DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment par-1 and Map3k2

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_036076.2	Gene:	Map3k2 / 26405	MGIID:	1346873	Length:	619	Species:	Mus musculus

Alignment Length:	496	Identity:	128/496 - (25%)
Similarity:	195/496 - (39%)	Gaps:	128/496 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PEAL---PADSVSNGTASNVAAPAAPVSSATNAVPPLAAVSSTTATYATNSISTSSHSVKDQQQQ 74
            ||.|   |..:......|.|..|....||     ||...:.......|.|...||.:|..:...:
Mouse   136 PEDLNNTPLGAERKKRLSVVGPPNRDRSS-----PPPGYIPDELHQIARNGSFTSINSEGEFIPE 195

  Fly    75 QQQQQHDSANANIVSLPPTTTPVANTNTMMPIVTSSNSATSNSTAATPTPASGAAATGGVGSVSQ 139
            ...|..|              |::        ::|..::.|.|..:..:|..|.:.
Mouse   196 SMDQMLD--------------PLS--------LSSPENSGSGSCPSLDSPLDGESY--------- 229

  Fly   140 GPATVSASAANTNHSHQ---------------------HSHQHHHHVANNMTTDG------ARLS 177
             |.:....|.:...:||                     ..|..:||...|   ||      ||.:
Mouse   230 -PKSRMPRAQSYPDNHQEFTDYDNPIFEKFGKGGTYPRRYHVSYHHQEYN---DGRKTFPRARRT 290

  Fly   178 SNNS--AVVASSAINHHHHHTPGSGVAPTVNKNVLSTHSAHPSAIKQRTSSAKGSPNMQM----- 235
            ...|  :.|:.|..:|....:.||.|         .|.....|.|::|.|.. .:|.:.:
Mouse   291 QGTSFRSPVSFSPTDHSLSTSSGSSV---------FTPEYDDSRIRRRGSDI-DNPTLTVTDISP 345

  Fly   236 --RS-SAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGS---- 293
              || .||..||          |.|.:|:|.|.:|.|...:.||:|:|:|   :.|.||.|
Mouse   346 PSRSPRAPTNWR----------LGKLLGQGAFGRVYLCYDVDTGRELAVK---QVQFNPESPETS 397

  Fly   294 --LQKLFREVRIMKMLDHPNIVKLFQVIE--TEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARV 354
              :..|..|::::|.|.|..||:.:..:.  .||||.:.|||..||.:.|.|..:|.:.|...|.
Mouse   398 KEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRK 462

  Fly   355 KFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFC--------- 410
            ..|||:..|.|.|...|:|||:|..|:|.||..|||:.|||.|      .:|.|.|
Mouse   463 YTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGAS------KRLQTICLSGTGMKSV 521

  Fly   411 -GSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 450
             |:|.:.:||:..|:.| |.:.|:||:...:..:::...|:
Mouse   522 TGTPYWMSPEVISGEGY-GRKADIWSVACTVVEMLTEKPPW 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	73/217 (34%)
		S_TKc	253..504	CDD:214567	73/216 (34%)
		UBA_MARK_Par1	525..563	CDD:270522
		MARK1-3_C	839..936	CDD:213381
Map3k2	NP_036076.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..44
		PB1_Mekk2_3	44..122	CDD:99726
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..168		11/36 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..247		11/77 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..355		17/75 (23%)
		STKc_MEKK2	353..616	CDD:270818	76/229 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000