DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment par-1 and Chek1

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	NP_536325.1	Gene:	Chek1 / 140583	RGDID:	620545	Length:	476	Species:	Rattus norvegicus

Alignment Length:	543	Identity:	145/543 - (26%)
Similarity:	229/543 - (42%)	Gaps:	115/543 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 YKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIID-KTQLN-PGSLQKLFREVRIMKMLDHPNIVKL 315
            :.|::|:|:|.:.:|:||.:..|.:.||:||:| |..:: |.:::|   |:.|.|||:|.|:||.
  Rat     9 WDLVQTLGEGAYGEVQLAVNRITEEAVAVKIVDMKRAIDCPENIKK---EICINKMLNHENVVKF 70

  Fly   316 FQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAEN 380
            :.........||.:||.||||:||.:.....|.|::|:..|.|:::.|.|.|...|.|||:|.||
  Rat    71 YGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEQDAQRFFHQLMAGVVYLHGIGITHRDIKPEN 135

  Fly   381 LLLDSELNIKIADFGFSNEFTPGSK---LDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYT 442
            ||||...|:||:|||.:..|...::   |:..||:.||.||||.:.|::....|||||.|::|..
  Rat   136 LLLDERDNLKISDFGLATVFRHNNRERLLNKMCGTLPYVAPELLKRKEFHAEPVDVWSCGIVLTA 200

  Fly   443 LVSGSLPFD--GSTLRELRERVLRGKYRIPFYMSTDCE-NLLRKFLVLNPAKRASLETIMGDKWM 504
            :::|.||:|  ..:.:|..:...:..|..|:....... .||.|.||.||:.|.::..|..|:|.
  Rat   201 MLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWY 265

  Fly   505 NMGFEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPE 569
            |        ||                     .||                      |.|.....
  Rat   266 N--------KP---------------------LNR----------------------GAKRPRAT 279

  Fly   570 SDGSRSGSSLSLRNISGN--DAGANAGSASVQSPTHRGVHRSISASSTKPSRRASSGVGPTNAAA 632
            |.|....||...::|..|  .:..|:||:          ..::..||::|..|....:..|
  Rat   280 SGGMSESSSGFSKHIHSNLDFSPINSGSS----------EENVKFSSSQPEPRTGLSLWDT---- 330

  Fly   633 TVAAATGAVGAVNPSNNYNAAGSAADRASVGSNFKRQNTIDSATIKENTARLAAQNQRPASATQK 697
                        .|||        .|:...|.:|.:....|...:..........:|.|.....|
  Rat   331 ------------GPSN--------VDKLVQGISFSQPTCPDHMLVNSQLLGTPGSSQNPWQRLVK 375

  Fly   698 MLTTADTTLNSPAK--------PRTATKYDPTNGNRTVSGTSGIIPRRSTTLYEKTSSTEKTNVI 754
            .:|...|.|::...        .:...::..:..|:....|   :.||:..|..|.:..|....|
  Rat   376 RMTRFFTKLDADKSYQCLKETFEKLGYQWKKSCMNQVTVST---MDRRNNKLIFKINLVEMDEKI 437

  Fly   755 PAETNLFD-RLRMASAVKSSRHF 776
                 |.| ||.....::..|||
  Rat   438 -----LVDFRLSKGDGLEFKRHF 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	95/258 (37%)
		S_TKc	253..504	CDD:214567	95/258 (37%)
		UBA_MARK_Par1	525..563	CDD:270522	2/37 (5%)
		MARK1-3_C	839..936	CDD:213381
Chek1	NP_536325.1	Interaction with CLSPN. /evidence=ECO:0000250	1..265		95/258 (37%)
		STKc_Chk1	7..265	CDD:270971	95/258 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..329		19/114 (17%)
		Autoinhibitory region. /evidence=ECO:0000250	391..476		15/73 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D698464at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920