DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment par-1 and Nuak1

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_001004363.1	Gene:	Nuak1 / 77976	MGIID:	1925226	Length:	658	Species:	Mus musculus

Alignment Length:	767	Identity:	212/767 - (27%)
Similarity:	328/767 - (42%)	Gaps:	176/767 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 DGARLSSNNSAVVASSAINHHHHHTPGSGVAPTVNKNVLSTHSAHPSAIKQRTSSAKGSPNMQMR 236
            :||.:|:........:.:       |||.:...............|..:|:.    ....|::.|
Mouse     2 EGAAVSAAGDGPAVETGL-------PGSPLEAVAGATAAPVEPRKPHGVKRH----HHKHNLKHR 55

  Fly   237 SSAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPG-SLQKLFRE 300
                            |:|.:|:|||.:.|||.|....:|:.||||.|.|.::... .:..:.||
Mouse    56 ----------------YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDELDMVHIRRE 104

  Fly   301 VRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQY 365
            :.||..|:||:|:.:::|.|.:..:.:||||||.||::||:....|:.|:|.|..||||||||.|
Mouse   105 IEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHY 169

  Fly   366 CHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPE 430
            ||:..::|||||.||:|||...||||||||.||.:.....|.||||||.||:||:..|:.|.|||
Mouse   170 CHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPE 234

  Fly   431 VDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASL 495
            ||.|:|||:||||:.|::||||...:.|..::..|:||.|...| |...|:|..|::||.:||::
Mouse   235 VDSWALGVLLYTLIYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDRRATI 298

  Fly   496 ETIMGDKWMNMGFEEDELKPYIEPKADLAD----PKRIEALVAM---GYNRS-----EIEASLSQ 548
            |.|....|:|.|:           |:.:.|    |.....|:|.   .::||     |.||.:..
Mouse   299 EDIANHWWVNWGY-----------KSSVCDCDALPDSESPLLARIIDWHHRSTGLQAEAEAKMKG 352

  Fly   549 VRYDDVFATYLLLGR----KSTDPESDGSRSGSSLSLRNISGNDAGANAGSASVQSPTHRGVHRS 609
            :....  |:.::|.|    |.:..|:|..:||..                              |
Mouse   353 LAKPG--ASEVVLERQRSLKKSKKENDFPQSGQD------------------------------S 385

  Fly   610 ISASSTKPSRRASSGVGPTNAAATVAA-ATGAV-GAVNPSNNYNAAGSAADRASVGSNFKRQNTI 672
            :..|.:|.|.:...|:....:.:...: :||.: |.|:|              ::.|.||.:..:
Mouse   386 VPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGIVSP--------------ALPSPFKMEQDL 436

  Fly   673 ----------------------DSAT------IKENTARLAAQNQRP-ASATQKMLTTADTT--- 705
                                  .|||      :|:...|.:.....| .|.:.::|.:.|..
Mouse   437 CRTAIPLPSSPEADMSGKLSLKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVVISG 501

  Fly   706 -LNSPAKPRTATKYDPTNGNRTVSGTSGIIPRRSTTLYEKTSSTEKTNVIPAETNLFDRLRMASA 769
             |:||..       ||..      |||..:..|...:.:.:|........||.|    |..|.:.
Mouse   502 GLSSPPP-------DPAR------GTSHSLSCRRKGILKHSSRYSDGGTDPALT----RPEMPTL 549

  Fly   770 VKSSRHFPRNVPSRSTFHSGQTRARNNTALEYSGTSGASGDS--------SHPGRMSFFSKLSS- 825
            ...|   |..|||     .|.:|:.:..:...|..|..|.||        :.|.|....|.:|:
Mouse   550 ESLS---PPGVPS-----DGISRSYSRPSSIISDDSVLSSDSFDLLELQENRPARQRIRSCVSAE 606

  Fly   826 RFSKRPTIADEAAKPRVLRFTWSMKTTSPLMPD-----QIMQKIREVLDQNN 872
            .|.:.........:||.........::..|:.|     |:.:|..|:..:.|
Mouse   607 NFLQLQDFETPHNRPRPQYLKRLADSSFSLLTDMDDVTQVYKKALEICSKLN 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	119/252 (47%)
		S_TKc	253..504	CDD:214567	119/251 (47%)
		UBA_MARK_Par1	525..563	CDD:270522	11/49 (22%)
		MARK1-3_C	839..936	CDD:213381	8/39 (21%)
Nuak1	NP_001004363.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		9/61 (15%)
		STKc_NUAK	54..307	CDD:270975	120/269 (45%)
		S_TKc	56..307	CDD:214567	119/251 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	353..422		16/100 (16%)
		GILK motif	400..403		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	441..568		31/151 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910