DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment par-1 and F49C5.4

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_496679.3	Gene:	F49C5.4 / 186015	WormBaseID:	WBGene00009867	Length:	503	Species:	Caenorhabditis elegans

Alignment Length:	531	Identity:	164/531 - (30%)
Similarity:	267/531 - (50%)	Gaps:	89/531 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 MMPIVTSSNSATSNSTAATPTPASGAAATGGVGSVSQGPATVSA----------SAANTNHSHQH 157
            |.|   |::|.:|:|..:....:.|.|..    :|...|.|.|:          |.|.:..|::.
Worm     1 MQP---STSSPSSSSMGSRMRDSGGLARR----TVRSDPPTYSSILEYNVEEEVSEAESEESYEK 58

  Fly   158 SHQH--HHHVANNMTTDGARLSSNNSAVVASSAINHHHH---HTPGSGVAPTVNKNV--LSTHSA 215
            ..:|  ...|....:.||...:             ||||   :...|.|:..|.|.:  :|..:.
Worm    59 PPEHVPARFVPTQRSDDGGYPA-------------HHHHEAFNRTVSAVSLPVGKQLKDMSEKTQ 110

  Fly   216 HPSAIKQRTSSAKGSPNMQMRSSAPMRWR--ATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKE 278
            :..||.|..:.             |:..:  |....||.|:|.|.:|.|||:||||..|..|.::
Worm   111 YERAILQLNND-------------PVVHKEVALGRRIGFYRLGKELGAGNFSKVKLGVHQLTKEK 162

  Fly   279 VAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVL 343
            ||:||:||.:::..:.:.|.||::.|:.::||||||||:|:||...::|::|||||||::.|:..
Worm   163 VAVKIMDKAKMDAKAQKLLSREIQAMEEMNHPNIVKLFEVVETLTRVHLVIEYASGGELYTYVHE 227

  Fly   344 HGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDT 408
            .|::.|.:|:..|.||||||.:.|.:.|:|||:||||::..|...:|:.|||||........|.|
Worm   228 RGKLTEGDAKPLFAQIVSAVSHMHSRNIVHRDIKAENVMFSSPNTVKLVDFGFSCLVDREQMLRT 292

  Fly   409 FCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYM 473
            ||||||||||||||...|.|..||||:|||:|:.::.|..||...|:.:::..:..|||:||.|:
Worm   293 FCGSPPYAAPELFQDTSYAGELVDVWALGVLLFFMLIGVTPFKAETVPDMKVLITAGKYQIPDYV 357

  Fly   474 STDCENLLRKFLVLNPAKRASLETIMGDKWM-NMGFEEDELKPYIEPKADLADPKR--------- 528
            |.....|::..|..:..:||.::::....|| :..|.:..|......|.|..:.|:
Worm   358 SLLATELIKSMLKTDTGQRADIDSVKKHFWMRDCRFTKSYLSIKATAKIDNEEEKKAIDDKVWKI 422

  Fly   529 ------IEALVAMGYNRSEIEASLSQVRYDDVFATYLL-----------LGRKSTDPESDGS--R 574
                  ::.::        :|.:|.:...|.|..||.:           |.::..:|:...|  .
Worm   423 LNNYGIVKEMI--------VEENLDKGPRDAVVGTYRIVQFQVQSEITRLAKEKDEPQPSSSSFT 479

  Fly   575 SGSSLSLRNIS 585
            :||..|:::::
Worm   480 NGSPTSVKDVN 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	110/251 (44%)
		S_TKc	253..504	CDD:214567	110/250 (44%)
		UBA_MARK_Par1	525..563	CDD:270522	8/63 (13%)
		MARK1-3_C	839..936	CDD:213381
F49C5.4	NP_496679.3	STKc_NIM1	134..388	CDD:270977	112/253 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910