DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment par-1 and sff

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_648814.3	Gene:	sff / 39732	FlyBaseID:	FBgn0036544	Length:	861	Species:	Drosophila melanogaster

Alignment Length:	976	Identity:	275/976 - (28%)
Similarity:	415/976 - (42%)	Gaps:	262/976 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 EHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNI 312
            :.:|.|:|.||:|||....|||..|...||:||||||::.:|:...|.|:.||:.|||::|||::
  Fly    13 QFVGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIAIMKLIDHPHV 77

  Fly   313 VKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLK 377
            :.|..|.|.:|.||||:|:.||||:|||||..||:..||||..||||:||:.:||...|.|||||
  Fly    78 LGLSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLK 142

  Fly   378 AENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYT 442
            .||||||.:.||||||||.::....||.|:|.||||.||.||:.:|:||||.:.||||.|||||.
  Fly   143 PENLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYA 207

  Fly   443 LVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMG 507
            |:.|:||||...||:|.|:|.||.:.||.::..||::|||..:.:||.:|.:|..|....|:..|
  Fly   208 LLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPWVTAG 272

  Fly   508 FE-EDELK-PYIE-------PKADLADPKRIEALVAMG-YNRSE--IEASLSQVRYDDVFATYLL 560
            .: |.||: |.:|       |.|...||..:.|:.::| :...|  |:..||.....:....:||
  Fly   273 GKGELELELPMMEVVQTHVIPTATAVDPDVLNAICSLGCFKEKEKLIQELLSSSHNTEKVIYFLL 337

  Fly   561 LGRKSTDP--ESDG-----SRS--------GSSLSLRNISGNDAGANAGSASVQSP--THRGVHR 608
            |.||...|  |.|.     |||        ...|....|:|.:| .:.|..|..||  ..|....
  Fly   338 LERKRRRPALEDDDEIAQKSRSELDAVDPPRKRLDTCRINGTNA-PSYGQISEGSPLTPRRQAFN 401

  Fly   609 SISASSTKPSRRASSGVGPTNAAATVAAATGAVGAVNPSNNYNAAGSAADRASVGSNFKRQNTID 673
            ..|.|||:..:|.|    ||...::|                                 |.::..
  Fly   402 FRSYSSTRNHQRRS----PTTVTSSV---------------------------------RSSSYH 429

  Fly   674 SATIKENTARLAAQNQRPASATQKMLTTADTTLNSPAKPRTATKYDPTNGNRTVSGTSGIIPRRS 738
            |.| :.|:...:||.|..|             ::.|:.|...|::. |.|:|..||....:.|
  Fly   430 SPT-RCNSPMSSAQQQANA-------------ISRPSSPAAGTRHS-TYGDRDRSGHHSSVSR-- 477

  Fly   739 TTLYEKTSSTEKTNVIPAETNL--FDRLRM---------------------------ASAVKSSR 774
            |..:....|.|...|:..|..:  .|.||.                           .||..|..
  Fly   478 TPSHSSQKSIEGDVVVVREPRIERRDSLRQERGGGSPRDRGDCGIPPGSPGGNSSGSTSASPSVH 542

  Fly   775 HFPRNVP--SRSTFHSGQTRA---RNNTALEYSGTSGASGDSSH-PGRMSFFSKL---------S 824
            |...:.|  :.|.||...:.:   .|.:.:..:.:.|..|...: ||...:.::|         |
  Fly   543 HRANSGPTIAISMFHDPDSNSVVNPNGSPMMNNSSPGMPGSPCNTPGGQLWKTRLTNIKNSFLGS 607

  Fly   825 SRFSKR--PTIADEA-----AKPRVLRFTW--SMKTTSPLMPDQIMQKIREVLDQNNCDYEQRER 880
            .||.:|  ...|||.     :.|.:.:.:|  ::.||                       |:.|.
  Fly   608 PRFHRRKMQVSADEVHLTPESSPELTKRSWFGNLITT-----------------------EKDET 649

  Fly   881 FVLWCVHGDP------------------------------------NTDSLVQWEIE-------V 902
            |.: .|.|.|                                    |...:.|..::       :
  Fly   650 FTI-LVKGKPIATVKAHLIHAFLSMAELSHSVVSPTSFRVEYKRNGNGPVMFQRHVKFQVDISAI 713

  Fly   903 CKLPRLS--LNGVRFKRISGTSIGFKNIASRIAFDLKLXLNQTNNEGNAAATASRPTDPTDTMTT 965
            ||...::  |..:.|..:||....|:.|...|               .:...:.|...|:...|.
  Fly   714 CKQGDIADMLFALTFTLLSGNIRRFRRICEHI---------------QSQVCSKRFPGPSSPPTV 763

  Fly   966 TNCRRPSNDSTSRLSELSLLCRSLTSQQGSQRRKKSRLSTGGSEDQKKSNSLLSAFQMYSPFSSK 1030
            |:..:..::|:|        |.|::|::.|.:|:.       .|:..:::|:.|       :.|.
  Fly   764 TSVTQAVSESSS--------CGSVSSERLSYKRQV-------IENDMENDSIFS-------YKSG 806

  Fly  1031 ENMQSSEEVEDLHVIDTQPGHSVDVPLFADFSPINPIMEEDAEGVEGGKTSE------AKVISGG 1089
            ...::|       ..:....:.||:|    .|||  .:..::|..|..:..|      |..:||.
  Fly   807 NGRRAS-------TTNNNNANPVDIP----GSPI--AVRSNSETAEHERNRELQSERQATTMSGS 858

  Fly  1090 S 1090
            :
  Fly   859 A 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	133/251 (53%)
		S_TKc	253..504	CDD:214567	133/250 (53%)
		UBA_MARK_Par1	525..563	CDD:270522	11/40 (28%)
		MARK1-3_C	839..936	CDD:213381	21/143 (15%)
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	134/252 (53%)
		S_TKc	18..269	CDD:214567	133/250 (53%)
		UBA_BRSK	298..350	CDD:270525	15/51 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D302185at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.920