Protein Alignment par-1 and KIN2

DIOPT Version :9

• Sequence 1: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Sequence 2: NP_013197.1
• Gene: KIN2 / 850785
• SGDID: S000004086
• Length: 1147
• Species: Saccharomyces cerevisiae
• Alignment Length: 1151
• Identity: 270/1151 - (23%)
• Similarity: 438/1151 - (38%)
• Gaps: 290/1151 - (25%)

  Fly   217 PSAIKQRTSSAKGSPNMQMRSSAPMRWRATEEH-IGKYKLIKTIGKGNFAKVKLAKHLPTGKEVA 280
            |:.|||....|....|...|.:..:..|..... :|.::.::|:|.|:..||||.||..|.:...
Yeast    62 PADIKQGKEQAAQRQNDASRPNGAVELRQFHRRSLGDWEFLETVGAGSMGKVKLVKHRQTKEICV 126

  Fly   281 IKIIDK-------------TQLNPGSL--------------QKLFREVRIMKMLDHPNIVKLFQV 318
            |||:::             :..|...:              ::..||..:.::|.||:|.:||::
Yeast   127 IKIVNRASKAYLHKQHSLPSPKNESEILERQKRLEKEIARDKRTVREASLGQILYHPHICRLFEM 191

  Fly   319 IETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLL 383
            .......|::.||.|||::.||::.||.:||..||...|.|.||:||.|...|:|||||.||:::
Yeast   192 CTMSNHFYMLFEYVSGGQLLDYIIQHGSLKEHHARKFARGIASALQYLHANNIVHRDLKIENIMI 256

  Fly   384 DSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSL 448
            .|...|||.|||.||.|....:|.|||||..:|||||.:.:.|.|||||:||.|::||.||.|.:
Yeast   257 SSSGEIKIIDFGLSNIFDYRKQLHTFCGSLYFAAPELLKAQPYTGPEVDIWSFGIVLYVLVCGKV 321

  Fly   449 PFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDEL 513
            |||......|.|::.:||...|.::|.:..:||.:.:|::|.:||:|:.::...|||.|:  |..
Yeast   322 PFDDENSSILHEKIKKGKVDYPSHLSIEVISLLTRMIVVDPLRRATLKNVVEHPWMNRGY--DFK 384

  Fly   514 KPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFAT------------YLLLGRKST 566
            .|...|......|:.|::.|.....|.|.        .||:..|            |:.|.::..
Yeast   385 APSYVPNRVPLTPEMIDSQVLKEMYRLEF--------IDDIEDTRRSLIRLVTEKEYIQLSQEYW 441

  Fly   567 DPESDGSRSGSSLS------------LRN-ISGN--DAGANAGSASVQSPT---------HRGVH 607
            |..|:.....|||:            ::| |:.|  .:|.|...::.:.||         :..|.
Yeast   442 DKLSNAKGLSSSLNNNYLNSTAQQTLIQNHITSNPSQSGYNEPDSNFEDPTLAYHPLLSIYHLVS 506

  Fly   608 RSISASSTKPSRRASSGVGPTNAAATVAAATG-------AVGAVNPSNNYNAAGSAADRASVGSN 665
            ..::....|..||        .|.|..|.|..       |:|.....||
Yeast   507 EMVARKLAKLQRR--------QALALQAQAQQRQQQQQVALGTKVALNN---------------- 547

  Fly   666 FKRQNTIDSATIKENTARLAAQN----QRPASATQKMLTTADTTLNSPAKPRTATKYDPTNGNRT 726
                |:.|..|...:..:....|    |.||..|.   .|::.| |:..||.......|   ..|
Yeast   548 ----NSPDIMTKMRSPQKEVVPNPGIFQVPAIGTS---GTSNNT-NTSNKPPLHVMVPP---KLT 601

  Fly   727 VSGTSGIIP--RRSTTLYEKTSSTEKTNVIPAETNLFDRLRMASAVKSSRHFPRNVPSRSTFHSG 789
            :...:...|  |:|:.::.:.:...|:..:|.....  :.|.||.|                 .|
Yeast   602 IPEQAHTSPTSRKSSDIHTELNGVLKSTPVPVSGEY--QQRSASPV-----------------VG 647

  Fly   790 QTRARNNTALEYSGTSGASGDSSHPGRM----------SFFSKLSSRFSKRP-----TIAD---- 835
            :.:.:|.....:...| .||.|.||.|.          ::.||.:....|.|     ||:|
Yeast   648 EHQEKNTIGGIFRRIS-QSGQSQHPTRQQEPLPEREPPTYMSKSNEISIKVPKSHSRTISDYIPS 711

  Fly   836 ----------------EAAK-----PRVLRFTWSMKTTSPLMP---DQIMQKIREVLDQNNCDYE 876
                            :.||     |.:...:....:..|.:|   :.|:||.|:.|.|.|.|..
Yeast   712 ARRYPSYVPNSVDVKQKPAKNTTIAPPIRSVSQKQNSDLPALPQNAELIVQKQRQKLLQENLDKL 776

  Fly   877 Q-------RERFVLWCVHGDPNTDSLVQWEIEVCKLPRL-------SLNGVRFKRISGT------ 921
            |       ....|:..::.| |:|..    :.|.|..:|       |:...|.:.:..|
Yeast   777 QINDNDNNNVNAVVDGINND-NSDHY----LSVPKGRKLHPSARAKSVGHARRESLKFTRPPIPA 836

  Fly   922 SIGFKNIASRIAFDLKLXLNQTNNEGNAAATASRPTDPTDTMTTTNCRRPSNDSTSRLSELSLLC 986
            ::...::.:...|     |.:.|.|.....:::..|.|.|:.|.      |||:.:||:  |:..
Yeast   837 ALPPSDMTNDNGF-----LGEANKERYNPVSSNFSTVPEDSTTY------SNDTNNRLT--SVYS 888

  Fly   987 RSLTSQQGSQRRKKSRLSTGGSEDQKKSNSLLSAFQMYSPFS--------------SKENMQSSE 1037
            :.||.:|..:...|:...:..|.|..||..|...|.:.:..|              ::.|:...|
Yeast   889 QELTEKQILEEASKAPPGSMPSIDYPKSMFLKGFFSVQTTSSKPLPIVRHNIISVLTRMNIDFKE 953

  Fly  1038 EVEDLHVIDTQPGHSVDVPLFADFSPINPIMEEDAEGVEGGKTSE--------------AKVISG 1088
            .......:..:|  |::....       |::.....|::.||..:              :...|.
Yeast   954 VKGGFICVQQRP--SIETAAV-------PVITTTGVGLDSGKAMDLQNSLDSQLSSSYHSTASSA 1009

  Fly  1089 GSGQKVKGDGGGGGGGNR-----LKRNIKHTGSLIVRKLTAGRHNDADKKGAIRKKD----KEQQ 1144
            .....:|..|....|.|.     |..|.....|.|......|..::. ..|.:....    ::|.
Yeast  1010 SRNSSIKRQGSYKRGQNNIPLTPLATNTHQRNSSIPMSPNYGNQSNG-TSGELSSMSLDYVQQQD 1073

  Fly  1145 EVADTD--------------------KERPTSKPEGKVAMLRTTTL 1170
            ::..|.                    ||||..|.|..:..:|...|
Yeast  1074 DILTTSRAQNINNVNGQTEQTNTSGIKERPPIKFEIHIVKVRIVGL 1119

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	102/278 (37%)
		S_TKc	253..504	CDD:214567	102/277 (37%)
		UBA_MARK_Par1	525..563	CDD:270522	10/49 (20%)
		MARK1-3_C	839..936	CDD:213381	24/124 (19%)
KIN2	NP_013197.1	STKc_Kin1_2	97..377	CDD:270979	103/279 (37%)
		KA1	1104..1147	CDD:396635	4/16 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	255	1.000	Inparanoid score	I646
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5061
SonicParanoid	1	1.000	-	-		X401
TreeFam	0	0.000	Not matched by this tool.
	3	3.080