Protein Alignment par-1 and Mark4

DIOPT Version :10

• Sequence 1: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Sequence 2: NP_758483.1
• Gene: Mark4 / 232944
• MGIID: 1920955
• Length: 752
• Species: Mus musculus
• Alignment Length: 817
• Identity: 382/817 - (46%)
• Similarity: 485/817 - (59%)
• Gaps: 122/817 - (14%)

  Fly   178 SNNSAVVASSAINHHHHHTPGSGVAPTVNKNVLSTHSAHPSAIKQRTSSAKGSPNMQMRS----- 237
            |:.:|:...:..|...|.|.|||                       .||.|| |:...||
Mouse     2 SSRTALAPGNDRNSDTHGTLGSG-----------------------RSSDKG-PSWSSRSLGARC 42

  Fly   238 -----SAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKL 297
                 |.|    ..:.|:|.|:|::|||||||||||||:|:.||:||||||||||||||.|||||
Mouse    43 RNSIASCP----EEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKL 103

  Fly   298 FREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSA 362
            ||||||||.|:||||||||:||||||||||:|||||.||||||||.||||||||||.||||||||
Mouse   104 FREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSA 168

  Fly   363 VQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYD 427
            |.|||||.|:||||||||||||:|.||||||||||||||.|||||||||||||||||||||||||
Mouse   169 VHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYD 233

  Fly   428 GPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKR 492
            |||||:|||||||||||||||||||..|:||||||||||||:|||||||||::||:|||||||||
Mouse   234 GPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKR 298

  Fly   493 ASLETIMGDKWMNMGFEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFAT 557
            .:||.||.|||:|:|:|.:|||||.||:.|..|.||||.:|.|||.|.||:.:|:..:|::|.||
Mouse   299 CTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKEALTNQKYNEVTAT 363

  Fly   558 YLLLGRKSTDPESDGSRSGSSLSLRNISGNDAGANAGSASVQSPTHRGVHRSISASSTKPSRRAS 622
            |||||||:   |..|.|....|:|..:.......|..|:|..|..::|  :..|:|:....||.|
Mouse   364 YLLLGRKT---EEGGDRGAPGLALARVRAPSDTTNGTSSSKGSSHNKG--QRASSSTYHRQRRHS 423

  Fly   623 SGVGPTNAAATVAAATGAVGAVNPSNNYNAAGSAADRASVGSNFK---RQNTIDSATIKENTARL 684
            ...||:.|......:..:.|....... ...|..|..::|||..:   ..:.:.|:....|.|.:
Mouse   424 DFCGPSPAPLHPKRSPTSTGDTELKEE-RMPGRKASCSAVGSGSRGLPPSSPMVSSAHNPNKAEI 487

  Fly   685 AAQNQ----RPASATQKMLTTADTTL--NSPAKPRTATKYDPTNGNRTVSGTSGIIPRRSTTLYE 743
            ..:.:    .|.:....|:|..:|.:  ..|...|.:..   .||....||||.:.|
Mouse   488 PERRKDSTSTPNNLPPSMMTRRNTYVCTERPGSERPSLL---PNGKENSSGTSRVPP-------- 541

  Fly   744 KTSSTEKTNVIPAETNLFDRLRMASAVKSSRHFPRNVPSRSTFHSGQTRARNNTALEYSGTSGA- 807
              :|....::.|...   :|.|:|          |....|||||.||.|.|.    ..||:.|.
Mouse   542 --ASPSSHSLAPPSG---ERSRLA----------RGSTIRSTFHGGQVRDRR----AGSGSGGGV 587

  Fly   808 -SGDSSHP-----------GR----MSFFSKLSSRFSKRPTIADEAAK----------------- 839
             :|..:.|           ||    .:.|:||:|:.::|  :.||..:
Mouse   588 QNGPPASPTLAHEAAPLPSGRPRPTTNLFTKLTSKLTRR--VTDEPERIGGPEVTSCHLPWDKTE 650

  Fly   840 --PRVLRFTWSMKTTSPLMPDQIMQKIREVLDQNNCDYEQRERFVLWCVHGDP-NTDSLVQWEIE 901
              ||:|||.||:|.||...|:.:|..:|:......|...|.:.|:|.|:||.. ..:.|..:|:|
Mouse   651 TAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVE 715

  Fly   902 VCKLPRLSLNGVRFKRISGTSIGFKNIASRIAFDLKL 938
            ||:|||..|.||.|:|::||::.|:.:.:||:.||:|
Mouse   716 VCQLPRPGLRGVLFRRVAGTALAFRTLVTRISNDLEL 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	217/251 (86%)
		UBA_MARK_Par1	525..563	CDD:270522	21/37 (57%)
		MARK1-3_C	839..936	CDD:213381	38/116 (33%)
Mark4	NP_758483.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		13/57 (23%)
		STKc_MARK	58..310	CDD:270974	217/251 (86%)
		UBA_MARK3_4	328..370	CDD:270590	23/41 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	385..615		57/262 (22%)
		MARK4_C	654..752	CDD:213382	39/97 (40%)