DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment par-1 and TSSK1B

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_114417.1	Gene:	TSSK1B / 83942	HGNCID:	14968	Length:	367	Species:	Homo sapiens

Alignment Length:	282	Identity:	106/282 - (37%)
Similarity:	165/282 - (58%)	Gaps:	30/282 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 YKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQK-LFREVRIMKMLDHPNIVKLF 316
            |.|...:|:|::||||.|........|||||||:.:.....|:| |.||:.|:.||:|.:|:|.:
Human    12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTY 76

  Fly   317 QVIETEK-TLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAEN 380
            ::.||.. .:|::||.|..|::.:.:...|.:.|.|||.||.|:..|::|||...::|||||.:|
Human    77 EIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDN 141

  Fly   381 LLLDSELNIKIADFGFSNEFTPG-------SKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGV 438
            ||||.:.|||::||.||......       ||  ||||||.|||||:.||..|.....|:|||||
Human   142 LLLDKDFNIKLSDFSFSKRCLRDDSGRMALSK--TFCGSPAYAAPEVLQGIPYQPKVYDIWSLGV 204

  Fly   439 ILYTLVSGSLPFDGSTLRELRERVLRGKYRIPF----YMSTDCENLLRKFLVLNPAKRASLETIM 499
            |||.:|.||:|:|.|.::::..  ::.::|:.|    :::.:|::|:...|..:..:|..::.|:
Human   205 ILYIMVCGSMPYDDSNIKKMLR--IQKEHRVNFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEIL 267

  Fly   500 GDKWMNMGFEEDELKPYIEPKA 521
            ...||             :|||
Human   268 SHCWM-------------QPKA 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	101/263 (38%)
		S_TKc	253..504	CDD:214567	101/263 (38%)
		UBA_MARK_Par1	525..563	CDD:270522
		MARK1-3_C	839..936	CDD:213381
TSSK1B	NP_114417.1	STKc_TSSK1_2-like	10..272	CDD:271067	101/263 (38%)
TSSK1B	NP_114417.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	276..367		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910