DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment par-1 and Sik2

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_848825.2	Gene:	Sik2 / 235344	MGIID:	2445031	Length:	931	Species:	Mus musculus

Alignment Length:	940	Identity:	281/940 - (29%)
Similarity:	417/940 - (44%)	Gaps:	247/940 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 AKGSPNMQMRSSAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNP 291
            |.|..::|   ..|:|       :|.|.:..|:||||||.|||.:|..|..|||||||||:||:.
Mouse     4 ADGPRHLQ---RGPVR-------VGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDA 58

  Fly   292 GSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKF 356
            .:|:|::|||:||||||||:|:||:||:||:..|||:.|||..||:||||..|||:.|.|||.||
Mouse    59 VNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKF 123

  Fly   357 RQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELF 421
            .||:|||.|||.::::||||||||||||:.:|||||||||.|.|..|..|.|:||||||||||:|
Mouse   124 WQILSAVDYCHGRKVVHRDLKAENLLLDNNMNIKIADFGFGNFFKTGELLATWCGSPPYAAPEVF 188

  Fly   422 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLV 486
            :|::|:||::|:||:||:||.||.|:|||||.||..||:|||.|::|||::||.|||:|:|:.||
Mouse   189 EGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLV 253

  Fly   487 LNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLADP-------KRIEALVAMGYNRSEIEA 544
            |:|:||.|:..|...|||.:  |....:|.:.|:....:|       :.:..:.::|.::.:...
Mouse   254 LDPSKRLSIAQIKEHKWMLI--EVPVQRPILYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTVE 316

  Fly   545 SLSQVRYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNISGNDAGANAGSASVQSPTHRG---V 606
            ||....|:...|.|.||..:                                   ..:||.   |
Mouse   317 SLQNKSYNHFAAIYFLLVER-----------------------------------LKSHRSSFPV 346

  Fly   607 HRSISASSTKPSRRASSGVGPTNAAATVAAA--TGAVGAVNPSN-------------NYNAAGSA 656
            .:.:.....:||         |.|..|||.|  .|....::|.|             |..|....
Mouse   347 EQRLDGRQRRPS---------TIAEQTVAKAQTVGLPVTLHPPNVRLMRSTLLPQASNVEAFSFP 402

  Fly   657 ADRASVGSNFKRQNTIDSATIKEN----------TARLAAQNQRPASATQKMLTTADTTLNSPAK 711
            .......:.|..:..:|  |.|.|          ..|...|: .|:|   .|.|:.|..|.:..:
Mouse   403 TSSCQAEAAFMEEECVD--TPKVNGCLLDPVPPVLVRKGCQS-LPSS---MMETSIDEGLETEGE 461

  Fly   712 PRTATKYDPTNGNRTVSGT-SGIIPRRSTTLYEKTSSTEKTNVIPAETNLFDRLRMASAVKSSRH 775
                .:.||:........| ||   :|..||.|.|:   :..|:|....:|.
Mouse   462 ----AEEDPSQAFEAFQATRSG---QRRHTLSEVTN---QLVVMPGAGKMFS------------- 503

  Fly   776 FPRNVPSRSTFHSGQTRARNNTALEYSGTSGASGDSSHPGRMSFFSKLSSRFSKRPTIAD----E 836
                             ..:|.:||       |.||.:.  |....:..:.....|::.|    .
Mouse   504 -----------------MSDNPSLE-------SVDSEYD--MGSAQRDLNFLEDSPSLKDIMLAN 542

  Fly   837 AAKPRVLRFTWSMKTTSPLMPDQIMQKIREVLDQNNCDYEQRERFVLWCVHGDPN-TDSLVQWEI 900
            ...||:.....|::..:|.|.....|| ||..:::...:.:..|      ..|.: |..:|.:..
Mouse   543 QPSPRMTSPFISLRPANPAMQALSSQK-REAHNRSPVSFREGRR------ASDTSLTQGIVAFRQ 600

  Fly   901 EVCKLPR----LSLNGVRFKRISGTSIGFKNIASRIAFDLKLXLNQTNNEGNAAATASRPTDPTD 961
            .:..|.|    |.||.|                       :|...|..:  ||        |||.
Mouse   601 HLQNLARTKGILELNKV-----------------------QLLYEQMGS--NA--------DPTL 632

  Fly   962 TMT-------TTNCRRPSNDSTSRLSELSLLCRSLTSQQGSQRRKKSRLSTGGSEDQKKSNSLLS 1019
            |.|       :::|  |..:.:.:...:|.|..|:..|...|:    .|.|...:.:.:..:||.
Mouse   633 TSTAPQLQDLSSSC--PQEEISQQQESVSSLSASMHPQLSPQQ----SLETQYLQHRLQKPNLLP 691

  Fly  1020 AFQMYSPFSSKENMQSSEEVEDLHVI------------------------DTQPGHSVDV----- 1055
            ..|...|...||..:|.|:....|.:                        .:.||.|..:
Mouse   692 KAQSPCPVYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPGPSQQLALPHQ 756

  Fly  1056 ---------PLFADFSPINPIMEEDAEGVE 1076
                     |.|:....::|::|..:|.::
Mouse   757 ETPLTSQQPPSFSLTQALSPVLEPSSEQMQ 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	156/251 (62%)
		S_TKc	253..504	CDD:214567	156/250 (62%)
		UBA_MARK_Par1	525..563	CDD:270522	9/44 (20%)
		MARK1-3_C	839..936	CDD:213381	19/101 (19%)
Sik2	NP_848825.2	STKc_SIK	19..271	CDD:270973	156/251 (62%)
		S_TKc	20..271	CDD:214567	156/250 (62%)
		UBA_SIK2	297..341	CDD:270592	8/78 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	565..586		5/27 (19%)
		RK-rich region, required for cAMP responsiveness. /evidence=ECO:0000269\|PubMed:29211348	595..624		8/51 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	631..662		6/32 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	744..768		4/23 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	798..842
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810