DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment par-1 and Mark3

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	XP_006515574.1	Gene:	Mark3 / 17169	MGIID:	1341865	Length:	806	Species:	Mus musculus

Alignment Length:	819	Identity:	443/819 - (54%)
Similarity:	539/819 - (65%)	Gaps:	103/819 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 PTVNKNVLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAPMRWRATEE-HIGKYKLIKTIGKGNFAK 266
            ||||:.....|.:|... :|..:|..|....:.|:|  :...|.|: |||.|:|:||||||||||
Mouse     8 PTVNERDTENHISHGDG-RQEVTSRTGRSGARCRNS--IASCADEQPHIGNYRLLKTIGKGNFAK 69

  Fly   267 VKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEY 331
            ||||:|:.||:||||||||||||||.|||||||||||||:|:||||||||:||||||||||||||
Mouse    70 VKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEY 134

  Fly   332 ASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGF 396
            |||||||||||.||||||||||.|||||||||||||||||:||||||||||||:::|||||||||
Mouse   135 ASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGF 199

  Fly   397 SNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRER 461
            |||||.||||||||||||||||||||||||||||||||||||||||||||||||||..|:|||||
Mouse   200 SNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRER 264

  Fly   462 VLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLADP 526
            ||||||||||||||||||||::||||||.||.:||.||.|:|:|.|.|||||||::||:.|::|.
Mouse   265 VLRGKYRIPFYMSTDCENLLKRFLVLNPVKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQ 329

  Fly   527 KRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNISGNDAGA 591
            |||:.:|.|||::.||:.|||:::||::.||||||||||.:.::..|.|.|:|||..:..|   :
Mouse   330 KRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSAELDASDSSSSSNLSLAKVRPN---S 391

  Fly   592 NAGSASVQSPTHRGVHRSISASSTKPSRRASSGVGP-------------TNAA------------ 631
            :..:::.|||.|:| .||:  ||::..||.|...||             |:.|
Mouse   392 DLSNSTGQSPHHKG-QRSV--SSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGIPSR 453

  Fly   632 ATVAAATGAVGAVNPSNNYNAAGSAADRASVGSNFK-----RQNTIDSATIKENT----ARLAA- 686
            .:.::|.|..|....|.....||: .::|.:....|     ..||......:.||    .|.||
Mouse   454 KSSSSAVGGKGIAPASPMLGNAGN-PNKADIPERKKSPAVPSSNTASGGMTRRNTYVCSERCAAD 517

  Fly   687 -----QNQRPASATQKMLTTADTTLNSPAKPRTATKYDPTNGNRTVSGTSGIIPRRSTTLYEKTS 746
                 ||.:..|.|:.....|     |||. ..||........|::|.::...|:......:...
Mouse   518 RHSVIQNGKENSLTEVFAYAA-----SPAS-LCATSTCRLRHQRSMSVSASGHPKMVLPPIDSEG 576

  Fly   747 STEKTNVIPAE-TNLFDRLRMASAVKSSR-HFPRNVPSRSTFHSGQTRARNNTALEYSGTSGASG 809
            .|.|...||.| |.:.....::||....| .|||...|||||| ||.|.|....  |:|.. ||.
Mouse   577 DTFKAIAIPDERTPVASTHSISSATTPDRIRFPRGTASRSTFH-GQPRERRTAT--YNGPP-ASP 637

  Fly   810 DSSHP----------GRMSFFSKLSSRFSKR----------PT--------------IADE---- 836
            ..||.          |..:.||||:|:.::|          ||              ::.|
Mouse   638 SLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSSEQKDE 702

  Fly   837 --AAKPRVLRFTWSMKTTSPLMPDQIMQKIREVLDQNNCDYEQRERFVLWCVHGDPNTDSLVQWE 899
              .||||.|||||||||||.:.|..:|::||:|||.|||||||||||:|:|||||.:.::|||||
Mouse   703 NREAKPRSLRFTWSMKTTSSMDPSDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWE 767

  Fly   900 IEVCKLPRLSLNGVRFKRISGTSIGFKNIASRIAFDLKL 938
            :|||||||||||||||||||||||.||||||:||.:|||
Mouse   768 MEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	222/251 (88%)
		S_TKc	253..504	CDD:214567	222/250 (89%)
		UBA_MARK_Par1	525..563	CDD:270522	21/37 (57%)
		MARK1-3_C	839..936	CDD:213381	74/96 (77%)
Mark3	XP_006515574.1	STKc_MARK	55..307	CDD:270974	222/251 (88%)
		UBA_MARK3_4	325..367	CDD:270590	23/41 (56%)
		MARK1-3_C	707..804	CDD:213381	74/96 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	460	1.000	Domainoid score	I484
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55653
Inparanoid	1	1.050	747	1.000	Inparanoid score	I579
Isobase	1	0.950	-	0	Normalized mean entropy	S1552
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	1	1.000	-	-		otm43869
orthoMCL	1	0.900	-	-		OOG6_101232
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5061
SonicParanoid	1	1.000	-	-		X401
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.700