DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment par-1 and Sik3

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_001188969.1	Gene:	Sik3 / 37152	FlyBaseID:	FBgn0262103	Length:	1471	Species:	Drosophila melanogaster

Alignment Length:	1169	Identity:	310/1169 - (26%)
Similarity:	459/1169 - (39%)	Gaps:	314/1169 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 TSSAKGSPNMQMRSSAPMRWRATEE---------HIGKYKLIKTIGKGNFAKVKLAKHLPTGKEV 279
            |:...|.......||.|..::....         .:|.|:|.|||||||||.||||.::.|..:|
  Fly     3 TTPTAGPAAAPPTSSTPQNYKVPSTSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKV 67

  Fly   280 AIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLH 344
            ||||||||.||...|.|.|||:.|:|.|.||:|.:|::|:|::..:||:.|||..||:||:||.:
  Fly    68 AIKIIDKTCLNEEYLNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVAN 132

  Fly   345 GRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTF 409
            |||||.||...|.|:||||.|||::.::||||||||:|||.::|||:|||||||.:..|:.|.|:
  Fly   133 GRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTW 197

  Fly   410 CGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMS 474
            ||||||||||:|||.:||||:.|:|||||:||.||.|:|||||.|:.||:.||:.||:||||:||
  Fly   198 CGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMS 262

  Fly   475 TDCENLLRKFLVLNPAKRASLETIMGDKWMN---MGFEEDELKPYIEPKADLA------------ 524
            .:||.|:|..||:.|.:|.:::.|:..:|::   ...:|.|....:.|.:...
  Fly   263 QECEQLIRNMLVVEPDRRYTIKQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSA 327

  Fly   525 --DPKRIEALVAM------GYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPESDGSRSGSSLSL 581
              .|.:::::|..      |.....|..|:.:.|:|:::|.|.||..|......:..|.....||
  Fly   328 SDSPPQLDSVVMTHMLQLPGLTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHASL 392

  Fly   582 RNISGNDAGANAGSASVQSPTHRGVHRSISASSTKPSRRASSGVG-------------------- 626
            ............|......|..:.....:|..|...:..::.|.|
  Fly   393 AYSRSRKTSITTGVVDRSEPVKQESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLA 457

  Fly   627 -----PTNAAATVAAATGAVGAVNPSNNYNAAGSAADRASVGS------NFK------------- 667
                 |.||....|.|.|.|...|...:....|..|...::.:      :||
  Fly   458 RSNDPPVNAQHLSAHAGGGVNGANTRRHTVGPGDVAHEQALANPNVPPIDFKCPPQCSDPTQPVP 522

  Fly   668 ---------RQNTIDSATIKE-------------------------------------------- 679
                     :...:.:.|||:
  Fly   523 YYPVNLPMLQNQPLHNLTIKDQHLLKPPVVMGASSFGRRASDGGANLHIYYPATGTVVGPAQGQQ 587

  Fly   680 ------------NTARLAAQNQRP---ASATQKMLTTADTT------LNSPAKPRTATK------ 717
                        .|..||.|...|   .|..|......:.|      |.|..:.|..|:
  Fly   588 MDTAGYYINPNCGTDPLAVQELSPLNEQSVAQMQCCQENATGECNEELQSYMQKRGGTQRHTVGC 652

  Fly   718 -YDPTNGNRTVSGTSGIIPRRSTTLYEKTSS----TEKTNVIPAE--TNLFDRLR---MASAVKS 772
             .|.:..:.:.:|:....|..|:.:.::.:.    ||:..|||.|  ..:..|::   :...:||
  Fly   653 TEDLSVAHGSGAGSQSQAPTTSSNMRQRRTGLLTVTERPPVIPPEIIREVESRMKRDYLPPTLKS 717

  Fly   773 SRHFPRNVPSRSTFHSGQTRARNNTALEYSGTSGASGDSSHP------GRMSFFSKLSSRF---- 827
            ....|.|    .|:..|       .||....:.|.|...|.|      |.:...:..:.|.
  Fly   718 LSQSPPN----GTYPVG-------AALPMGMSKGLSPPHSLPLVAAAGGSVPLVAPNNRRIHRVV 771

  Fly   828 -SKRPTIADEAAKPR---VLRFTWSMKT--TSPLMPDQIMQKIREVLDQNNCDYEQRERFVLWC- 885
             ||.||:.:.|...|   |.|.:...|:  ..||...|.:||          ...||...|...
  Fly   772 HSKLPTVQEGATIGRYSPVRRASEGSKSQFQGPLQECQSLQK----------GIAQRNFLVAPSP 826

  Fly   886 -------------VHGDPNTDSLVQ----WEIEV---------CKLPRLSLNGVRFKRISGTSIG 924
                         :||.|.....:.    .:|||         ..|.||    |:.:|:| ..|.
  Fly   827 PLLENSISLPGSPIHGKPGMGLQLALRRGHDIEVPPEAIKNLMPALDRL----VKEQRVS-FEIA 886

  Fly   925 FKNIASRIA-FDLKLXLNQTNNEGNAAATASRPTDPTDTMTTTNCRRPSNDSTSRLSELSLLCRS 988
            .|.|::.:. .||...|....:..:|||.:....|                 .|..:.|
  Fly   887 NKIISTHVVPMDLAPLLGLAAHASSAAAVSGGHLD-----------------QSHFTHL------ 928

  Fly   989 LTSQQGSQRRKKS------RLSTGGSEDQKKSNSLLSAFQM----------YSPFSSKENMQSSE 1037
              .||..|:...|      .:..||:.:.    ||.||.||          |.|.:.....|..:
  Fly   929 --QQQQQQQHMLSFSVSPLSMPQGGAVNA----SLTSAKQMFGQPICGYTQYQPMTLALQPQHQQ 987

  Fly  1038 EVE------DLHVIDTQPGHSVDVPLFA-----DFSPINPIMEEDAEGVEGGKTSEAKVISGGSG 1091
            ::.      :|...::........|:|:     ..|| ||.:    .|..||.:...::..|.||
  Fly   988 QLVGQFSSINLGASNSNSSSGCQSPVFSTSFSGSCSP-NPYL----PGAAGGSSPLHQITKGISG 1047

  Fly  1092 QKVKGDGGGGGGGNRLKRNIKHTGSLIVRKLTAGRHNDADKKGAIRKKDKEQQEVADTDKERPT 1155
            ...     |..||:            |.|..:|.....|....|.:..|...........::||
  Fly  1048 LST-----GCAGGS------------ITRGTSAASEGAAAAAAANQPLDLSMDVCGGVMDQQPT 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	147/251 (59%)
		S_TKc	253..504	CDD:214567	147/250 (59%)
		UBA_MARK_Par1	525..563	CDD:270522	11/43 (26%)
		MARK1-3_C	839..936	CDD:213381	27/129 (21%)
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	147/251 (59%)
		S_TKc	41..292	CDD:214567	147/250 (59%)
		UBA_SIK	335..380	CDD:270523	11/44 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5061
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840