Protein Alignment par-1 and aak-2

DIOPT Version :10

• Sequence 1: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Sequence 2: NP_510710.2
• Gene: aak-2 / 181727
• WormBaseID: WBGene00020142
• Length: 626
• Species: Caenorhabditis elegans
• Alignment Length: 650
• Identity: 203/650 - (31%)
• Similarity: 299/650 - (46%)
• Gaps: 120/650 - (18%)

  Fly   211 STHSAHPSAIKQ-----RTSSAKG--------SPNMQMRSSAPMRWRATEEH--------IGKYK 254
            |...:.||.:.:     |..|||.        |.:...:.|:|....:|::.        ||.|.
 Worm    24 SKSRSQPSGLNRVKNLSRKLSAKSRKERKDRDSTDNSSKMSSPGGETSTKQQQELKAQIKIGHYI 88

  Fly   255 LIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQ---KLFREVRIMKMLDHPNIVKLF 316
            |.:|:|.|.|.|||:..|..|..:||:||:::.::.  ||.   |:.||::.:.:..||:|::|:
 Worm    89 LKETLGVGTFGKVKVGIHETTQYKVAVKILNRQKIK--SLDVVGKIRREIQNLSLFRHPHIIRLY 151

  Fly   317 QVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENL 381
            |||.|...:::|||:.||||:|||:|.|||:|..|||..|:||:|.|.|||:..::|||||.|||
 Worm   152 QVISTPSDIFMIMEHVSGGELFDYIVKHGRLKTAEARRFFQQIISGVDYCHRHMVVHRDLKPENL 216

  Fly   382 LLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSG 446
            |||.:.|:||||||.||..|.|..|.|.||||.|||||:..||.|.||||||||.|||||.|:.|
 Worm   217 LLDEQNNVKIADFGLSNIMTDGDFLRTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCG 281

  Fly   447 SLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEED 511
            :||||...:..|..::..|.:..|.::.....|||...|.::|.|||:::.::..:|........
 Worm   282 TLPFDDEHVPSLFRKIKSGVFPTPDFLERPIVNLLHHMLCVDPMKRATIKDVIAHEWFQKDLPNY 346

  Fly   512 ELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPES------ 570
            ...|..|.:|.:.|   |||:      |...|.....|..::|  |..|||   .||..
 Worm   347 LFPPINESEASIVD---IEAV------REVTEFQRYHVAEEEV--TSALLG---DDPHHHLSIAY 397

  Fly   571 ----DGSR---SGSSLSLRNISGNDAGANAGSASVQSPTHRGVHRSISASSTKPSRRASSGVGPT 628
                |..|   ..:.||:...  .....|.|    ..|.||...| |:||       .||.:.||
 Worm   398 NLIVDNKRIADETAKLSIEEF--YQVTPNKG----PGPVHRHPER-IAAS-------VSSKITPT 448

  Fly   629 NAAATVAAATGAVGAVNPSNNYNAAGSAADRASVGSNFKRQNTIDSATIKENTARLAAQNQRPAS 693
                              .:|..|:|:..::.:     |....|.|.:..|:......:..:...
 Worm   449 ------------------LDNTEASGANRNKRA-----KWHLGIRSQSRPEDIMFEVFRAMKQLD 490

  Fly   694 ATQKMLTTADTTLNSPAKPRTATKYDPTNGNRTVSGTSGIIPRRSTTLYEKTSSTEKTNVIPAET 758
            ...|:|......:.  .|| .|...||              |:.|..||:    .::.:.:....
 Worm   491 MEWKVLNPYHVIVR--RKP-DAPAADP--------------PKMSLQLYQ----VDQRSYLLDFK 534

  Fly   759 NLFDRLRMASAVKSSRHFPRNVPS-----RSTFHSGQTRARNNTA----LEYSGTSGASGDSSHP 814
            :|.|....:::..||||...::|.     |.|..|...:|.:..|    :|....|..|.|.:.|
 Worm   535 SLADEESGSASASSSRHASMSMPQKPAGIRGTRTSSMPQAMSMEASIEKMEVHDFSDMSCDVTPP 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	120/254 (47%)
		UBA_MARK_Par1	525..563	CDD:270522	11/37 (30%)
		MARK1-3_C	839..936	CDD:213381
aak-2	NP_510710.2	STKc_AMPK_alpha	84..339	CDD:270981	122/256 (48%)
		UBA_AID_AMPKalpha	356..419	CDD:270521	19/78 (24%)
		AMPKA_C	462..624	CDD:213378	31/163 (19%)