DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment par-1 and sik2b

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	XP_696325.5	Gene:	sik2b / 567919	ZFINID:	ZDB-GENE-071012-1	Length:	896	Species:	Danio rerio

Alignment Length:	941	Identity:	290/941 - (30%)
Similarity:	409/941 - (43%)	Gaps:	239/941 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 QRTSSAKGSPNMQMRSSAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDK 286
            |:.::.:|          |:|       :|.|.:.:|:||||||.||||:|..|..|||||||||
Zfish     8 QKPAALRG----------PVR-------VGFYDIERTLGKGNFAVVKLARHRITKTEVAIKIIDK 55

  Fly   287 TQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKE 351
            |||:..:|:|::|||:||||||||:|:||:||:||:..|||:.|||..||:||||..|||:.|.|
Zfish    56 TQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKNMLYLVTEYAKNGEIFDYLAKHGRLSEPE 120

  Fly   352 ARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYA 416
            ||.||.||:|||:|||.:.|:||||||||||||..:|||||||||.|.|..|..|.|:|||||||
Zfish   121 ARRKFWQILSAVEYCHNRNIVHRDLKAENLLLDGHMNIKIADFGFGNFFQSGKPLATWCGSPPYA 185

  Fly   417 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLL 481
            |||:|:|::|:||::|:||:||:||.||.|:|||||.:|..||:|||.|::|||::|:.|||:|:
Zfish   186 APEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPSLPVLRQRVLEGRFRIPYFMTEDCEHLI 250

  Fly   482 RKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYI-----EPKADLAD--PKRIEALVAMGYNR 539
            |:.|||:|:||.|:..|...|||.|  |....:|.:     |.:|.:.:  .:.:..:.::|.::
Zfish   251 RRMLVLDPSKRLSIGQIKEHKWMVM--EVPVQRPMLYQQTTEGEAGVGEYNEQVLRLMHSLGIDQ 313

  Fly   540 SEIEASLSQVRYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNISGNDAGANAGSASVQSPTHR 604
            .:...||....|:...|.|.||..:                                   ...||
Zfish   314 HKTVESLQNKSYNHFAAIYYLLVER-----------------------------------LKAHR 343

  Fly   605 ---GVHRSISASSTKPSRRASSGVGPTNAAATVAAATGAVGAVNPSNNYNAAGSAADRASVGSNF 666
               .|...:.|...:||              |:|..|           ...|.|||.:.|
Zfish   344 CSFPVEPRLDARQRRPS--------------TIAEQT-----------LVKASSAAPQVS----- 378

  Fly   667 KRQNTIDSATIKENTARLAAQNQRPASATQKMLTTADTTLNSPAKPRTATKYDPTNGNRTVSGTS 731
                             |..||.|              .|..||.|:|             |..|
Zfish   379 -----------------LLPQNVR--------------LLRPPAVPQT-------------SADS 399

  Fly   732 GIIPRRSTTLYEKTSSTEKTNVIPAETNLFDRLRMASAVKSSRHFPRNVPSRS------------ 784
            ...|:.|..........|:.........:.|.|...:..|||...|.|:...|
Zfish   400 FTFPQSSCAAEHSLMEEEEVGTPKINGCMLDPLPPVAVRKSSASSPSNMMETSIDEGIETEEPDT 464

  Fly   785 ------TFHSGQTR---ARNNTALEYSG-----TSG----ASGDSSHPGRMSFFSKLSSRFSKRP 831
                  .|::.||.   .|.:|..|.:.     |||    :.|.:...|.:.....:.|..|...
Zfish   465 EDDHTHVFNAYQTARFGQRRHTLSEVTNQPGIITSGGKLFSMGHNPSLGSVDSEYDMGSMHSDLS 529

  Fly   832 TIAD-------EAAKPRVLRFTWSMKTTSPLMPDQIMQKI----REVLDQNNCDYEQRERFVLWC 885
            .:.|       ..|...|.|.|....:..|..|  .||.:    ||..:::...:.:..|
Zfish   530 LLEDGPSLNEVVLANTPVTRLTPPFISARPANP--TMQALSTQRRETHNRSPISFREGRR----- 587

  Fly   886 VHGDPN-TDSLVQWEIEVCKLPR----LSLNGVRFKRISG--TSIGFKNIASRIAFDLKLXLNQT 943
             ..|.: |..||.:...:..|.|    |.||.|..:..||  .|:|..:..:.....|.. |.:.
Zfish   588 -ASDTSLTQGLVAFRQHLQNLARTKGILELNKVYAQMGSGETPSLGLLSPQAHPHGLLDPALQEE 651

  Fly   944 NNEGNAAATASRPTDPTDTMTTTNCRRPSNDS---TSRLSELSLLC--------------RSLTS 991
            .......|..|..|.|     ....||.|.:.   ..|:.:.:|:.              |||..
Zfish   652 RGHQPDIALCSGGTHP-----ALLSRRQSLEPQYLPHRIQKATLMANSPSSCQMFCKETPRSLEQ 711

  Fly   992 QQGSQRRKKSRLSTGGSEDQKKSNSLLSAFQMY---SPFSSKENM---------QSSEEVEDLHV 1044
            |....|.::.||..     ||::.......||:   .||:....|         |....:...|
Zfish   712 QLQEHRLQQKRLYL-----QKQTQMQAYFNQMHIVEDPFAPCATMGHQDSGAPPQPQGSLAPAH- 770

  Fly  1045 IDTQPGHSVDVPLFADFSPINPIMEEDAEGV 1075
              .||..|   |.||...|:.|:||.:.|.:
Zfish   771 --QQPQSS---PPFAHAQPLGPLMEPNPEAL 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	157/251 (63%)
		S_TKc	253..504	CDD:214567	157/250 (63%)
		UBA_MARK_Par1	525..563	CDD:270522	8/39 (21%)
		MARK1-3_C	839..936	CDD:213381	24/107 (22%)
sik2b	XP_696325.5	STKc_SIK	21..273	CDD:270973	157/251 (63%)
		S_TKc	22..273	CDD:214567	157/250 (63%)
		UBA_SIK2	299..343	CDD:270592	8/78 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810