Protein Alignment par-1 and Smok3b

DIOPT Version :10

• Sequence 1: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Sequence 2: NP_001034978.1
• Gene: Smok3b / 622474
• MGIID: 3615348
• Length: 504
• Species: Mus musculus
• Alignment Length: 593
• Identity: 170/593 - (28%)
• Similarity: 272/593 - (45%)
• Gaps: 138/593 - (23%)

  Fly   234 QMRSSAPMRWRATEEHI-GKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKL 297
            ::||.:|:   |..:.: .:|.:::|||.|..|.||||:|..||..||:|.|.|.:.   ...::
Mouse    11 KLRSKSPL---ADMDGLHAQYVMLETIGHGGCATVKLAQHRLTGTHVAVKTIRKREY---WCNRV 69

  Fly   298 FREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSA 362
            ..||.::.|.|||||:.|.|||||:|.:|||||...|..::.::...|.::|.|||..|:|::||
Mouse    70 ISEVELLMMADHPNIISLLQVIETKKKVYLIMELCKGKSLYQHIRKAGYLQEHEARALFKQLLSA 134

  Fly   363 VQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYD 427
            :.|||.:.|:|||||.:|::::.:..:||.|||...:..||.||:.|||:.|::|||:.....||
Mouse   135 MNYCHNQGIVHRDLKPDNIMVEKDGKVKIIDFGLGTKVKPGQKLNLFCGTYPFSAPEVLLSTPYD 199

  Fly   428 GPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKR 492
            ||::|||:|||:||.:|:|.:|||..::::|.:|:|.|||.||..:|.:.::||...:..||..|
Mouse   200 GPKIDVWTLGVVLYFMVTGKIPFDACSIKKLVKRILAGKYSIPSRLSAELQDLLSLLMTANPKLR 264

  Fly   493 ASLETIMGDKWMNMGF--------EEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQV 549
            .::..:|...|:..|.        |:..|||         ||..::|:..:|:...:||.||.|.
Mouse   265 PTVAEVMVHPWVTEGSGVFPDPCEEQTPLKP---------DPAIVKAMGHIGFQAQDIEDSLRQR 320

  Fly   550 RYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNISGNDAGANAGSASVQSPTHRGVHRSISASS 614
            :::...|:|.|| :|....|.|
Mouse   321 KFNQTMASYCLL-KKQILKECD------------------------------------------- 341

  Fly   615 TKPSRRASSGVGPTNAAAT-----VAAATGAVGAVNPSNNYNAAGSAADRASVGSNFKRQNTIDS 674
             :|:|     ..|.|.:.|     |..||..:|.....|......|:|:|        :.:....
Mouse   342 -RPTR-----ARPVNPSVTPFPSLVDTATTRLGLRRRENEPTCPWSSANR--------QVSVCGK 392

  Fly   675 ATIKENTARLAAQN--QRPASATQKMLTTADTTLNSPAKPRTATKYDPTNGNRTVSGTSGIIPRR 737
            :|.|:...|::..:  .||......|..|...|.:.|..........|.:...:..|
Mouse   393 STSKKRDRRVSWPSVLGRPRHTAPTMDHTRTRTRSVPCICSMFCTVQPNSSEESTQG-------- 449

  Fly   738 STTLYEKTSSTEKTNVIPAETNLFDRLRMASAVKSSRHFPRN------------------VPSRS 784
                :.:.|:.:|    |..               ||.:||.                  :||:.
Mouse   450 ----HTRASAADK----PVH---------------SRGWPRGIKGWTRMIGNAMRKLCCCIPSKE 491

  Fly   785 TFHSGQTR 792
            |.|.||.|
Mouse   492 TSHLGQNR 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	106/251 (42%)
		UBA_MARK_Par1	525..563	CDD:270522	13/37 (35%)
		MARK1-3_C	839..936	CDD:213381
Smok3b	NP_001034978.1	STKc_AMPK-like	27..275	CDD:270905	106/250 (42%)
		UBA_MARK_Par1	295..334	CDD:270522	14/48 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..421		6/31 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..468		7/57 (12%)