DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment par-1 and Nuak2

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_001007618.1	Gene:	Nuak2 / 289419	RGDID:	1359167	Length:	630	Species:	Rattus norvegicus

Alignment Length:	732	Identity:	220/732 - (30%)
Similarity:	325/732 - (44%)	Gaps:	169/732 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 HTPGSGVAPTVNKNVLSTHSAHPSA---IKQRTSSAKGSPNMQMRSSAPMRWRATEEHIGKYKLI 256
            |..|: :||:.  :.|:|.||.|.|   ||        ||...|:..|..|.........:|:.:
  Rat     7 HRRGN-LAPSA--SALATESARPLADRLIK--------SPKPLMKKQAVKRHHHKHNLRHRYEFL 60

  Fly   257 KTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQL-NPGSLQKLFREVRIMKMLDHPNIVKLFQVIE 320
            :|:|||.:.|||.|:. .:|:.||||.|.|.:: :...|..:.||:.||..|:||:|:.:.:|.|
  Rat    61 ETLGKGTYGKVKKARE-SSGRLVAIKSIRKDKIKDEQDLLHIRREIEIMSSLNHPHIIAIHEVFE 124

  Fly   321 TEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDS 385
            ....:.::|||||.|:::||:....|:.|::||..|||||||:.||||..|:|||||.||:|||:
  Rat   125 NSSKIVIVMEYASRGDLYDYISERPRLNERDARHFFRQIVSALHYCHQNGIVHRDLKLENILLDA 189

  Fly   386 ELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 450
            ..||||||||.||.:..|..|.||||||.||:||:..||.|.|||||.|||||:||.||.|::||
  Rat   190 SGNIKIADFGLSNLYHKGKFLQTFCGSPLYASPEIVNGKPYVGPEVDSWSLGVLLYILVHGTMPF 254

  Fly   451 DGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGF-----EE 510
            ||...:.|.:::..|.||.|...|..| .|:|..|::||.:||:||.:....|:|.|:     |:
  Rat   255 DGQDHKTLVKQISSGAYREPCKPSDAC-GLIRWLLMVNPIRRATLEDVASHWWVNWGYSTRIGEQ 318

  Fly   511 DELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPESDGSRS 575
            :.|:....|..|..                  .||:         |.:|   |:|:.|..:....
  Rat   319 EALREGGHPSGDSG------------------RASM---------ADWL---RRSSRPLLENGAK 353

  Fly   576 GSSLSLRNISGNDAGANAGSASVQSPTHRGVHRSISASSTKPSRRASSGVGPTNAAATVAAATGA 640
            ..|...:::.|   |.:.|.         |:.|.   .|.|.||:.:      :.|.|:
  Rat   354 VCSFFKQHVPG---GGSTGP---------GLERQ---HSLKKSRKEN------DMAQTL------ 391

  Fly   641 VGAVNPSNNYNAAGSAADRAS-VGSN--------FKRQNTIDSATIKENTARLAAQNQRPASATQ 696
                  .|:     .|.|.:| .|.|        .|::.:..|..::|     ..|..||.|
  Rat   392 ------QND-----PAEDTSSRPGKNSLKLPKGILKKKASPSSGEVQE-----GPQELRPVS--- 437

  Fly   697 KMLTTADTTLNSPAKPRTATKYDPTNGNRTVSGTSGIIPRRSTTLYEKTSSTEKTNVIPAETNLF 761
                      |:|.:|..|....|..|....|      .:|.:..|.....:|...::.| .::|
  Rat   438 ----------NTPGQPVPAIPLLPRKGILKKS------RQRESGYYSSPEPSESGELLDA-GDVF 485

  Fly   762 ---DRLRMASAVKSSRHFPRNVPSRSTFHSGQTRARNNTALEYSGTSGASGDSSHPGRMSFFSKL 823
               |.:...|...|.|...:.:...:...|       .||||  ||:           .|.|..|
  Rat   486 VSGDPMEQKSPQASGRLHRKGILKLNGKFS-------RTALE--GTA-----------PSTFGSL 530

  Fly   824 SSRFSKRPTIADEAAKPRVLRFTWSMKTTSPLMPDQIMQKIREVLDQNNCDYEQRERFVLWCVHG 888
            ....|..||.  .|::|           :..:..|.|:..  |..||.:......|..:..||..
  Rat   531 DQLASPHPTA--RASRP-----------SGAVSEDSILSS--ESFDQLDLPERLPETPLRGCVSV 580

  Fly   889 D-------PNTDSLVQW 898
            |       |.::.|.:|
  Rat   581 DNLRRLEQPPSEGLKRW 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	121/252 (48%)
		S_TKc	253..504	CDD:214567	121/251 (48%)
		UBA_MARK_Par1	525..563	CDD:270522	4/37 (11%)
		MARK1-3_C	839..936	CDD:213381	13/67 (19%)
Nuak2	NP_001007618.1	PKc_like	53..307	CDD:304357	121/255 (47%)
		S_TKc	57..307	CDD:214567	121/251 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	361..504		40/205 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..566		15/70 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910