DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment par-1 and KP78a

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_650066.1	Gene:	KP78a / 41362	FlyBaseID:	FBgn0026064	Length:	705	Species:	Drosophila melanogaster

Alignment Length:	755	Identity:	314/755 - (41%)
Similarity:	416/755 - (55%)	Gaps:	141/755 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 GSVSQGPATVSASAANTNHSHQHSHQHHHHVANNMTTDGAR------LSSNNSAVVASSAINHHH 193
            |..|:..|..:|:..|...|         |....:.|.||.      .:||.:|:.|
  Fly    15 GKESEKTAMTAANKENDPDS---------HFTGTIVTTGATAQPATPTTSNATALPA-------- 62

  Fly   194 HHTP--------GSGVAPTVNKNVLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAPMRWRATEEHI 250
              ||        |.|...:.|     |.|...|.:       .|:.|
  Fly    63 --TPTVAAGQDLGDGACSSKN-----TDSKFQSYV-------NGNGN------------------ 95

  Fly   251 GKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKL 315
            |.||:|||:|||||||||||.|:|||:|||||:|||||||..:.|||:|||:|||:|:|||||:|
  Fly    96 GVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREVKIMKLLNHPNIVRL 160

  Fly   316 FQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAEN 380
            |||||:|:||||:|||||.||:||:||.:|||:|::|||.|||:|||:||||.|.::||||||||
  Fly   161 FQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYCHSKFVVHRDLKAEN 225

  Fly   381 LLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVS 445
            ||||..:|||||||||.|.|.|.::|:||||||||||||||.|:||.|||||.|||||:||||||
  Fly   226 LLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGRKYAGPEVDAWSLGVVLYTLVS 290

  Fly   446 GSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEE 510
            |||||||.||:||||||||||||:|:|:|.|||||:|||||||||||.||..:|.|||:|:|.:|
  Fly   291 GSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMRKFLVLNPAKRTSLSAVMSDKWINLGHDE 355

  Fly   511 -DELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLLG-------RKSTD 567
             |.|:|:.|...:|.|..|.:.|::||:.|.::|.|:....:||::.||:|||       .:||.
  Fly   356 SDRLRPFREKPMELQDAARFDLLMSMGHKRRDVEQSVKGQLFDDIYCTYMLLGVAKPRSSNRSTK 420

  Fly   568 PES----DGSRSGSSLSLRNISGNDAGANAGSASVQSPTHRGVHRSISASSTKPSRRAS------ 622
            ||:    |.:....|..|.||:              :||....|.:::.....|...:|
  Fly   421 PEAIPTVDLTTPAVSSPLPNIT--------------TPTVTIAHVTLALDKNPPIHSSSASGRPI 471

  Fly   623 -----------SGVGPTNAAATVAAATGAVGAVNPSNNYNAAGSAADRASVGSNFKRQNTIDSAT 676
                       :...||...|.....|.|......:.|:.:.....:.:|:...  .|:...||.
  Fly   472 APRLANAPNTPTSTPPTGPPAKPTRRTPARTPARKATNHTSGQGRPEPSSLPHT--PQSKRASAN 534

  Fly   677 IKENTARLAAQNQRPASATQKMLTTADTTLNSPAKPRTATKYDPTNGNRTVSGTSGIIPRRSTTL 741
            :......|:||.|  .:.|||:       .|:|  ||  .:|..........|:|    ||.|||
  Fly   535 MDVKPTLLSAQRQ--LAQTQKL-------ANTP--PR--FQYPVAQTPNQAQGSS----RRPTTL 582

  Fly   742 YEKTSSTEKTNVIPAE----TNLFDRLRMASAVK--SSRHFPRNVPSRSTFHSGQTRARNNTALE 800
            |||........::|..    ..|.:|:....||:  |.:.|.|...:|:|||.||.|:.......
  Fly   583 YEKAEPAVTPLLVPKSPAMGARLLERIPGGGAVEKTSDKPFTRQNVARATFHFGQARSGKRGGGS 647

  Fly   801 YSGTSG---------ASGDSSHP-GRMSFFSKLSSRFSKR 830
            .:|..|         .|.|.:.| .|:.|||||::||.:|
  Fly   648 GNGAGGEEDSYQTPPLSADDTKPASRVGFFSKLTARFGRR 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	190/251 (76%)
		S_TKc	253..504	CDD:214567	190/250 (76%)
		UBA_MARK_Par1	525..563	CDD:270522	15/44 (34%)
		MARK1-3_C	839..936	CDD:213381
KP78a	NP_650066.1	PKc_like	98..349	CDD:304357	190/250 (76%)
KP78a	NP_650066.1	S_TKc	98..349	CDD:214567	190/250 (76%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455438
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	273	1.000	Inparanoid score	I699
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24346
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.890