....|:             ..|.::....:.|.|.|..       |..:..:.|.|:|::.|
Yeast   276 RRIKTRDIL-------------KHPLLQKYPSIRDSKSIRGLPREDTYLTPLSESNSSIDATILQ 327

  Fly   549 VRYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNISGNDAGANAGSA------SVQSPTHRGV- 606
                     .|::.....|||      |....||     :.||||...      ..:..|.:.:
Yeast   328 ---------NLVILWHGRDPE------GIKEKLR-----EPGANAEKTLYALLYRFKCDTQKELI 372

  Fly   607 -------HRSISASSTKPSRRAS----------SGVGPTNAAATVAAATGAVGAVNPSNNYNAAG 654
                   .:|||:.|..||::.|          |.:..|::.....:......:...|:|....|
Yeast   373 KQQQVKKRQSISSVSVSPSKKVSTTPQRRRNRESLISVTSSRKKPISFNKFTASSASSSNLTTPG 437

  Fly   655 SAADRASVGSNFKRQNTIDSATIKENTARLAAQNQRPASATQKMLTTADTTLNSPAKPRTATKYD 719
            |:...:...|:.|:.:||    :.:::...|::|:|.            :.:|.....:.|:.:.
Yeast   438 SSKRLSKNFSSKKKLSTI----VNQSSPTPASRNKRA------------SVINVEKNQKRASIFS 486

  Fly   720 PTNGNRTVSGT---SGIIP---RRSTT-----LYEKTSSTEKTNVIPAETNLFDRLRMASAVKSS 773
            .|..|:..|.:   ..:||   |.|.|     .|.|.:..:....|..||.           ::|
Yeast   487 TTKKNKRSSRSIKRMSLIPSMKRESVTTKLMSTYAKLAEDDDWEYIEKETK-----------RTS 540

  Fly   774 RHFPRNVPSRSTFHSGQTRARNNTALEYSGTSGASGDSSHPGRMSFFSKLSSRFSKRPTIADEAA 838
            .:|...:.....:...:...:....||               |....:|......:|....:|..
Yeast   541 SNFATLIDEIFEYEKYEQIRKEKEELE---------------RKVREAKAREELERRRRKQEEKE 590

  Fly   839 KPRVLRFTWSMKTTSPLMPDQIMQKIREVLDQNNCDYEQRERFVLWCVHGDPNTDSLVQWEIEVC 903
            :.|.|           |..:.:.:|..|:..|...|....|:                    |:.
Yeast   591 RARKL-----------LEKEDLKRKQEELKKQIEIDISDLEQ--------------------ELS 624

  Fly   904 KLPRLSLNG-VRF---------KRISGTSIGFKNIASRIAFDLKLXLNQTNNEGNAAATASRPTD 958
            |.....|:| :|.         |.|:...:...||..|..|.|:.......:.|...::.:....
Yeast   625 KHKEEKLDGNIRSISAPMENEEKNINHLEVDIDNILRRRNFSLQTRPVSRLDPGIMFSSPTEEVS 689

  Fly   959 PTDTMTTTN------------CRR---------------------PSNDSTSRLSELSLLCRSLT 990
            |.:...|.|            .||                     ||..:..||||..::..|..
Yeast   690 PVEPKRTENERLTTEKKILETIRRSKFLGSSFNIDKELKLSKMEYPSIIAPQRLSEERVVSDSND 754

  Fly   991 SQQ---------GSQRRKKSRLSTGGSEDQK--------------------KSNSLLSAFQMYSP 1026
            ..:         |..:.|.|..:|....|.:                    :||..||...|||.
Yeast   755 GYESLILPKDGNGVSQLKDSTATTAPVSDGRLRKISEIRVPQFTRKSRHFSESNKRLSVLSMYST 819

  Fly  1027 FSSKENMQSSEEVEDLHVIDTQPGHSVDVPLFAD-----FSPINPIMEEDAEGVEGGKTSEAKVI 1086
            ..|..|:....:..:|.| :.|....:..|..||     |..:|    |:||........|....
Yeast   820 KESFTNLVDILKNGNLDV-NNQQSQRIPTPRSADDSEFLFETVN----EEAEYTGNSSNDERLYD 879

  Fly  1087 SGGSGQKVK-------GDGGGG------------------GGGNRLKRNIKHTGSLIVRKLT--- 1123
            .|.|..|.|       .|...|                  .|.|.|::.....|.....|:.
Yeast   880 VGDSTIKDKSALKLNFADRFNGSNEAKQTDNLHLPILPPLNGDNELRKQNSQEGDQAHPKIKSMI 944

  Fly  1124 ----AGRHNDADKKGAIRKKDKEQQEVADTDKER----------PTSKPEGKV 1162
                :..|.:.:::...:::.|.:|...:.|:|:          |.:|...|:
Yeast   945 PESGSSSHTEKEEENEEKEEKKPEQHKQEEDQEKREKVVDDMEPPLNKSVQKI 997

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	117/270 (43%)
		UBA_MARK_Par1	525..563	CDD:270522	9/44 (20%)
		MARK1-3_C	839..936	CDD:213381	19/106 (18%)
GIN4	NP_010795.3	Protein Kinases, catalytic domain	17..289	CDD:473864	119/284 (42%)
		Kcc4p_like_C	1026..1139	CDD:213379