DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment par-1 and Nuak1

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_001100244.1	Gene:	Nuak1 / 299694	RGDID:	1309956	Length:	661	Species:	Rattus norvegicus

Alignment Length:	678	Identity:	198/678 - (29%)
Similarity:	296/678 - (43%)	Gaps:	166/678 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 SGVAPTVNKNVLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAPMRWRATEEHIGK------YKLIK 257
            :|..|.|...:       |.:.::..:.|..:|      ..|.:....:.|..|      |:|.:
  Rat     9 AGDGPAVETGL-------PGSPREVVAGATAAP------VEPRKPHGVKRHHHKHNLKHRYELQE 60

  Fly   258 TIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPG-SLQKLFREVRIMKMLDHPNIVKLFQVIET 321
            |:|||.:.|||.|....:|:.||||.|.|.::... .:..:.||:.||..|:||:|:.:::|.|.
  Rat    61 TLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDELDMVHIRREIEIMSSLNHPHIISIYEVFEN 125

  Fly   322 EKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSE 386
            :..:.:||||||.||::||:....|:.|:|.|..||||||||.|||:..::|||||.||:|||..
  Rat   126 KDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDN 190

  Fly   387 LNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFD 451
            .||||||||.||.:.....|.||||||.||:||:..|:.|.|||||.|:|||:||||:.|::|||
  Rat   191 CNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLIYGTMPFD 255

  Fly   452 GSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEE------ 510
            |...:.|..::..|:||.|...| |...|:|..|::||.:||::|.|....|:|.|::.
  Rat   256 GFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDRRATIEDIANHWWVNWGYKSSVCDCD 319

  Fly   511 ---DELKPY-------------IEPKADL---ADPKRIEALV--AMGYNRSEIEASLSQVRYDDV 554
               |...|.             ::.:||.   |.|...|.::  .....:|:.|....|...|.:
  Rat   320 ALPDSESPLLARIIDWHHRSTGLQAEADAKMKAKPGASEVVLERQRSLKKSKKENDFPQSGQDSL 384

  Fly   555 FATYLLLGRK-----------------ST------------------------------DPESDG 572
            ..:...|..|                 ||                              .||:.|
  Rat   385 PESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGIVGPALPSPFKMEQDLCRTAIPLPGSPEAQG 449

  Fly   573 SRSGSSLSLRN--------------------------------ISGNDAGANAGSASVQSPTHRG 605
            | || .|||:.                                :..|:...::|.:|......||
  Rat   450 S-SG-KLSLKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNNVIISSGLSSPPPDPARG 512

  Fly   606 VHRSISA---SSTKPSRRASSGVGPTNAAATVAAATG----AVGAVNP--------SNNYNAAGS 655
            ...|:|.   ...|.|.|.|.|       ||..|.||    .:.:::|        |.:|:...|
  Rat   513 TSHSLSCRRKGILKHSSRYSDG-------ATDPALTGPEIPTLESLSPPGVPSDGISRSYSRPSS 570

  Fly   656 AADRASVGSNFKRQNTIDSATIKENTARLAAQNQRPASATQKMLTTAD--TTLNSPAKPRTATKY 718
            .....||.|:    ::.|...::||  |.|.|..|...:.:..|...|  |..|.| :|:...:|
  Rat   571 IISDDSVLSS----DSFDLLDLQEN--RPARQRIRSCVSAENFLQLQDFETPHNRP-RPQYLKRY 628

  Fly   719 DPTNGNRTVSGTSGIIPRRS--TTLYEK 744
                .||....:..::....  |.:|:|
  Rat   629 ----RNRLADSSFSLLADMDDVTQVYKK 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	120/258 (47%)
		S_TKc	253..504	CDD:214567	119/251 (47%)
		UBA_MARK_Par1	525..563	CDD:270522	7/39 (18%)
		MARK1-3_C	839..936	CDD:213381
Nuak1	NP_001100244.1	STKc_NUAK	54..307	CDD:270975	119/253 (47%)
Nuak1	NP_001100244.1	S_TKc	56..307	CDD:214567	119/251 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910