DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment par-1 and MARK3

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_001122390.2	Gene:	MARK3 / 4140	HGNCID:	6897	Length:	753	Species:	Homo sapiens

Alignment Length:	791	Identity:	432/791 - (54%)
Similarity:	530/791 - (67%)	Gaps:	100/791 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 PTVNKNVLSTHSAHPSA---IKQRTSSAKGSPNMQMRSSAPMRWRATEEHIGKYKLIKTIGKGNF 264
            ||||:.....|::|...   :..|||.:.......:.|.|.     .:.|||.|:|:||||||||
Human     8 PTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCAD-----EQPHIGNYRLLKTIGKGNF 67

  Fly   265 AKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIM 329
            ||||||:|:.||:||||||||||||||.|||||||||||||:|:||||||||:||||||||||||
Human    68 AKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIM 132

  Fly   330 EYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADF 394
            |||||||||||||.||||||||||.|||||||||||||||||:||||||||||||:::|||||||
Human   133 EYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADF 197

  Fly   395 GFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELR 459
            |||||||.|.||||||||||||||||||||||||||||||||||||||||||||||||..|:|||
Human   198 GFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELR 262

  Fly   460 ERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLA 524
            ||||||||||||||||||||||::||||||.||.:||.||.|:|:|.|.|||||||::||:.|::
Human   263 ERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDIS 327

  Fly   525 DPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNI-SGND 588
            |.|||:.:|.|||::.||:.|||:::||::.||||||||||::.::..|.|.|:|||..: ..:|
Human   328 DQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSD 392

  Fly   589 AGANAGSASVQSPTHRGVHRSISASSTKPSRRASSGVGPTNAAATVAAATGAVGAVNPSNNYNAA 653
            ...:.|    |||.|: |.||:  ||::..||.|...||  |..:|.|        .|..:..
Human   393 LNNSTG----QSPHHK-VQRSV--SSSQKQRRYSDHAGP--AIPSVVA--------YPKRSQT-- 438

  Fly   654 GSAADRASVGSNFKRQNTIDSATIKENTARLAAQNQRPASATQKMLTTADTTLNSPAKPRTATKY 718
             |.||     |:.| ::.|.|.  |.:.:.:..:...|||   .||..|.....:....|..:..
Human   439 -STAD-----SDLK-EDGISSR--KSSGSAVGGKGIAPAS---PMLGNASNPNKADIPERKKSST 491

  Fly   719 DPTNGNRTVSGTSGIIPRRSTTLYEKTSSTEKTNVI----------PAETNLFDRLRMASAVKSS 773
            .|::..     .||.:.||:|.:..:.::.::.:||          ...|.:.....::||....
Human   492 VPSSNT-----ASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPD 551

  Fly   774 R-HFPRNVPSRSTFHSGQTRARNNTALEYSGTSGASGDSSHP----------GRMSFFSKLSSRF 827
            | .|||...|||||| ||.|.|....  |:|.. ||...||.          |..:.||||:|:.
Human   552 RIRFPRGTASRSTFH-GQPRERRTAT--YNGPP-ASPSLSHEATPLSQTRSRGSTNLFSKLTSKL 612

  Fly   828 SKR----------PT--------------------IADEAAKPRVLRFTWSMKTTSPLMPDQIMQ 862
            ::|          ||                    ..::.||||.|||||||||||.:.|..:|:
Human   613 TRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMR 677

  Fly   863 KIREVLDQNNCDYEQRERFVLWCVHGDPNTDSLVQWEIEVCKLPRLSLNGVRFKRISGTSIGFKN 927
            :||:|||.|||||||||||:|:|||||.:.::|||||:|||||||||||||||||||||||.|||
Human   678 EIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKN 742

  Fly   928 IASRIAFDLKL 938
            |||:||.:|||
Human   743 IASKIANELKL 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	221/251 (88%)
		S_TKc	253..504	CDD:214567	221/250 (88%)
		UBA_MARK_Par1	525..563	CDD:270522	21/37 (57%)
		MARK1-3_C	839..936	CDD:213381	74/96 (77%)
MARK3	NP_001122390.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		9/27 (33%)
		STKc_MARK	55..307	CDD:270974	221/251 (88%)
		UBA_MARK3_4	325..367	CDD:270590	23/41 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..600		72/269 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	632..655		1/22 (5%)
		MARK1-3_C	654..751	CDD:213381	74/96 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	457	1.000	Domainoid score	I494
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55653
Inparanoid	1	1.050	737	1.000	Inparanoid score	I598
Isobase	1	0.950	-	0	Normalized mean entropy	S1552
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	1	1.000	-	-		otm41818
orthoMCL	1	0.900	-	-		OOG6_101232
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5061
SonicParanoid	1	1.000	-	-		X401
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.700