DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment par-1 and sik1

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_001119855.1	Gene:	sik1 / 553465	ZFINID:	ZDB-GENE-030131-9446	Length:	811	Species:	Danio rerio

Alignment Length:	710	Identity:	230/710 - (32%)
Similarity:	333/710 - (46%)	Gaps:	175/710 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 TSSAKGSPNMQMRSSAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTG-----------K 277
            |.|..|| :.....:.|::       :|.|::|:|:||||||.||||:|..|.           .
Zfish     5 TDSRTGS-HSSCAQARPLQ-------VGFYEIIRTLGKGNFAVVKLARHKVTKTQAITTFYFIFM 61

  Fly   278 EVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLV 342
            :|||||||||:||..:|:|::|||:|||:|:||:|:||:||:||:..||::.|||..||:||||.
Zfish    62 QVAIKIIDKTRLNSANLEKIYREVQIMKLLNHPHIIKLYQVMETKDMLYIVTEYAKNGEMFDYLT 126

  Fly   343 LHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLD 407
            .:|||.|.|||.||.||::||.|||:..|:|||||.||||||:.:|||:|||||.|.:..|..|.
Zfish   127 SNGRMSENEARKKFWQILTAVDYCHRHHIVHRDLKTENLLLDANMNIKLADFGFGNFYNAGEPLS 191

  Fly   408 TFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFY 472
            |:||||||||||:|:||:|:||::|:|||||:||.||.|||||||.:|..||:||..|::||||:
Zfish   192 TWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGDSLPALRQRVTEGRFRIPFF 256

  Fly   473 MSTDCENLLRKFLVLNPAKRASLETIMGDKWM-------------NMGFEEDELKPYIEPKADLA 524
            ||.|||||:||.||::||||.::..|...:||             ::......|..|.||...:
Zfish   257 MSQDCENLIRKMLVVDPAKRITIAQIKQHRWMLADPSAPHQTLSLSLTDYNSNLGDYSEPVLGI- 320

  Fly   525 DPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPES-----------DGSRSGSS 578
                   :..:|.:|.....||....|:...|.|.||..:..:..|           ..||:.|.
Zfish   321 -------MQTLGIDRQRTVESLQNSSYNHFSAIYYLLLERVKEHRSQQISRQCGAWNQRSRTASD 378

  Fly   579 LSLRNI--SGNDAGANAG---SASVQSPTHRGV------------------------HRSISASS 614
            .|...:  ..:|:..|:.   :..|.:|.|..:                        :||||.:|
Zfish   379 SSTPEVIMESSDSFRNSAFPVATKVNAPIHSEMECEQGGLFQRVVCPVEASLNGLLWNRSISPNS 443

  Fly   615 ---------TKP---------------------SRRASSGVGPTN-------AAATVAAATGAV- 641
                     .:|                     |||.:.....|:       ....|:.:.||.
Zfish   444 LLETTISEEVRPHDLEEEEGILQVQPPHLPSTTSRRHTLAEVSTSRFHQCSPPCIVVSPSDGASS 508

  Fly   642 -GAVNPSNNYN---------------------AAGSAADRASVGSNFKRQNTIDSATIKENTARL 684
             ..:..|:|.|                     |.|.|....::.||...||         ..:.|
Zfish   509 DSCLKSSSNTNPPLSPVVGDFSSLLISGTGPGALGPAGTPLALSSNLLLQN---------QGSML 564

  Fly   685 AAQNQRPASATQKMLTTADTTLNSPAKPRTATK---------------YDPTNGNRTVSGTSGII 734
            ||..|....|:...||..........:..|..|               ..|::.:|...|:.|..
Zfish   565 AASFQEGRRASDTSLTQGLKAFRQQLRKNTRAKGLLGLNKIKGLARQVCPPSSCSRGSRGSLGPT 629

  Fly   735 PRRSTTLYEKTSSTEKTNVIPAETNLFDRLRMASAVKS--------SRHFPRNVPSRSTF 786
            ....::|...:...|:.:::   ..:..:.||......        |:..|.:.||.:.|
Zfish   630 MCPPSSLQSSSGPRERRSML---EEVLHQQRMLQIQHQPQPQVQFLSQSHPSSPPSNNLF 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	154/262 (59%)
		S_TKc	253..504	CDD:214567	154/261 (59%)
		UBA_MARK_Par1	525..563	CDD:270522	9/37 (24%)
		MARK1-3_C	839..936	CDD:213381
sik1	NP_001119855.1	STKc_SIK	25..288	CDD:270973	154/262 (59%)
		S_TKc	26..288	CDD:214567	154/261 (59%)
		UBA_SIK1	309..358	CDD:270591	13/56 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810