DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment par-1 and Sik3

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_081774.3	Gene:	Sik3 / 70661	MGIID:	2446296	Length:	1369	Species:	Mus musculus

Alignment Length:	1033	Identity:	317/1033 - (30%)
Similarity:	456/1033 - (44%)	Gaps:	223/1033 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 GSGVAPTVNKNVLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAPMRWRATEEHIGKYKLIKTIGKG 262
            |:|.|....: :|...:|.|.|.......|.    :..|.:||....:....||.|::.:|||||
Mouse    16 GAGGAGPAGR-LLPPPAAGPPAAPAAVPPAA----VPARPTAPASRGSMAARIGYYEIDRTIGKG 75

  Fly   263 NFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYL 327
            |||.||.|.||.|..:||||||||:||:..:|:|:||||:|||||.||:|::|:||:|||:.:||
Mouse    76 NFAVVKRATHLVTKAKVAIKIIDKSQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYL 140

  Fly   328 IMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIA 392
            :.|||||||:||:||.||||.|||||.||:|||:||.:||.:.|:||||||||||||:.||||||
Mouse   141 VTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 205

  Fly   393 DFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRE 457
            ||||||.||||..|.|:||||||||||||:||:||||:||:|||||:||.||.|:||||||||:.
Mouse   206 DFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN 270

  Fly   458 LRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKAD 522
            ||.|||.||:||||:|||:||:|:|..|||:|.||.|:|.|...|||.:|..:......|.....
Mouse   271 LRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICRHKWMKLGDADPNFDRLIAECQQ 335

  Fly   523 L-----ADPKRIEALVA---MGYNRSEIEASLSQVRYDDVFATYLLL------------GRKSTD 567
            |     :||...:.|:|   ||.::.....||....||...|.|.||            |...:.
Mouse   336 LKEERQSDPLNDDVLLAMEDMGLDKERTLQSLRSDAYDHYSAIYSLLCDRHKKHKTLRPGALPSM 400

  Fly   568 PES---------DGSRSGSSLSL-----------RNISGNDAGANAGSASVQSPTHRGVHRSISA 612
            |::         ...::|::::|           ..|...|...|..|...:.|:...:.|.:|
Mouse   401 PQAMTFQAPVNLQAEQTGTAMNLSVPQVQLINPENQIIEPDGAVNLDSDEGEEPSPEALVRYLS- 464

  Fly   613 SSTKPSRRASSGVGP--TNAAATVAAATGAVGAVNPSN-------NYNAAGSAADRASVGS---- 664
                 .||.:.||..  |.....:.........|||..       |.|...:.....|:..
Mouse   465 -----MRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQGPFLQVAPNMNFTHNLLPMQSLQPTGQL 524

  Fly   665 NFKRQNTIDSATIK---------------ENTARLAAQN--QRPASATQKMLTTADTTLNSPAKP 712
            .:|.|:.:...|::               ....:|.||.  :||...:..:..|       ||.|
Mouse   525 EYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMT-------PAVP 582

  Fly   713 R-TATKYDPTNGNRTVSGTSGIIPRRST--TLYEKTSSTEKTNVIPAETNLFDRLRMASAVKSSR 774
            . |....:.::|..........:..||.  ||    :.|..|..||.:   ..|.....:.:|..
Mouse   583 AVTPVDEESSDGEPDQEAVQRYLANRSKRHTL----AMTSPTAEIPPD---LQRQLGQQSFRSRV 640

  Fly   775 HFPRNVPS--RSTFHSGQT----RARNNTALEYS-GTSGASGDSSHPGRMSFFSKLSSRFSKRPT 832
            ..|..||.  |||:....|    ..|.:....:| |.:......:|..:|...|.:.
Mouse   641 WPPHLVPDQHRSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNSSSIK-------- 697

  Fly   833 IADEAAKPRVLRFTWSMKTTSPLMPDQIMQKIREVLDQNNCDYEQRERFVLWCVHGDPNTDSLVQ 897
                       :.....:....:...|:.::..|...|.:..|:|.:.            ..::|
Mouse   698 -----------QLQQECEQLQKMYGGQVDERTLEKTQQQHMLYQQEQH------------HQILQ 739

  Fly   898 WEIE--VC-------------KLPRLSLNGVRFKRISGTSIGFKNIASRIAFDLKLXLNQTNNE- 946
            .:|:  :|             ..|.|..:.::..||..:|....:.::.:       ..|.:|.
Mouse   740 QQIQDSICPPQPSPPLQVACENQPALLTHQLQRLRIQPSSPPPNHPSNHL-------FRQPSNSP 797

  Fly   947 ---GNAAATASRPTDPTD-----------TMTTTNCRRPSNDSTSRLSELSLLCRSLTSQQGSQR 997
               .:|..|:...|.|:.           .....||..|.:        ::|.|..|  ||.||.
Mouse   798 PPVSSAMITSHGATSPSQFQGLPSHGAIFQQQPENCSPPPS--------VALTCLGL--QQASQS 852

  Fly   998 R-------------------------KKSRLSTGGSEDQKKSNSLLSAFQMYSPFS------SKE 1031
            :                         :...:|...|:.|.:..:.|.|     |||      ||:
Mouse   853 QPVTIQLQEPVDMLSNMAGTAAGSAGRSIPISPSASQIQIQHRASLMA-----PFSYGHRPLSKQ 912

  Fly  1032 NMQSSEEVEDLHVIDTQPGH----SVDVPLFADFSPINPIMEEDAEGVEGGKTSEAKV 1085
            ....|.|...|::....|.:    .:...||:|.|..:|.....:.||....|...||
Mouse   913 LSADSAEAHSLNMNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFPPTQALKV 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	173/251 (69%)
		S_TKc	253..504	CDD:214567	173/250 (69%)
		UBA_MARK_Par1	525..563	CDD:270522	14/52 (27%)
		MARK1-3_C	839..936	CDD:213381	13/111 (12%)
Sik3	NP_081774.3	STKc_SIK	65..317	CDD:270973	173/251 (69%)
		S_TKc	66..317	CDD:214567	173/250 (69%)
		UBA_SIK3	346..390	CDD:270593	12/43 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5061
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840