DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment par-1 and BRSK1

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_115806.1	Gene:	BRSK1 / 84446	HGNCID:	18994	Length:	778	Species:	Homo sapiens

Alignment Length:	900	Identity:	258/900 - (28%)
Similarity:	382/900 - (42%)	Gaps:	241/900 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 TSSAK----GSPNMQMRSSAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKII 284
            :|.||    |||...:....|...:.. :::|.|:|.||:|||....|||..|..||::|||||:
Human     2 SSGAKEGGGGSPAYHLPHPHPHPPQHA-QYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIV 65

  Fly   285 DKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKE 349
            ::.:|:...|.|:.||:.|:|:::||:::||..|.|.:|.|||::|:.||||:|||||..||:..
Human    66 NREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTP 130

  Fly   350 KEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPP 414
            ||||..|||||||:.:||...|.|||||.||||||.:.||:|||||.::.....|.|:|.||||.
Human   131 KEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPH 195

  Fly   415 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCEN 479
            ||.||:.:|:||||...|:||.||||:.|:.|:||||...||:|.|:|.||.:.:|.::..||::
Human   196 YACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQS 260

  Fly   480 LLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEP-------------KADLADPKRIEA 531
            |||..:.:.|.||.|||.|....|...|..|.:  |.:||             ..:| ||..:|:
Human   261 LLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPD--PCLEPAPGRRVAMRSLPSNGEL-DPDVLES 322

  Fly   532 LVAMG--YNRSEIEASL-SQVRYDDVFATYLLLGRKSTDPESD---------------------- 571
            :.::|  .:|..:...| |:....:....||||.||...|..:
Human   323 MASLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPML 387

  Fly   572 ---GSRSGSSLSLRNISGNDAGANAGSASVQSPTHRGVHRSISASSTKPSRRASSGVGPTNAAAT 633
               |.|.....|:..:|..|||  .|.:.|  ||.|.:..:      :.|:|:.|    .:.|:|
Human   388 SRHGKRRPERKSMEVLSITDAG--GGGSPV--PTRRALEMA------QHSQRSRS----VSGAST 438

  Fly   634 VAAATGAVGAVNPSNNYNAAGSAADRASVGSNFKRQNTIDSATIKENTARLAAQNQRPASATQKM 698
            ..:::......:|..:::....|.|.|..|.:                         |.|.||.:
Human   439 GLSSSPLSSPRSPVFSFSPEPGAGDEARGGGS-------------------------PTSKTQTL 478

  Fly   699 LTTADTTLNSPAKPRTATKYDPTNGNRTVSGTSGIIP----RRSTTLYEKTSSTEKTNVIPAETN 759
                                 |:.|.|  .|.:|..|    .|||.|.....|...:...|..:.
Human   479 ---------------------PSRGPR--GGGAGEQPPPPSARSTPLPGPPGSPRSSGGTPLHSP 520

  Fly   760 LFDRLRMASAVKSSRHFPRNVPSRSTFHSGQTRARNNTALEYSGTSGASGDSSHPG--------- 815
            |              |.||..|                    :||.|.:...| ||
Human   521 L--------------HTPRASP--------------------TGTPGTTPPPS-PGGGVGGAAWR 550

  Fly   816 ------RMSFFSKLSSRFSKR----PTIADE------AAKPRVLRFTWSMKTTSPLMPDQIMQKI 864
                  |.||..  |.||.:|    || |:|      .:.|.:.:.:|.....|....:||...:
Human   551 SRLNSIRNSFLG--SPRFHRRKMQVPT-AEEMSSLTPESSPELAKRSWFGNFISLDKEEQIFLVL 612

  Fly   865 RE-----------------------VLDQNNCDYEQRERFVLWCVHGDPNT-DSLVQWEIEVCK- 904
            ::                       ||.|.:...|.:       ..|.|:. ...|::::::..
Human   613 KDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYK-------ASGGPSVFQKPVRFQVDISSS 670

  Fly   905 -----LPRLSLNG------VRFKRISGTSIGFKNIASRIAFDLKLXLNQTN-----NEGNAAATA 953
                 .||...:|      |.|..|||.|..||.:...|...|....:|.:     :|.|.|.|
Human   671 EGPEPSPRRDGSGGGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTHDQPSVQALADEKNGAQT- 734

  Fly   954 SRPTDPTDTMTTTNCRRPSNDSTSRLSELSLLCRSLTSQQGSQRRKKSRLSTGGS 1008
             ||.............||..:.:|            :.::|..:.|| .|:|.|:
Human   735 -RPAGAPPRSLQPPPGRPDPELSS------------SPRRGPPKDKK-LLATNGT 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	128/251 (51%)
		S_TKc	253..504	CDD:214567	128/250 (51%)
		UBA_MARK_Par1	525..563	CDD:270522	11/40 (28%)
		MARK1-3_C	839..936	CDD:213381	24/132 (18%)
BRSK1	NP_115806.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		7/27 (26%)
		STKc_BRSK1_2	32..285	CDD:270983	129/252 (51%)
		UBA_BRSK	314..367	CDD:270525	15/53 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..548		50/282 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	719..778		16/71 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D302185at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920