DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment par-1 and melk

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_001016390.1	Gene:	melk / 549144	XenbaseID:	XB-GENE-987654	Length:	652	Species:	Xenopus tropicalis

Alignment Length:	725	Identity:	217/725 - (29%)
Similarity:	333/725 - (45%)	Gaps:	112/725 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 EEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPN 311
            ||.:..|:|.:|||.|.|||||||.||.||::|||||:||..|. ..|.::..|:..||.|.|.:
Frog     7 EELLKYYELHETIGTGGFAKVKLASHLTTGEKVAIKIMDKESLG-DDLPRVKTEIDAMKNLSHQH 70

  Fly   312 IVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDL 376
            :.:|:.||||...:::::||..|||:|||::...|:.|.||||.||||||||.|.|.:...||||
Frog    71 VCRLYHVIETPNKIFMVLEYCPGGELFDYIIAKDRLTEDEARVFFRQIVSAVAYIHSQGYAHRDL 135

  Fly   377 KAENLLLDSELNIKIADFGFSNEFTPGSKLD----TFCGSPPYAAPELFQGKKYDGPEVDVWSLG 437
            |.||||:|.:.|:|:.|||...:  |...||    |.||||.||||||.|||.|.|.|.|:||:|
Frog   136 KPENLLIDEDQNLKLIDFGLCAK--PKGGLDYHLMTCCGSPAYAAPELIQGKAYIGSEADIWSMG 198

  Fly   438 VILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDK 502
            |::|.|:.|.||||...:..|.::::||||.||.::|.....||.:.|.::|.||.|::.::...
Frog   199 VLMYALMCGYLPFDDDNVMVLYKKIMRGKYEIPKWLSPGSVLLLSQMLQVDPKKRISVKHLLSHP 263

  Fly   503 WMNMGFEEDELKPYIEPKADLADPKRIEALVAMGY---------------NRSEIEASLSQVRYD 552
            |:..|:               :.|...::...:||               :|:.....:|:..||
Frog   264 WLMQGY---------------SCPVEWQSKYPLGYVDEDCVTELSVFYKCSRTSTSRLISEWNYD 313

  Fly   553 DVFATYLLLGRKSTDPESDGSRSGSSLSLRNISGNDAGANAGSASVQSPTHRGVHRSISASSTKP 617
            .:.|:||||..|.:        .|..:.|:.      ....|...|.|      .:.:...||..
Frog   314 HITASYLLLHSKKS--------HGKPVRLKR------PLAVGDQPVTS------FKELRPKSTLD 358

  Fly   618 SRRASSGVGPTNAAATVAAATG--------------AVGAVNPSNNYNAAGSAADRASVGSNFKR 668
            ....:.|        .:|...|              |.....|.       :..:.....|.|..
Frog   359 FEEPNCG--------EIAYVFGSMEFSDDELFSEDFAYSCFEPH-------TPKEYVKGRSEFHS 408

  Fly   669 QNTIDSATIKENTARLAAQNQRPASATQKMLTTADTTLNSPAKPRTATKYDPTNGNRTVSGTSGI 733
            .::..|..:.:..||..::::....|.   |...:.....|| |.|.|.....|..:.:..|
Frog   409 VDSAPSTPVVQRYARHKSEDKENCDAA---LGKDENVFLHPA-PWTPTPRRKQNEKKGILTT--- 466

  Fly   734 IPRRSTTLYEKTSSTEKTNVIPAETNLFDRLRMASAVKSSRHFPRNVPSRSTFHSGQTRARNNTA 798
             |.:::...||..|.|.....|..|.    ..:|:.:...|.      .||. .....:|..::|
Frog   467 -PNKNSHTKEKNQSKETPTKKPITTG----EELANVISPERR------CRSV-ELDLNQAHVDSA 519

  Fly   799 LEYSGTSGASGDSSHPGRMSFFSKLSSRFSKRPTIADEAAKPRVLRFTWSMKTTSPLMPDQIMQK 863
            .:..|.....  |...|.....:.|:.  |||...|.|.  ||.||..:::.||:.:.|:|::.:
Frog   520 QKKKGAKVFG--SLERGLDKMITMLTP--SKRKGYAREG--PRKLRAHYNVTTTNIMNPEQLLNQ 578

  Fly   864 IREVLDQNNCDYEQRERFVLWCVHGDPNTDSLVQWEIEVCKLPRLSLNGVRFKRISGTSIGFKNI 928
            |.:||...|.||.|: .:.|.|..........:|:|:|||:|.:..:.|:|.:|:.|.:..:|.:
Frog   579 IVKVLPSKNVDYVQK-GYTLKCKTQSDFGKVTMQFELEVCQLSKSEMVGIRRQRLKGDAWVYKRL 642

  Fly   929 ASRIAFDLKL 938
            ...|....|:
Frog   643 VEDILSSCKV 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	122/255 (48%)
		S_TKc	253..504	CDD:214567	122/254 (48%)
		UBA_MARK_Par1	525..563	CDD:270522	12/52 (23%)
		MARK1-3_C	839..936	CDD:213381	29/96 (30%)
melk	NP_001016390.1	STKc_MELK	9..265	CDD:270980	122/258 (47%)
		UBA_MELK	284..334	CDD:270526	11/57 (19%)
		UBA-like. /evidence=ECO:0000250	284..323		8/38 (21%)
		Autoinhibitory region. /evidence=ECO:0000250	328..652		77/376 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..492		14/57 (25%)
		MELK_C	556..650	CDD:213383	28/94 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910