Protein Alignment par-1 and Mark3

DIOPT Version :9

• Sequence 1: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Sequence 2: XP_006240625.1
• Gene: Mark3 / 170577
• RGDID: 619883
• Length: 806
• Species: Rattus norvegicus
• Alignment Length: 821
• Identity: 440/821 - (53%)
• Similarity: 535/821 - (65%)
• Gaps: 107/821 - (13%)

  Fly   203 PTVNKNVLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAPMRWRATEE-HIGKYKLIKTIGKGNFAK 266
            ||||:.....|.:|... :|..:|..|....:.|:|  :...|.|: |||.|:|:||||||||||
  Rat     8 PTVNERDTENHISHGDG-RQEVTSRTGRSGARCRNS--IASCADEQPHIGNYRLLKTIGKGNFAK 69

  Fly   267 VKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEY 331
            ||||:|:.||:||||||||||||||.|||||||||||||:|:||||||||:||||||||||||||
  Rat    70 VKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEY 134

  Fly   332 ASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGF 396
            |||||||||||.||||||||||.|||||||||||||||||:||||||||||||:::|||||||||
  Rat   135 ASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGF 199

  Fly   397 SNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRER 461
            |||||.||||||||||||||||||||||||||||||||||||||||||||||||||..|:|||||
  Rat   200 SNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRER 264

  Fly   462 VLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLADP 526
            ||||||||||||||||||||::||||||.||.:||.||.|:|:|.|.||:||||::||:.|::|.
  Rat   265 VLRGKYRIPFYMSTDCENLLKRFLVLNPVKRGTLEQIMKDRWINAGHEEEELKPFVEPELDISDQ 329

  Fly   527 KRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNI-SGNDAG 590
            |||:.:|.|||::.||:.|||:::||::.||||||||||.:.::..|.|.|:|||..: ..:|..
  Rat   330 KRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSAELDASDSSSSSNLSLAKVRPSSDLS 394

  Fly   591 ANAGSASVQSPTHRGVHRSISASSTKPSRRASSGVGPTNAAATVAA------------------- 636
            .:.|    |||.|:| .||:  ||::..||.|...||  |..:|.|
  Rat   395 NSTG----QSPHHKG-QRSV--SSSQKQRRYSDHAGP--AIPSVVAYPKRSQTSTADSDLKEDGV 450

  Fly   637 -----ATGAVG--AVNPSNNYNAAGSAADRASVGSNFK-----RQNTIDSATIKENT----ARLA 685
                 .:.|||  .:.|::......|..::|.:....|     ..|.......:.||    .|.|
  Rat   451 PSRKSGSSAVGGKGIAPASPMLGNASNPNKADIPERKKSPAVPSSNAASGGMTRRNTYVCSERCA 515

  Fly   686 A------QNQRPASATQKMLTTADTTLNSPAKPRTATKYDPTNGNRTVSGTSGIIPRRSTTLYEK 744
            |      ||.:.:|.|:.....|     |||. ..||........|::|.::...|:......:.
  Rat   516 ADRHSVIQNGKESSLTEVFAYAA-----SPAS-LCATSTCRLRHQRSMSVSASGHPKMVLPPIDS 574

  Fly   745 TSSTEKTNVIPAE-TNLFDRLRMASAVKSSR-HFPRNVPSRSTFHSGQTRARNNTALEYSGTSGA 807
            ...|.|....|.: |.:.....::||....| .|||...|||||| ||.|.|....  |:|.. |
  Rat   575 EGDTFKAITTPDQRTPVASTHSISSATTPDRIRFPRGTASRSTFH-GQPRERRTAT--YNGPP-A 635

  Fly   808 SGDSSHP----------GRMSFFSKLSSRFSKR----------PT--------------IADE-- 836
            |...||.          |..:.||||:|:.::|          ||              ::.|
  Rat   636 SPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSSEQK 700

  Fly   837 ----AAKPRVLRFTWSMKTTSPLMPDQIMQKIREVLDQNNCDYEQRERFVLWCVHGDPNTDSLVQ 897
                .||||.|||||||||||.:.|..:|::||:|||.|.|||||||||:|:|||||.:.:||||
  Rat   701 DENREAKPRSLRFTWSMKTTSSMDPSDMMREIRKVLDANTCDYEQRERFLLFCVHGDGHAESLVQ 765

  Fly   898 WEIEVCKLPRLSLNGVRFKRISGTSIGFKNIASRIAFDLKL 938
            ||:|||||||||||||||||||||||.||||||:||.:|||
  Rat   766 WEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL 806

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	222/251 (88%)
		S_TKc	253..504	CDD:214567	222/250 (89%)
		UBA_MARK_Par1	525..563	CDD:270522	21/37 (57%)
		MARK1-3_C	839..936	CDD:213381	74/96 (77%)
Mark3	XP_006240625.1	STKc_MARK	55..307	CDD:270974	222/251 (88%)
		S_TKc	56..307	CDD:214567	222/250 (89%)
		UBA_MARK3_4	325..367	CDD:270590	23/41 (56%)
		MARK1-3_C	707..804	CDD:213381	74/96 (77%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	458	1.000	Domainoid score	I465
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55653
Inparanoid	1	1.050	738	1.000	Inparanoid score	I565
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	1	1.000	-	-		otm45957
orthoMCL	1	0.900	-	-		OOG6_101232
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X401
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.860