Protein Alignment par-1 and Nuak1

DIOPT Version :10

• Sequence 1: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Sequence 2: NP_001004363.1
• Gene: Nuak1 / 77976
• MGIID: 1925226
• Length: 658
• Species: Mus musculus
• Alignment Length: 767
• Identity: 212/767 - (27%)
• Similarity: 328/767 - (42%)
• Gaps: 176/767 - (22%)

  Fly   172 DGARLSSNNSAVVASSAINHHHHHTPGSGVAPTVNKNVLSTHSAHPSAIKQRTSSAKGSPNMQMR 236
            :||.:|:........:.:       |||.:...............|..:|:.    ....|::.|
Mouse     2 EGAAVSAAGDGPAVETGL-------PGSPLEAVAGATAAPVEPRKPHGVKRH----HHKHNLKHR 55

  Fly   237 SSAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPG-SLQKLFRE 300
                            |:|.:|:|||.:.|||.|....:|:.||||.|.|.::... .:..:.||
Mouse    56 ----------------YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDELDMVHIRRE 104

  Fly   301 VRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQY 365
            :.||..|:||:|:.:::|.|.:..:.:||||||.||::||:....|:.|:|.|..||||||||.|
Mouse   105 IEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHY 169

  Fly   366 CHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPE 430
            ||:..::|||||.||:|||...||||||||.||.:.....|.||||||.||:||:..|:.|.|||
Mouse   170 CHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPE 234

  Fly   431 VDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASL 495
            ||.|:|||:||||:.|::||||...:.|..::..|:||.|...| |...|:|..|::||.:||::
Mouse   235 VDSWALGVLLYTLIYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDRRATI 298

  Fly   496 ETIMGDKWMNMGFEEDELKPYIEPKADLAD----PKRIEALVAM---GYNRS-----EIEASLSQ 548
            |.|....|:|.|:           |:.:.|    |.....|:|.   .::||     |.||.:..
Mouse   299 EDIANHWWVNWGY-----------KSSVCDCDALPDSESPLLARIIDWHHRSTGLQAEAEAKMKG 352

  Fly   549 VRYDDVFATYLLLGR----KSTDPESDGSRSGSSLSLRNISGNDAGANAGSASVQSPTHRGVHRS 609
            :....  |:.::|.|    |.:..|:|..:||..                              |
Mouse   353 LAKPG--ASEVVLERQRSLKKSKKENDFPQSGQD------------------------------S 385

  Fly   610 ISASSTKPSRRASSGVGPTNAAATVAA-ATGAV-GAVNPSNNYNAAGSAADRASVGSNFKRQNTI 672
            :..|.:|.|.:...|:....:.:...: :||.: |.|:|              ::.|.||.:..:
Mouse   386 VPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGIVSP--------------ALPSPFKMEQDL 436

  Fly   673 ----------------------DSAT------IKENTARLAAQNQRP-ASATQKMLTTADTT--- 705
                                  .|||      :|:...|.:.....| .|.:.::|.:.|..
Mouse   437 CRTAIPLPSSPEADMSGKLSLKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVVISG 501

  Fly   706 -LNSPAKPRTATKYDPTNGNRTVSGTSGIIPRRSTTLYEKTSSTEKTNVIPAETNLFDRLRMASA 769
             |:||..       ||..      |||..:..|...:.:.:|........||.|    |..|.:.
Mouse   502 GLSSPPP-------DPAR------GTSHSLSCRRKGILKHSSRYSDGGTDPALT----RPEMPTL 549

  Fly   770 VKSSRHFPRNVPSRSTFHSGQTRARNNTALEYSGTSGASGDS--------SHPGRMSFFSKLSS- 825
            ...|   |..|||     .|.:|:.:..:...|..|..|.||        :.|.|....|.:|:
Mouse   550 ESLS---PPGVPS-----DGISRSYSRPSSIISDDSVLSSDSFDLLELQENRPARQRIRSCVSAE 606

  Fly   826 RFSKRPTIADEAAKPRVLRFTWSMKTTSPLMPD-----QIMQKIREVLDQNN 872
            .|.:.........:||.........::..|:.|     |:.:|..|:..:.|
Mouse   607 NFLQLQDFETPHNRPRPQYLKRLADSSFSLLTDMDDVTQVYKKALEICSKLN 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	119/252 (47%)
		UBA_MARK_Par1	525..563	CDD:270522	11/49 (22%)
		MARK1-3_C	839..936	CDD:213381	8/39 (21%)
Nuak1	NP_001004363.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..53		9/61 (15%)
		STKc_NUAK	54..307	CDD:270975	120/269 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	353..422		16/100 (16%)
		GILK motif	400..403		1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..568		31/151 (21%)