Protein Alignment par-1 and Mark2

DIOPT Version :9

• Sequence 1: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Sequence 2: XP_006526704.1
• Gene: Mark2 / 13728
• MGIID: 99638
• Length: 851
• Species: Mus musculus
• Alignment Length: 907
• Identity: 426/907 - (46%)
• Similarity: 528/907 - (58%)
• Gaps: 219/907 - (24%)

  Fly   177 SSNNSAVVASSAINHHHHHTPGSGVAPTVNKNVLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAPM 241
            ||..:|.|....:.|       ....|:...|:|...::..||.:|
Mouse    19 SSKEAAGVTRPTLGH-------LDSKPSSKSNMLRGRNSATSADEQ------------------- 57

  Fly   242 RWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKM 306
                  .|||.|:|:||||||||||||||:|:.||||||:|||||||||..|||||||||||||:
Mouse    58 ------PHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKV 116

  Fly   307 LDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRI 371
            |:||||||||:||||||||||:||||||||||||||.||||||||||.|||||||||||||||.|
Mouse   117 LNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 181

  Fly   372 IHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSL 436
            :||||||||||||:::||||||||||||||.|:||||||||||||||||||||||||||||||||
Mouse   182 VHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSL 246

  Fly   437 GVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGD 501
            ||||||||||||||||..|:|||||||||||||||||||||||||:|||:|||:||.:||.||.|
Mouse   247 GVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKD 311

  Fly   502 KWMNMGFEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLLGRKST 566
            :|||:|.|:||||||:||..|..||:|.|.:|:|||.|.||:.||...||::|.|||||||.||:
Mouse   312 RWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSS 376

  Fly   567 DPESDGSRSGSSLSLRNISGNDAGANAGSASVQSPTHRGVHRSISASSTKPSRRASSGVGPTNAA 631
            :.|      |.:::|:    ....|:..::|..||:|: |.||:||:   |.:|.||
Mouse   377 ELE------GDTITLK----PRPSADLTNSSAPSPSHK-VQRSVSAN---PKQRRSS-------- 419

  Fly   632 ATVAAATGAVGAVNPSNNYNAAGSAADRASVGSNFKRQNTIDSATIKENTARLAAQNQR------ 690
                  ..||.|:..||:|             |...:.|..::...:|.|.|.|:...:
Mouse   420 ------DQAVPAIPTSNSY-------------SKKTQSNNAENKRPEEETGRKASSTAKVPASPL 465

  Fly   691 ---------PASATQKMLTTA-DTTLNSPAKPRTAT-KYDPTNG--NRTVSGT-----------S 731
                     ||.:|..:|:|: :.:.|||...|.:. :....||  :.|:.|:           |
Mouse   466 PGLDRKKTTPAPSTNSVLSTSTNRSRNSPLLDRASLGQASIQNGKDSLTMPGSRASTASASAAVS 530

  Fly   732 GIIPRR-----STTLYEKTSS----TEKTNVIPAETNLFDRLRMASA----VKSS------RHFP 777
            ...||:     |.:::...:|    ||....:|..:....|:.:||.    :.||      .:||
Mouse   531 AARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSSGAPDRTNFP 595

  Fly   778 RNVPSRSTFHSGQTR-ARNNTALEYSGTSGASGDSSHPGRM----SFFSKLSSRFSKR------- 830
            |.|.||||||:||.| .|:...|.| |.:.||......||.    |.|||.:|:|.:|
Mouse   596 RGVSSRSTFHAGQLRQVRDQQNLPY-GVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFA 659

  Fly   831 --------------------------------------------------------------PTI 833
                                                                          |..
Mouse   660 RRCRLSLPKSQELDILRQGSFCRQALVEQQEAHTLLLHLPSWDRAWLVQPGHVLCRPRNLNEPES 724

  Fly   834 ADEA----------------------AKPRVLRFTWSMKTTSPLMPDQIMQKIREVLDQNNCDYE 876
            .|..                      ||||.|||||||||||.:.|:::|::||:|||.|:|..|
Mouse   725 KDRVETLRPHVVGSGGTDKDKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSE 789

  Fly   877 QRERFVLWCVHGDPNTDSLVQWEIEVCKLPRLSLNGVRFKRISGTSIGFKNIASRIAFDLKL 938
            ..||::|.||||.|..::.||||:||||||||||||||||||||||:.||||||:||.:|||
Mouse   790 LHERYMLLCVHGTPGHENFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	218/251 (87%)
		S_TKc	253..504	CDD:214567	218/250 (87%)
		UBA_MARK_Par1	525..563	CDD:270522	22/37 (59%)
		MARK1-3_C	839..936	CDD:213381	66/96 (69%)
Mark2	XP_006526704.1	STKc_MARK	62..314	CDD:270974	218/251 (87%)
		UBA_MARK2	332..373	CDD:270589	23/40 (58%)
		MARK2_C	752..850	CDD:213386	66/97 (68%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	460	1.000	Domainoid score	I484
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	747	1.000	Inparanoid score	I579
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	1	1.000	-	-		otm43869
orthoMCL	1	0.900	-	-		OOG6_101232
Panther	1	1.100	-	-	O	PTHR24346
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5061
SonicParanoid	1	1.000	-	-		X401
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.850