DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment par-1 and sad-1

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_001076760.1	Gene:	sad-1 / 181471	WormBaseID:	WBGene00004719	Length:	914	Species:	Caenorhabditis elegans

Alignment Length:	936	Identity:	270/936 - (28%)
Similarity:	422/936 - (45%)	Gaps:	136/936 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 KNVLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAK 271
            |.||...::..:|:....||...|.|:.  |:.|:   |..::.|.|||.||:|||....||...
Worm     6 KEVLGEINSKLAAVNNELSSKIMSENIV--STRPV---AQAQYCGPYKLEKTLGKGQTGLVKTGT 65

  Fly   272 HLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGE 336
            |..||::|||||::|.:|:...|||:.||:.|||:::||:::.|:.|.|.:|.|||::|:.||||
Worm    66 HCITGRKVAIKIVNKEKLSESVLQKVEREIAIMKLIEHPHVLHLYDVYENKKYLYLLLEHVSGGE 130

  Fly   337 VFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFT 401
            :|||||..||:..||||..||||:||:.:||...|.|||||.||||||...|||:||||.::...
Worm   131 LFDYLVRKGRLMSKEARKFFRQIISALDFCHAHNICHRDLKPENLLLDERNNIKVADFGMASLQV 195

  Fly   402 PGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGK 466
            .||.|:|.||||.||.||:.:|:||||.:.||||.|||||.|:.|:||||...||.|.|:|.||.
Worm   196 EGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGALPFDDDNLRNLLEKVKRGV 260

  Fly   467 YRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDE---------LKPYIEPKAD 522
            :.||.::..|.::|||..:.::|.||.||..:....|::...:.|.         ::.::.|..|
Worm   261 FHIPHFVPADVQSLLRAMIEVDPGKRYSLADVFKHPWVSGTTKADPELELPMSQVVQTHVIPGED 325

  Fly   523 LADPKRIEALVAMGYNRSE---IEASLSQVRYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNI 584
            ..||..:..:..:|..:.:   |...||.....:....:|||.||...|..:   ..:.:.||..
Worm   326 SIDPDVLRHMNCLGCFKDKQKLINELLSPKHNTEKMVYFLLLDRKRRRPAQE---DDTEIVLRGA 387

  Fly   585 SGN--------DAGANA----GSASVQSPTHRGVHRSISASSTKPSRRASSGVGPTNAAATVAAA 637
            :.|        |:...:    ||.:..||.:   .|.....:.|..|.:|.|..||.:.   .::
Worm   388 AQNNDPPKKRTDSSRTSRYPMGSIADGSPIN---PRKTYGRNQKSGRHSSLGGSPTESP---RSS 446

  Fly   638 TGAVGAVNPSNNYNA-AGSAADR---ASVGSNFKRQNT--IDSATIKENTARLAAQNQRPASATQ 696
            |..:...:.|.:|:| ||...||   ||..:|.....|  :|..|:.|     ||::.|.|...:
Worm   447 TRDLFGSSSSGSYSARAGEDRDRGRSASRSTNSYHYYTQPVDPQTLAE-----AARHVRDAQERR 506

  Fly   697 KMLTTADTTLNSPAKPRTATKYDPTNGNRTVSGTSGIIPRR--------------STTLYEKTSS 747
            :...:...:....:|.|:......::.....|.||. :|.:              |:|:....||
Worm   507 ESRDSGRGSSRKESKDRSDKSASSSSCKNDASSTSS-VPHKYSPPSVMSESVVVSSSTMNSTNSS 570

  Fly   748 TEKTNVIPAETNLFD-----RLRMASAVKSSRHFPRNVPSRSTFHSGQTRARNNTALEYSGTSGA 807
            |.......::|::..     |.::.:...|....||       ||   .|..:|...|.......
Worm   571 TNSLIAGNSQTSIGSTSGPWRSKLNNIKNSFLGTPR-------FH---RRKMSNGTAESDSEDSQ 625

  Fly   808 SGDSSHPGRMSFFSKLSSRFSKRPTIADEAAKPRVLRFTWSMKTTSPLMPD------QIMQKIRE 866
            ..|::...:.|:|..|:|..|....  |....|      ...||.:.:..:      ||.:....
Worm   626 MIDTTDLVKKSWFGSLASSMSVERD--DTHCVP------VQGKTLNSIKAELIRAFLQIHELSHS 682

  Fly   867 VLDQNNCDYEQRERFVLWCVHGDPNTDSL----VQWEIEVCKLP-RLSLNG------VRFKRISG 920
            |:.| ||...:.:|       |.....|:    ::..:::...| ::.:.|      |:|..::|
Worm   683 VVGQ-NCFRVEYKR-------GPTVGGSVFSRGIKMNVDIIPSPQQVVIAGETPTYVVQFVLLAG 739

  Fly   921 TSIGFKNIASRIAFDLKLXLNQTNNEGNAAATASRPTDPTDTMTTTNCRRPSNDSTSRLSELSLL 985
            ....||.:...::..|:. ..|..:....||...||...:|:...:.|    :||.|..|.::::
Worm   740 PVRRFKRLVEHLSAILQNSTQQRADRQQQAALMVRPRRLSDSSVGSAC----SDSESNASSINMI 800

  Fly   986 CR--------SLTSQQGSQRRKKSRLSTGGSEDQKKS------------NSLLSAFQMYSPFSSK 1030
            .|        |.||..........|....|:.:..||            .|..||...|.|.||.
Worm   801 ARHSDKTETTSATSSDPYGPSPSMRSVGSGTANSYKSPTPHRRNTTAVTASSSSASNRYGPSSSS 865

  Fly  1031 ENMQSSEEVEDLHVIDTQPGHSVDVP 1056
            ....|:......|...:|..:....|
Worm   866 SGSYSNNADYSYHPEYSQRSNGSSAP 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	130/251 (52%)
		S_TKc	253..504	CDD:214567	130/250 (52%)
		UBA_MARK_Par1	525..563	CDD:270522	9/40 (23%)
		MARK1-3_C	839..936	CDD:213381	19/113 (17%)
sad-1	NP_001076760.1	STKc_BRSK1_2	45..298	CDD:270983	131/252 (52%)
		S_TKc	47..298	CDD:214567	130/250 (52%)
		UBA_BRSK	327..379	CDD:270525	12/54 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D302185at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920