DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment par-1 and KP78b

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_001163587.1	Gene:	KP78b / 41361	FlyBaseID:	FBgn0026063	Length:	604	Species:	Drosophila melanogaster

Alignment Length:	696	Identity:	281/696 - (40%)
Similarity:	382/696 - (54%)	Gaps:	123/696 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 SAANTNHSHQHSHQHHHHVANNMTTDGARLSSNNSAVVASSAINHHHHHTPGSGVAPTVNKNVLS 211
            :||||                |.|||                    ..:.||...:       :|
  Fly     2 TAANT----------------NKTTD--------------------KENDPGPNTS-------IS 23

  Fly   212 THSAHPSAIKQRTSSAKGSPNMQMRSSAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTG 276
            |.:..|||..|......||..  .|||...:........|.||:|||:|||||||||||.|||||
  Fly    24 TTATPPSAAAQNVGGCFGSSG--GRSSPKFQSYVNGNGYGVYKIIKTLGKGNFAKVKLAIHLPTG 86

  Fly   277 KEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYL 341
            :|||||:||||.||..:.|||:|||.|||.|:|||||:|.||||:|:||||:|||.||||:|:||
  Fly    87 REVAIKLIDKTALNTIARQKLYREVNIMKKLNHPNIVRLLQVIESERTLYLVMEYVSGGELFNYL 151

  Fly   342 VLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKL 406
            |.:|||:|::|||.|||:|||::|||.|.|:||||||||||||.::.:||||||||..|.|.:.|
  Fly   152 VKNGRMRERDARVLFRQLVSAIEYCHSKSIVHRDLKAENLLLDQQMKLKIADFGFSTTFEPKAPL 216

  Fly   407 DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPF 471
            :||||||||||||||:||||.|||||.|||||:|||||||||||||:.|:|||:||||||||:|:
  Fly   217 ETFCGSPPYAAPELFRGKKYSGPEVDSWSLGVVLYTLVSGSLPFDGTNLKELRDRVLRGKYRVPY 281

  Fly   472 YMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEE-DELKPYIEPKADLADPKRIEALVAM 535
            |:|.:||:|:||||||||.:|.||..:|.|:|:|||:|: :.|:|:.|...||.|..|:..|..|
  Fly   282 YVSIECESLIRKFLVLNPTQRTSLSAVMADRWINMGYEQGNGLRPFQEKPMDLHDVNRLSLLSNM 346

  Fly   536 GYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNISGNDAGANAGSASVQS 600
            |:...::|.||...::||::.||:||  ....|.|......|..|.|.......|::.....:.:
  Fly   347 GHKPRDVEQSLKNQKFDDIYCTYMLL--DVAKPRSTACSEKSGSSFRETPTAMPGSSRIPVPIAA 409

  Fly   601 PTHRGVHRSISASSTKPSRRASSGVGPTNAAATVAAATGAVGAVNPSNNY---NAAGSAADRASV 662
            |.......:.:...:.|:|.|::.:.|  .|..:|.|...:....|...|   :|:.:|..|.|.
  Fly   410 PNVTISQVTFALDKSTPNRPAATSIRP--MAPRLANALTPLPLTPPPKKYICCSASKAANPRRSE 472

  Fly   663 GSNFKRQ--------NTIDSATIKENTARLAAQNQRPASATQKMLTTADTTLNSPAKPRTATKYD 719
            .|:..:.        :.:|..|...:..|..|.||:..||:.::   ......||::....|:..
  Fly   473 PSSIPQSAMPKKGVGSPVDVKTTLLSAQRKLAVNQKLTSASHQI---RSPITQSPSQASECTRTP 534

  Fly   720 PTNGNRTVSGTSGIIPRRSTTLYEKTSSTEKTNVIPAETNLFDRLRMASAVKSSRHFPRNVPSRS 784
            ||:                   :|...||...            |::...|.|:...|   ||
  Fly   535 PTH-------------------FEMLDSTSTP------------LKVLKLVASNSQTP---PS-- 563

  Fly   785 TFHSGQTRARNNTALEYSGTSGASGDSSHPGRMSFFSKLSSRFSKR 830
                                   :.:::.|.|:.||||||:||.:|
  Fly   564 -----------------------TENTNRPTRVGFFSKLSARFVRR 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	181/251 (72%)
		S_TKc	253..504	CDD:214567	181/250 (72%)
		UBA_MARK_Par1	525..563	CDD:270522	14/37 (38%)
		MARK1-3_C	839..936	CDD:213381
KP78b	NP_001163587.1	PKc_like	63..314	CDD:304357	181/250 (72%)
KP78b	NP_001163587.1	S_TKc	63..314	CDD:214567	181/250 (72%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455439
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24346
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840