DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment par-1 and Snrk

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_620188.1	Gene:	Snrk / 170837	RGDID:	69653	Length:	746	Species:	Rattus norvegicus

Alignment Length:	645	Identity:	191/645 - (29%)
Similarity:	293/645 - (45%)	Gaps:	130/645 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 GKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKL 315
            |.|.|.||:|:|:||.||||:|:.||::||:|:||||:|:..:...||:|||.||::.|||||:|
  Rat    14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRL 78

  Fly   316 FQVIETEKTLYLIMEYASGGEVFDYLVLHGR-MKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAE 379
            ::||:|:..||||:|...||::|||::.|.. :.|..|:..|.|||.|:.|||:..::|||||.|
  Rat    79 YEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPE 143

  Fly   380 NLL-LDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTL 443
            |:: .:.:..:|:.||||||:|.||.||.|.|||..|:|||:..|.:||.|.||:|||||||:.|
  Rat   144 NVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFML 208

  Fly   444 VSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMN--- 505
            |.|..||..:...|....::..||.:|..:|..|.:|:.:.|..:|.:|||||.|....|:.
  Rat   209 VCGQPPFQEANDSETLTMIMDCKYTVPPRVSAGCRDLITRMLQRDPKRRASLEEIESHPWLQGVD 273

  Fly   506 --------------MGFEEDELKPYIEPK--ADLADPKRIEALVAMGYNRSEIEASLSQVRYDDV 554
                          ....|:|....|:..  .|:||             |..|..:|...||:.:
  Rat   274 PSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIAD-------------RDAIVEALETNRYNHI 325

  Fly   555 FATYLLLGRKSTDPESDGSRSGSSLSLRNISGNDAGANAGSASVQS-PTHRGVHRSISASST-KP 617
            .|||.||..:....:.:......|.|..||.....         || ||...|.:.:....| .|
  Rat   326 TATYFLLAERILREKQEKEIQTRSASPSNIKAQFR---------QSWPTKIDVPQDLEDDLTATP 381

  Fly   618 SRRASSGVGPTNAAATVAAATGAVGAVNPSNN---YNAAGSAADRASVGSNFKRQNTIDSATIKE 679
            ...|:....|..|..:|.....:.|..:|:..   ...||.|.            :|:..|::|
  Rat   382 LSHATVPQSPARAGDSVLNGHRSKGLCDPAKKDELPELAGPAL------------STVPPASLK- 433

  Fly   680 NTARLAAQNQRPASATQKMLTTADTTLNSPAKPRTATKYDPTNGNRTVSGTSGIIPRRSTTLYEK 744
                       ||::.:|.|...:           ..:.:.....:.||.::.::.||..::..:
  Rat   434 -----------PAASGRKCLFRVE-----------EDEEEDEEDKKPVSLSTQVVLRRKPSVTNR 476

  Fly   745 TSSTEKTNVI-------------PAETNL---FDRLRMASAVKSSRHFPRNVPSRSTFHSGQTRA 793
            .:|.:...|:             ..:.||   ..||:|            |:.|..|.|....|.
  Rat   477 LTSRKSAPVLNQIFEEGESDDEFDMDENLPPKLSRLKM------------NIASPGTVHKRYHRR 529

  Fly   794 RNNTALEYSGTSGASGDSSHPGRMSFFSKLSSRFSKRPTIADEAAKPRVLRFTWSMKTTS 853
            ::........:|..|.|.|.              |:|....|..     |.::|..:.:|
  Rat   530 KSQGRGSSCSSSETSDDDSE--------------SRRRLDKDSG-----LAYSWHRRDSS 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	120/253 (47%)
		S_TKc	253..504	CDD:214567	120/252 (48%)
		UBA_MARK_Par1	525..563	CDD:270522	11/37 (30%)
		MARK1-3_C	839..936	CDD:213381	3/15 (20%)
Snrk	NP_620188.1	STKc_SNRK	12..269	CDD:270976	121/254 (48%)
		UBA_SNRK	288..335	CDD:270524	16/59 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..414		6/30 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	494..638		20/108 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910