Protein Alignment par-1 and melk

DIOPT Version :10

• Sequence 1: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Sequence 2: NP_001016390.1
• Gene: melk / 549144
• XenbaseID: XB-GENE-987654
• Length: 652
• Species: Xenopus tropicalis
• Alignment Length: 725
• Identity: 217/725 - (29%)
• Similarity: 333/725 - (45%)
• Gaps: 112/725 - (15%)

  Fly   247 EEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPN 311
            ||.:..|:|.:|||.|.|||||||.||.||::|||||:||..|. ..|.::..|:..||.|.|.:
 Frog     7 EELLKYYELHETIGTGGFAKVKLASHLTTGEKVAIKIMDKESLG-DDLPRVKTEIDAMKNLSHQH 70

  Fly   312 IVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDL 376
            :.:|:.||||...:::::||..|||:|||::...|:.|.||||.||||||||.|.|.:...||||
 Frog    71 VCRLYHVIETPNKIFMVLEYCPGGELFDYIIAKDRLTEDEARVFFRQIVSAVAYIHSQGYAHRDL 135

  Fly   377 KAENLLLDSELNIKIADFGFSNEFTPGSKLD----TFCGSPPYAAPELFQGKKYDGPEVDVWSLG 437
            |.||||:|.:.|:|:.|||...:  |...||    |.||||.||||||.|||.|.|.|.|:||:|
 Frog   136 KPENLLIDEDQNLKLIDFGLCAK--PKGGLDYHLMTCCGSPAYAAPELIQGKAYIGSEADIWSMG 198

  Fly   438 VILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDK 502
            |::|.|:.|.||||...:..|.::::||||.||.::|.....||.:.|.::|.||.|::.::...
 Frog   199 VLMYALMCGYLPFDDDNVMVLYKKIMRGKYEIPKWLSPGSVLLLSQMLQVDPKKRISVKHLLSHP 263

  Fly   503 WMNMGFEEDELKPYIEPKADLADPKRIEALVAMGY---------------NRSEIEASLSQVRYD 552
            |:..|:               :.|...::...:||               :|:.....:|:..||
 Frog   264 WLMQGY---------------SCPVEWQSKYPLGYVDEDCVTELSVFYKCSRTSTSRLISEWNYD 313

  Fly   553 DVFATYLLLGRKSTDPESDGSRSGSSLSLRNISGNDAGANAGSASVQSPTHRGVHRSISASSTKP 617
            .:.|:||||..|.:        .|..:.|:.      ....|...|.|      .:.:...||..
 Frog   314 HITASYLLLHSKKS--------HGKPVRLKR------PLAVGDQPVTS------FKELRPKSTLD 358

  Fly   618 SRRASSGVGPTNAAATVAAATG--------------AVGAVNPSNNYNAAGSAADRASVGSNFKR 668
            ....:.|        .:|...|              |.....|.       :..:.....|.|..
 Frog   359 FEEPNCG--------EIAYVFGSMEFSDDELFSEDFAYSCFEPH-------TPKEYVKGRSEFHS 408

  Fly   669 QNTIDSATIKENTARLAAQNQRPASATQKMLTTADTTLNSPAKPRTATKYDPTNGNRTVSGTSGI 733
            .::..|..:.:..||..::::....|.   |...:.....|| |.|.|.....|..:.:..|
 Frog   409 VDSAPSTPVVQRYARHKSEDKENCDAA---LGKDENVFLHPA-PWTPTPRRKQNEKKGILTT--- 466

  Fly   734 IPRRSTTLYEKTSSTEKTNVIPAETNLFDRLRMASAVKSSRHFPRNVPSRSTFHSGQTRARNNTA 798
             |.:::...||..|.|.....|..|.    ..:|:.:...|.      .||. .....:|..::|
 Frog   467 -PNKNSHTKEKNQSKETPTKKPITTG----EELANVISPERR------CRSV-ELDLNQAHVDSA 519

  Fly   799 LEYSGTSGASGDSSHPGRMSFFSKLSSRFSKRPTIADEAAKPRVLRFTWSMKTTSPLMPDQIMQK 863
            .:..|.....  |...|.....:.|:.  |||...|.|.  ||.||..:::.||:.:.|:|::.:
 Frog   520 QKKKGAKVFG--SLERGLDKMITMLTP--SKRKGYAREG--PRKLRAHYNVTTTNIMNPEQLLNQ 578

  Fly   864 IREVLDQNNCDYEQRERFVLWCVHGDPNTDSLVQWEIEVCKLPRLSLNGVRFKRISGTSIGFKNI 928
            |.:||...|.||.|: .:.|.|..........:|:|:|||:|.:..:.|:|.:|:.|.:..:|.:
 Frog   579 IVKVLPSKNVDYVQK-GYTLKCKTQSDFGKVTMQFELEVCQLSKSEMVGIRRQRLKGDAWVYKRL 642

  Fly   929 ASRIAFDLKL 938
            ...|....|:
 Frog   643 VEDILSSCKV 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	122/255 (48%)
		UBA_MARK_Par1	525..563	CDD:270522	12/52 (23%)
		MARK1-3_C	839..936	CDD:213381	29/96 (30%)
melk	NP_001016390.1	STKc_MELK	9..265	CDD:270980	122/258 (47%)
		UBA_MELK	284..334	CDD:270526	11/57 (19%)
		UBA-like. /evidence=ECO:0000250	284..323		8/38 (21%)
		Autoinhibitory region. /evidence=ECO:0000250	328..652		77/376 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	443..492		14/57 (25%)
		MELK_C	556..650	CDD:213383	28/94 (30%)