Protein Alignment par-1 and kin-29

DIOPT Version :10

• Sequence 1: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Sequence 2: NP_508493.1
• Gene: kin-29 / 180574
• WormBaseID: WBGene00002210
• Length: 822
• Species: Caenorhabditis elegans
• Alignment Length: 883
• Identity: 238/883 - (26%)
• Similarity: 390/883 - (44%)
• Gaps: 144/883 - (16%)

  Fly   238 SAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVR 302
            :||.| |...|.||.|.:.:.|||||||.|::|:|.....:||||.||.:.|:..:|.||.|||:
 Worm     2 AAPRR-RMGLEKIGLYDVGRAIGKGNFATVRIARHKIAKTKVAIKSIDVSALDRENLIKLEREVK 65

  Fly   303 IMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCH 367
            |:|::|||:|||.::::..:..||::.||.|.||:::.|:..||:.|..||..|.:..|||.|.|
 Worm    66 IVKVIDHPHIVKSYEIMRVDNMLYIVSEYCSSGELYETLIEKGRVAENVARKWFSETASAVAYLH 130

  Fly   368 QKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVD 432
            .:.|:||||||||:||....||||.||||||..|....|:|:|||||||||||..|..|||.:.|
 Worm   131 SQGIVHRDLKAENILLGKNSNIKIIDFGFSNFQTGDQLLNTWCGSPPYAAPELLLGNSYDGMKAD 195

  Fly   433 VWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLET 497
            :||:||:||.||:|..||...::.:|:..||.|..:||:::|.:|.:.:||.|||||.||.:::.
 Worm   196 IWSMGVLLYILVAGGFPFPSDSVNKLKRSVLSGLVKIPYWVSVECADFIRKMLVLNPGKRYTIQN 260

  Fly   498 IMGDKWMNM--GFEEDELKPYIE--PKADL---ADPKRIEALVAMGYNR----SE---IEASLSQ 548
            ::..:||::  ..::::....:|  |.:.:   ....::...:.|...:    ||   |:|.|.:
 Worm   261 VLQHRWMHIRDDVQKNQAAQLLEAIPSSSIEIRQQSTKLNPTIMMFMQQHGKWSEEQIIDAVLGR 325

  Fly   549 VRYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNISGNDAGANAGSASVQ----SPTHRGVHRS 609
            .....:||||.||..|......:|  :|.....|   |:.....:|.|:|.    :||
 Worm   326 DFESPIFATYELLADKVKKGTLEG--TGEEFPRR---GSRGSILSGKANVDEQPLTPT------- 378

  Fly   610 ISASSTKPSRRASSGVGPTNAAATVAAATGAVGAVNPSNNYNAAGSAADRASVGSNFK-RQNTID 673
            |||........:|......:::.:.......:.::.|.|:....|:......:|:.|: |::|:.
 Worm   379 ISAHQLAQLNLSSPDCDSDDSSNSDLCDDSPMSSMGPMNHERQFGTPHGLDIIGNRFENRRHTLC 443

  Fly   674 SATIKENTARLAAQNQRPASATQKMLT---TADTTLNSPAKPR-TATKY-----DPTNGNRTVSG 729
            :      :.:|.:.|.........:|.   :.:..|..|..|. .|.::     .|......::.
 Worm   444 A------SEQLLSPNMMGQFPPPNLLLNNFSMNPPLGFPPMPEGQAAEFPLPSLHPAFATIPIAD 502

  Fly   730 TSGIIPRRSTTLYEKTSSTEKTNVIPAETNLFDRLRMASAVKSSRHFPRNVPSRSTFHSGQTRAR 794
            .|.::|...:   |:.:|..:| ::|...:|...|....|...|  || .|......:..:...:
 Worm   503 LSKMLPVPKS---ERRASAGET-LLPTNFDLTQHLANLPAPPIS--FP-TVEEEGKSYLSKYGGK 560

  Fly   795 NNTALEYSGTSGASGDSSHPGRMSFFSKLSSRFSKRPTIADEAAKPRVLRFTWSMKTTSPLMPDQ 859
            .||........|....:..|           |:.:.|.   ..|.|...|.:|:..:.|....:.
 Worm   561 RNTVHCLGNQLGGGIQNPIP-----------RYQRTPY---TKAPPAERRSSWASPSLSAQQQNH 611

  Fly   860 IMQKIREVLDQNNCDYEQRERFVLWCVHGDPNTDSLVQWEIEVCKLPRLSLNGVRFKRISGTSIG 924
            :.:..::.|..||                               .:.||      .|...|.|.|
 Worm   612 LEKLFKQALQTNN-------------------------------DMTRL------HKEFKGLSHG 639

  Fly   925 -----FKNIASRIAFDLKLXLNQTNNEGNAAATASRPTDPT-----DTMTTTNCRRP------SN 973
                 ..|..|.:|..... .::.|.:.|.|.:|| ..||.     :.......:||      |:
 Worm   640 CAQSQITNEGSSLACPQISITDEYNRQHNIAPSAS-SFDPVSIFQKNAQEVVFGQRPATAIGFSS 703

  Fly   974 DSTSRLSELSLLCRSLTSQQGSQRRKKSRLS----TGGSEDQKKSNSLLSAFQMYSPFSSKENMQ 1034
            .|.|.:|......||:..      |.:|.:.    |...::.|.|.::|..     |||....|.
 Worm   704 TSFSGMSTPEQTTRSIDD------RVRSIVCTLPFTEVIDELKASLNILKI-----PFSESHEMV 757

  Fly  1035 SSEEVEDLHVIDTQPGHSVDVPLF-------ADFSPIN 1065
            ...:|.::..:....|..:.|.:.       .:|:.||
 Worm   758 YEPQVTEMRRLSLPSGVEIGVAVLPPEHKAHVEFAIIN 795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	119/251 (47%)
		UBA_MARK_Par1	525..563	CDD:270522	12/44 (27%)
		MARK1-3_C	839..936	CDD:213381	16/101 (16%)
kin-29	NP_508493.1	Protein Kinases, catalytic domain	16..267	CDD:473864	119/250 (48%)