Protein Alignment par-1 and Brsk2

DIOPT Version :10

• Sequence 1: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Sequence 2: NP_001009930.1
• Gene: Brsk2 / 75770
• MGIID: 1923020
• Length: 719
• Species: Mus musculus
• Alignment Length: 607
• Identity: 196/607 - (32%)
• Similarity: 296/607 - (48%)
• Gaps: 89/607 - (14%)

  Fly   248 EHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNI 312
            :::|.|:|.||:|||....|||..|..|.::|||||:::.:|:...|.|:.||:.|:|:::||::
Mouse    15 QYVGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 79

  Fly   313 VKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLK 377
            :||..|.|.:|.|||::|:.||||:|||||..||:..||||..||||:||:.:||...|.|||||
Mouse    80 LKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLK 144

  Fly   378 AENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYT 442
            .||||||...||:|||||.::.....|.|:|.||||.||.||:.:|:||||.:.||||.||||:.
Mouse   145 PENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFA 209

  Fly   443 LVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMG 507
            |:.|:||||...||:|.|:|.||.:.:|.::..||::|||..:.::.|:|.:||.|....|...|
Mouse   210 LLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGG 274

  Fly   508 FEEDELKPYIEPKADL--------ADPKRIEALVAMGYNRSE---IEASLSQVRYDDVFATYLLL 561
            ..|.|.:..|..|..:        .||..::::.::|..|..   ::..||:....:....:|||
Mouse   275 KNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLL 339

  Fly   562 GRKSTDPESD-------------------------GSRSGSSLSLRNISGNDAGANA-GSASVQS 600
            .||...|..:                         |.|.....|:..:|..|.|:.. ...:::.
Mouse   340 DRKERYPSHEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTDGGSPVPARRAIEM 404

  Fly   601 PTHRGVHRSISASSTKPSRRASSGVGPTNAAATVAAATGAVGAVNPSNNYNAAGSAADRASVGSN 665
            ..|....||||.        ||||:                 :.:|.::.......:.|   ||.
Mouse   405 AQHGQRSRSISG--------ASSGL-----------------STSPLSSPRVTPHPSPR---GSP 441

  Fly   666 FKRQNTIDSATIKENTARLAAQNQRPASATQ--------KMLTTADTTLNSPAKPRTATKYDPTN 722
            ..........|.||:.|  ...|..|.|:..        ::.:..::.|.||...|...:..
Mouse   442 LPTPKGTPVHTPKESPA--GTPNPTPPSSPSVGGVPWRTRLNSIKNSFLGSPRFHRRKLQVP--- 501

  Fly   723 GNRTVSGTSGIIPRRSTTLYEKTSSTEKTNVIPAETNLFDRL--RMASAVKSS-RHFPRNVPSRS 784
               |....|.:.|..|..|.:|:......| :..|..:|..:  :..|::|:. .|...::||.|
Mouse   502 ---TPEEMSNLTPESSPELAKKSWFGNFIN-LEKEEQIFVVIKDKPLSSIKADIVHAFLSIPSLS 562

  Fly   785 TFHSGQTRARNNTALEYSGTSG 806
            .....||..|    .||..|.|
Mouse   563 HSVISQTSFR----AEYKATGG 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	125/251 (50%)
		UBA_MARK_Par1	525..563	CDD:270522	9/40 (23%)
		MARK1-3_C	839..936	CDD:213381
Brsk2	NP_001009930.1	STKc_BRSK1_2	18..271	CDD:270983	126/252 (50%)
		UBA_BRSK	298..351	CDD:270525	12/52 (23%)