Protein Alignment par-1 and Lkb1

DIOPT Version :10

• Sequence 1: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Sequence 2: NP_650302.1
• Gene: Lkb1 / 41673
• FlyBaseID: FBgn0038167
• Length: 567
• Species: Drosophila melanogaster
• Alignment Length: 614
• Identity: 160/614 - (26%)
• Similarity: 245/614 - (39%)
• Gaps: 147/614 - (23%)

  Fly   125 ASGAAATGGVGSVSQGPATVSASAANTNHSHQHSH-------QH--------------------- 161
            |:|.|..||.|:..|...|...:.....| |.|.|       ||
  Fly    13 AAGGAEAGGAGATGQMTVTTMEAQVKAAH-HHHLHHPTGGGAQHKVEEEEPDPVEDEMTVLLANK 76

  Fly   162 --HHHVANNMTTDGARLSSNNSAVVASSAINHHHHHTPGSGVAPTVNKNVLSTHSAHPSA----- 219
              |:.||::: .|.|.:........|..|         |:||.......:|.....||..
  Fly    77 NFHYDVASDL-DDDAFVELKEDTAQADDA---------GAGVGFYNPDELLLDDQPHPQVTWLDD 131

  Fly   220 ----IKQRTSSAKGSPNM-------------QMRSSAPMRWRATEEHIGKYKLIKTIGKGNFAKV 267
                ...|.:...|  ||             |.:.|..|        :|||.:...:|:|::.||
  Fly   132 DEIETLDRVTLDMG--NMFFNRVDSQDIIYQQKKKSIKM--------VGKYIMGDVLGEGSYGKV 186

  Fly   268 KLAKHLPTGKEVAIKIIDKTQLN--PGSLQKLFREVRIMKMLDHPNIVKLFQVI--ETEKTLYLI 328
            |.|.:......:|:||:.|.:|.  |...|.:.||:.::|.|.|.::|:|..|:  |.::.:||:
  Fly   187 KEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIALLKQLKHRHVVELVDVLYNEEKQKMYLV 251

  Fly   329 MEYASGG--EVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKI 391
            |||..||  |:.||.. ..||...:|...|:|:|..::|.|..|:||:|:|..||||..:..:||
  Fly   252 MEYCVGGLQEMIDYQP-DKRMPLFQAHGYFKQLVDGLEYLHSCRVIHKDIKPGNLLLSLDQTLKI 315

  Fly   392 ADFGFSNE---FTPGSKLDTFCGSPPYAAPELFQG-KKYDGPEVDVWSLGVILYTLVSGSLPFDG 452
            :|||.:.:   |.|.....|..|||.:..||:..| :.:.|.:||:||.||.||.|.:|..||:|
  Fly   316 SDFGVAEQLDLFAPDDTCTTGQGSPAFQPPEIANGHETFAGFKVDIWSSGVTLYNLATGQYPFEG 380

  Fly   453 STLRELRERVLRGKYRIP---FYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELK 514
            ..:..|.|.:.||::..|   :.|..|..||:...|..:|:||.||:.|..|.|    |....:|
  Fly   381 DNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQADPSKRLSLQEIRHDTW----FRSAPVK 441

  Fly   515 PYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRY----DDVFATYLLLGRKSTDPESDGSRS 575
                    ...|..|..|....|..|.:...|....|    :||:.|       ..|...:.:|.
  Fly   442 --------TGPPIPIPPLKGDKYRNSTVIPYLEAYHYGTQEEDVYFT-------EHDVNQELARQ 491

  Fly   576 GSSLSLRNISGNDAGANAGSASVQSPTHRGVHRSISASSTKPSRRASSGVGPTNAAATVAAATGA 640
            .::.:....:...|.|.|...:.:.|                             :.:.|||:.:
  Fly   492 AAAAASEIRAKQSAAALAACHTYEPP-----------------------------STSAAAASNS 527

  Fly   641 VGAVNPSNNYNAAGSAADRASVGSNFKRQ 669
            :|        |.:...|.....||..||:
  Fly   528 LG--------NGSREEAPVKKKGSALKRR 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	96/264 (36%)
		UBA_MARK_Par1	525..563	CDD:270522	10/41 (24%)
		MARK1-3_C	839..936	CDD:213381
Lkb1	NP_650302.1	STKc_LKB1	178..435	CDD:271021	95/261 (36%)