DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment par-1 and 4921509C19Rik

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_941057.1	Gene:	4921509C19Rik / 381393	MGIID:	2685851	Length:	640	Species:	Mus musculus

Alignment Length:	662	Identity:	190/662 - (28%)
Similarity:	290/662 - (43%)	Gaps:	183/662 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 RWRATE-------------EHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGS 293
            ||:|.:             ||   |:::.|:|:|.|.:||||.||.|..:|||||:.|::.|  |
Mouse     3 RWQACQDLRSNTFEDAALTEH---YEILTTLGQGTFGEVKLASHLVTQTKVAIKILPKSRKN--S 62

  Fly   294 LQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQ 358
            |.:  .|:.|||.||||:|:||..:|:|.:.:::::|:|.|||:...:...|.:.|.|....|:|
Mouse    63 LVQ--PEIEIMKSLDHPHIIKLLHIIDTTRNIFIVLEHAVGGELMSRIEEFGYLAEVECHRLFKQ 125

  Fly   359 IVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQG 423
            :|.|:||||:|.|:|||||.||:|||...|:|:.|||...:...|.||.||||:.||.|||||:.
Mouse   126 LVYALQYCHEKGIVHRDLKPENILLDHRGNVKLTDFGLGTKIIMGQKLVTFCGTLPYCAPELFED 190

  Fly   424 KKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLN 488
            :.|||...|||||||:||.:.:|.|||:|.:...::::::.|||...|.:|.:...::.|.|.:|
Mouse   191 RGYDGRATDVWSLGVVLYFMATGCLPFNGYSYEAIKQKIIAGKYPRSFSLSPELWEVIAKLLTVN 255

  Fly   489 PAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLA-------DPKRIEALVAMGYNRSEIEASL 546
            |.:|.::..|...||:.   .::|..|     |.|.       ||..:..:..||||..||..||
Mouse   256 PGERPTVHDIARFKWLK---PDNEASP-----ASLGENIESHPDPSIMVLMGVMGYNPGEIRESL 312

  Fly   547 SQVRYDDVFATYLLLGR---------------------KSTDPESDGSRS---------GSSLSL 581
            .:.::|.|.||||:|.:                     :||:|......|         .|:.||
Mouse   313 REKKFDQVMATYLMLKQQSAWENKTTKKPDPRLCDRMLRSTEPTIKNQTSVRRASSVPTHSTFSL 377

  Fly   582 RNISGN-DAGANAGSASVQSPT------------------------HRGVHRSISASSTKPSRRA 621
            .|.|.: :.|.....:....||                        .|.:......|.|  |..:
Mouse   378 PNESESLEKGKRTTMSHSMPPTRNCFNEETTPLHSICPQLVQKAHYRRSIWGETEISDT--SEES 440

  Fly   622 SSG----------------VGPTNAAATVAAATGAVGAVNPSNNYNAAGSAADRASVGSNFKRQ- 669
            |:|                :|.:.|.:|.:.:.|:...|:..:.     |..:....|:|..|:
Mouse   441 STGESLEHPSLKIHTLQTSMGVSKAGSTYSKSKGSSQCVSSHHT-----SVEEDQCEGTNISREI 500

  Fly   670 --------------------NTIDSATIKENT-------ARLAAQNQRPASATQKMLTTADTTLN 707
                                .|..|..|. ||       :|..|:.:.||...::...::..||.
Mouse   501 NPPLSPVSPQENLMGQLHIVTTAGSMDIM-NTQVTSPPFSRKEAKGEGPALQQRESRPSSPNTLQ 564

  Fly   708 SPAKPRTAT---------------------------------KYDPTNGNRTVS-------GTSG 732
            .....|..|                                 :..||| ||.::       |:.|
Mouse   565 GHLHGRRQTVPQAPFQRRVWRTLRNGLIRGLRTLCCCLPIERRVHPTN-NRDLAVSQKSHGGSHG 628

  Fly   733 IIPRRSTTLYEK 744
            |...|.|.|.||
Mouse   629 IRAFRGTVLPEK 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	110/251 (44%)
		S_TKc	253..504	CDD:214567	110/250 (44%)
		UBA_MARK_Par1	525..563	CDD:270522	17/37 (46%)
		MARK1-3_C	839..936	CDD:213381
4921509C19Rik	NP_941057.1	STKc_AMPK-like	23..270	CDD:270905	110/253 (43%)
		UBA_MARK_Par1	290..328	CDD:270522	16/37 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	359..399		7/39 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..509		8/49 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	531..576		9/44 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	617..640		6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810