Protein Alignment par-1 and Mark1

DIOPT Version :10

• Sequence 1: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Sequence 2: NP_001365805.1
• Gene: Mark1 / 226778
• MGIID: 2664902
• Length: 796
• Species: Mus musculus
• Alignment Length: 829
• Identity: 437/829 - (52%)
• Similarity: 529/829 - (63%)
• Gaps: 133/829 - (16%)

  Fly   203 PTVNKNVLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAPMRWRATEE--HIGKYKLIKTIGKGNFA 265
            ||||:.....|::.....:.....||.|....:.........||:|  |||.|:|.|||||||||
Mouse     8 PTVNERDTENHTSVDGYTETHIPPAKSSSRQNLPRCRNSITSATDEQPHIGNYRLQKTIGKGNFA 72

  Fly   266 KVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIME 330
            |||||:|:.||:|||:||||||||||.|||||||||||||:|:||||||||:||||||||||:||
Mouse    73 KVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVME 137

  Fly   331 YASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFG 395
            ||||||||||||.||||||||||.|||||||||||||||.|:||||||||||||:::||||||||
Mouse   138 YASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFG 202

  Fly   396 FSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRE 460
            ||||||.|:||||||||||||||||||||||||||||||||||||||||||||||||..|:||||
Mouse   203 FSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRE 267

  Fly   461 RVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLAD 525
            |||||||||||||||||||||:|.|||||.||.|||.||.|:|||:|.||:|||||.||:.||:|
Mouse   268 RVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYSEPELDLSD 332

  Fly   526 PKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNISGNDAG 590
            .|||:.:|.||:.|.||..:|...:||:|.|||:|||||  .||.:|..|.||.||...|...:.
Mouse   333 AKRIDIMVTMGFARDEINDALVSQKYDEVMATYILLGRK--PPEFEGGESLSSGSLCQRSRPSSD 395

  Fly   591 ANAGSASVQSPTHRGVHRSISASSTKPSRRASSGVGP---------------------------- 627
            .|  ::::|||.|..|.|||||:  :..||.|...||
Mouse   396 LN--NSTLQSPAHLKVQRSISAN--QKQRRFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWGKD 456

  Fly   628 --------TNAAATVAAATGAVG------AVNPSNNYNAAGSAADRASVGSNFKRQNTIDSATIK 678
                    |..:.:...|:..||      ..:||||..:.||.|          |:||.   ..:
Mouse   457 TARRLGSTTVGSKSEVTASPLVGPDRKKSTASPSNNVYSGGSMA----------RRNTY---VCE 508

  Fly   679 ENTARLAA-QNQRPASATQ---KMLTTADTTLNS---PAKPRTATKYDPTNGNRTVSGTSG---- 732
            .:|.|.|| ||.|.:|.|:   ..:::|.:|:.|   .|:||          ::....|||
Mouse   509 RSTDRYAALQNGRDSSLTEMSASSMSSAGSTVASAGPSARPR----------HQKSMSTSGHPIK 563

  Fly   733 -IIP--RRSTTLYEKTSSTEKTNVIPAETNLFDRLRMASAVKSS----RHFPRNVPSRSTFHSGQ 790
             .:|  :..:..|...|:.::   :||.:      ..|.::.:|    ..|||...||||||..|
Mouse   564 VTLPTIKDGSEAYRPGSAAQR---VPAAS------PSAHSISASTPDRTRFPRGSSSRSTFHGEQ 619

  Fly   791 TRARNNTALEYSG----TSGASGDSSHPGR---MSFFSKLSSRFSKRPTIADEA----------- 837
            .|.|.:.|  |:|    .|..:|..:|..|   ....||::|:|.:|.....||
Mouse   620 LRERRSAA--YNGPPASPSHETGAFAHARRGTSTGIISKITSKFVRRDPSEGEASGRADTARGSS 682

  Fly   838 -------------AKPRVLRFTWSMKTTSPLMPDQIMQKIREVLDQNNCDYEQRERFVLWCVHGD 889
                         ||||.|||||||||||.:.|:.::::||:|||.|.|||||:|||:|:|||||
Mouse   683 GDPKERDKDEGKEAKPRSLRFTWSMKTTSSMDPNDMLREIRKVLDANTCDYEQKERFLLFCVHGD 747

  Fly   890 PNTDSLVQWEIEVCKLPRLSLNGVRFKRISGTSIGFKNIASRIAFDLKL 938
            ...|||||||:|||||||||||||||||||||||.||||||:||.:|||
Mouse   748 ARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 796

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	219/251 (87%)
		UBA_MARK_Par1	525..563	CDD:270522	19/37 (51%)
		MARK1-3_C	839..936	CDD:213381	73/96 (76%)
Mark1	NP_001365805.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41		8/32 (25%)
		STKc_MARK	59..311	CDD:270974	219/251 (87%)
		UBA_like_SF	331..371	CDD:473871	20/39 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..498		31/124 (25%)
		MARK1-3_C	697..794	CDD:213381	73/96 (76%)