DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment par-1 and snrkb

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_957127.1	Gene:	snrkb / 393806	ZFINID:	ZDB-GENE-040426-1724	Length:	741	Species:	Danio rerio

Alignment Length:	727	Identity:	211/727 - (29%)
Similarity:	327/727 - (44%)	Gaps:	134/727 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 GKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKL 315
            |.|.|.:|:|||:||.||||:|:.||:.||:|:||||:|:..:...|.:|||.||::.|||:|:|
Zfish    14 GLYDLDRTLGKGHFAVVKLARHVFTGQLVAVKVIDKTKLDDLATGHLLQEVRCMKLVQHPNVVRL 78

  Fly   316 FQVIETEKTLYLIMEYASGGEVFDYLVLH-GRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAE 379
            ::||:|:..||||:|...||:::||::.| |.:.|..|:|.|.|||.|:.|||:..::|||||.|
Zfish    79 YEVIDTQTKLYLILELGDGGDMYDYILRHEGGVAEDTAKVHFAQIVRAIAYCHRLHVVHRDLKPE 143

  Fly   380 NLL-LDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTL 443
            |:: ...:..:|:.||||||.|.||:.|.|.|||..|:|||:..|::||.|.||:||||||||.|
Zfish   144 NVVFFRQQGTVKLTDFGFSNHFKPGTMLMTSCGSLAYSAPEILLGEEYDAPAVDIWSLGVILYML 208

  Fly   444 VSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMN--- 505
            |.|..||..:...|....::..:|.:|.::|..|::|:.:.|..:|||||||..|....|:.
Zfish   209 VCGHPPFQETNDSETLIMIMDCRYTVPNHISAQCKDLISRMLQRDPAKRASLAEIESHPWLQGVD 273

  Fly   506 ---MGFEEDELKPYIEPKADLADPKR--IEALVAMGY-NRSEIEASLSQVRYDDVFATYLLLGRK 564
               .||   ...|....::.|.:...  ::|:.:... .|..|:.:|...||:.:.|||.|||.:
Zfish   274 PSPAGF---TAAPLTSHRSLLPEEHEFILQAMTSGSIAGRDAIQEALEADRYNHITATYYLLGER 335

  Fly   565 ---------STDPESDGSRSGSSLSLRNIS---------GNDAGANAGSASVQSP-THRGVHRSI 610
                     |..||...::...|..|..:|         |....|.|...|:.:. ..|||..|.
Zfish   336 LLRDKQEQSSLTPEQRNTQRPISEPLDLVSQVPRTDTLRGTPLSALAPLGSLSTGYVRRGVSESG 400

  Fly   611 SASSTKPSRRASSGVGPTNAAATVAAATGAVGAVNPSNNYNAAGSAADRASVGSNFKRQNTIDSA 675
            ...:.|.:|..:|.....:.|              |..:.|......|:.:|.|....|...:..
Zfish   401 DLLAPKANRHDNSFSDFCSTA--------------PCLSLNMRPLPPDQPTVKSLGALQQICEEE 451

  Fly   676 TIKENT-ARLAAQNQRPASATQKMLTTADTTLNSPAKPRTATKYDPTNGNRTVSGTSGIIPRRST 739
            ..::.. .::|.....|..:|...|..:.|:|.|..:.||........||             ..
Zfish   452 EEEDEVKVKMAPGKLGPLPSTDLSLKPSRTSLQSEPQMRTGRHSSKGMGN-------------CE 503

  Fly   740 TLYEKTSSTEKTNVIPAETNLFDRLRMASAVKSS--RHF----PRNVPSRSTFHSGQTRARNNTA 798
            ||.|:....|:.:....|..  ..|.:.|::.|.  .|.    |:..|....|        |:|
Zfish   504 TLAEEEEELEEGSESIEEHK--KPLDLVSSISSGTVEHQVEMPPKTEPQVEEF--------NHT- 557

  Fly   799 LEYSGTSGASGDSSHPGR---MSFFSKLSSRFSKR-------PTIADEAAKPR--VLRFTWSMKT 851
                         ..||:   .|.|:.:|....::       |.:......||  |::..|..:.
Zfish   558 -------------KQPGKGNDKSVFTHVSLSLEEQEGEEIQGPNVDGPLPAPRLDVVQCCWGQRE 609

  Fly   852 TSPLMPDQIMQKIREVLDQNNCDYEQR---ERFVLWCVHGDPNTDSLVQWEIEVCKLPR-----L 908
            .|           :::|:.||....:.   |..|:....|.|.:            |||     |
Zfish   610 PS-----------KDILENNNNTLAKSRLLEAGVISTPCGSPRS------------LPRNHCVDL 651

  Fly   909 SLNGVRFKRISG 920
            ..:||..::..|
Zfish   652 GPDGVEMRKTVG 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	119/253 (47%)
		S_TKc	253..504	CDD:214567	119/252 (47%)
		UBA_MARK_Par1	525..563	CDD:270522	11/40 (28%)
		MARK1-3_C	839..936	CDD:213381	19/92 (21%)
snrkb	NP_957127.1	STKc_SNRK	12..269	CDD:270976	120/254 (47%)
		S_TKc	16..269	CDD:214567	119/252 (47%)
		UBA_SNRK	290..335	CDD:270524	13/44 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910