DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment par-1 and nuak2

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	XP_688764.3	Gene:	nuak2 / 560275	ZFINID:	ZDB-GENE-050208-563	Length:	576	Species:	Danio rerio

Alignment Length:	543	Identity:	179/543 - (32%)
Similarity:	263/543 - (48%)	Gaps:	108/543 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 GSPNMQMRSSAPMRWRATEEHIGK------YKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKT 287
            |:|      .||::.:|.:.|..|      |:.::|:|||.:.:||.|.. .:|..||||.|.|.
Zfish     5 GAP------EAPVKRQAVKRHHHKHNLKHRYEFLETLGKGTYGRVKKAMD-RSGTAVAIKSIRKE 62

  Fly   288 QL-NPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKE 351
            :: :...|..:.||:.||..|.||:|:.:::|.|.:..:.::||.||.|::|||:.....:.|.:
Zfish    63 KIRDEQELTHIRREIEIMSSLSHPHIISIYEVFENKDKIVIVMELASRGDLFDYICDSQPLAETQ 127

  Fly   352 ARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYA 416
            ||..||||||||.|||:..|:|||||.||:|||...||||||||.||.:.....|.|:||||.||
Zfish   128 ARHFFRQIVSAVHYCHRNGIVHRDLKLENILLDCNGNIKIADFGLSNLYRGDKLLQTYCGSPLYA 192

  Fly   417 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLL 481
            :||:..|:.|.|||||.|||||:||||:.|::||||...|.|.:::..|.||.|...|..| .|:
Zfish   193 SPEIVNGRPYRGPEVDSWSLGVLLYTLMHGAMPFDGHDHRILVQQISSGSYRKPSKPSDAC-GLI 256

  Fly   482 RKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASL 546
            |..|::||.:||:||.|.|..|:|.|||        .|....:||       |..:..||..|.:
Zfish   257 RWMLMVNPERRATLEDIAGHWWVNWGFE--------LPLLAQSDP-------ATAHPASEPAAVV 306

  Fly   547 SQVRYDDVFATYLLLGRKSTDPESDGS-------RSGSSL----SLR------NISGN------- 587
            ||.......|.:|   |:|:.|..:.|       |:|..:    |:|      |||.:
Zfish   307 SQTNGSTRIADWL---RRSSRPLLESSSKMRCLLRTGEPVQRQRSIRRSRKENNISQSMQETPRP 368

  Fly   588 -------------------------DAGANAGSASVQSPTHRGVHRSISASSTKPSRRASS--GV 625
                                     :..:||..|:|..|..:|:.:       |||...||  .:
Zfish   369 AKGILKKRGSLKLKAPPEPQLTPLEEKSSNALVAAVLPPPPKGILK-------KPSESESSCCSL 426

  Fly   626 GPTNAAATVAAATGAVGAVNPSNNYNAAGSAADRASVGSNFKRQNTIDSATIKENTARLAAQNQR 690
            .|.|:..|:.         |||...:..|.....:......:...::|...:   .:.......|
Zfish   427 SPQNSGQTLG---------NPSPVPHRKGILKRHSKFSGGLQEFGSLDQLAL---CSPAVVNRPR 479

  Fly   691 PASATQKMLTTADTTLNSPAKPR 713
            |:.|..:     |:.|:|.:..|
Zfish   480 PSGAVSE-----DSILSSESFDR 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	120/258 (47%)
		S_TKc	253..504	CDD:214567	119/251 (47%)
		UBA_MARK_Par1	525..563	CDD:270522	10/37 (27%)
		MARK1-3_C	839..936	CDD:213381
nuak2	XP_688764.3	STKc_NUAK2	25..279	CDD:271063	119/255 (47%)
nuak2	XP_688764.3	S_TKc	29..279	CDD:214567	119/251 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910