Protein Alignment par-1 and Pask

DIOPT Version :10

• Sequence 1: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Sequence 2: XP_061519318.1
• Gene: Pask / 1269541
• VectorBaseID: AGAMI1_007217
• Length: 1645
• Species: Anopheles gambiae
• Alignment Length: 1196
• Identity: 270/1196 - (22%)
• Similarity: 424/1196 - (35%)
• Gaps: 356/1196 - (29%)

  Fly    17 PADSVSNGTASNVAAPAAPVSSATNAVPPLAAVSSTTATYATNSISTSSHSVKDQQQQQQQQQHD 81
            |..:.:..:....:|.||.|::||.|.||    |:.|||.::|    ||..|...::...:....
Mosquito   608 PCTTSAFASTPAASAAAAVVTAATGATPP----STATATVSSN----SSALVAGDKEVVNKCSSV 664

  Fly    82 SANANIVSLPPT--TTPVANTNTMMPIVTSSNSATSNSTAA--------------TPTPASG--- 127
            ..:.:..:||.:  .||| |.|::...:.:|.:.:.|.|.:              ..||||.
Mosquito   665 LVSEDYANLPESDLLTPV-NENSLCMNLLNSKNVSINETKSPLYTSEDINVALLKDSTPASAPPV 728

  Fly   128 ----------AAATGGVGSVSQGPATVSASAANTNHSH-QHSHQHHHHVANNMTTDGARLSSNNS 181
                      ..|.||.||:          ..:|...| :||......:...|...|.|||..:.
Mosquito   729 MVTPRFIKPYELAKGGAGSL----------VTSTPDQHKRHSAGGIADIIRQMGNAGKRLSYVDG 783

  Fly   182 AVVASSAINHHHH-----HTPGSGVAPTVNK--------------------NVLSTHSA------ 215
            . ....||::..:     :|..|.:.|...|                    ||..|.::
Mosquito   784 K-YRGEAIHYDGNVIDIIYTISSQMLPCGRKVYCIWISRDPESSYNNLEEANVTLTFNSITSTID 847

  Fly   216 ----HPSAIKQRTSSA----KGSPNMQMRSSAPMRWRATEEHI-GKYK----LIKTIGKGNFAKV 267
                .||.|...|::|    :..||     |..:..:..||.: |:|.    .||.||||.:..|
Mosquito   848 NSLGQPSKIANATAAAVTVSQSRPN-----SVSLVSQCEEEQVFGEYNKHYTTIKQIGKGAYGYV 907

  Fly   268 KLAKHLPTGKEVAIKIIDKTQLNPGSL------QKLFREVRIMKMLDHPNIVKLFQVIETEKTLY 326
            ||:........|..|.|.|.:|....:      :::..|:.::..:.|||||.:|.|.|.||...
Mosquito   908 KLSYRNTDRLLVISKFILKEKLCSNFMITTEDRKEIPMEIYLLTHVKHPNIVTVFDVFENEKFFQ 972

  Fly   327 LIME-YASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIK 390
            |:|| :.||.::|:::.....|.||.....||||.:||.|.|...|:|||:|.||:::|...::|
Mosquito   973 LVMEVHGSGMDLFEFIDRRPAMTEKLGCYIFRQIANAVDYLHSLNILHRDIKDENIIIDQHFHVK 1037

  Fly   391 IADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTL 455
            :.|||.:.....|....||.|:..|.:||:..|.||.|||:::|||||.||.|:....||...
Mosquito  1038 LIDFGSATFMQEGKLFSTFYGTTEYCSPEVLAGNKYAGPELEMWSLGVTLYVLMFFENPFLDI-- 1100

  Fly   456 RELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKP----- 515
                |..|:.:..||..:|.:.|.:|...|..||..|.:::.::..:|:.     .|:.|
Mosquito  1101 ----EETLKSELIIPQEISPELEYVLLSLLDKNPKTRITMKQLICTEWLT-----QEINPSAFNF 1156

  Fly   516 -YIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPESDGSRSGSSL 579
             :|.|    .:|..:.   ...|...:|.:|.:.:               ||.|.        ||
Mosquito  1157 AHIVP----CEPYEVN---PEKYFNGQIYSSQTGL---------------STSPH--------SL 1191

  Fly   580 SLRNISGNDAGANAGSASVQSPTHRGVHRSISASSTKPSRRASSGVGPTNAAATVAAATGAVGAV 644
            ||  :...|.|   .......|     |..|..|...|.......:.|.
Mosquito  1192 SL--VDDEDEG---DDEEEDEP-----HAHIDDSFVDPDELQDDDICPL---------------- 1230

  Fly   645 NPSNNYNAAGSAADRASVGSNFKRQNTIDSATIKENTARLAAQNQRPASATQKMLTTADTTLNSP 709
                                      |.|...:.|.:..|.:..:..|:.|  :|......| |.
Mosquito  1231 --------------------------THDDEKLPERSYELCSGRETHAAGT--ILAKGIQNL-SL 1266

  Fly   710 AKPRTATKYDPTNGNRTVSGTSGIIPRRSTTLYEKTSSTEKTNVIPAETNLFDRLRMASAVKSSR 774
            .:|.|...:..|..  |.:..||:|            .|..:|...|
Mosquito  1267 QEPSTCNNHSSTID--TTAAVSGVI------------GTGNSNACYA------------------ 1299

  Fly   775 HFPRNVPSRSTFHSGQTRAR----NNTALEYSGTSGASGDSSHPGRMSFFSKLSSRFSKRPT--- 832
            :...:||...::..|.::|.    |.:..:..|..||.|..:........|..:|..|..|.
Mosquito  1300 YAEHSVPVVVSYFGGGSQANPSLVNMSPADCGGAGGADGSGNIESNAISISTAASSSSSIPVQCV 1364

  Fly   833 -------------IADEAAK----------PRVLRFTWSMKTTSPLMPDQIM-------QKIREV 867
                         :.:.||.          |||...:.::..:..|:|.|.:       |..|..
Mosquito  1365 SECVYKPSTFECDVVERAASLVGATDAERIPRVGSVSTAIVNSPSLLPLQTIACEETARQAYRRS 1429

  Fly   868 LDQNNCDYEQRERFVLWCVHGDPNTDSLV---QWEIEVC-KLPRLSLNGVRFKRISGTSI--GFK 926
            ..|:.||..        |    ..|.||.   ...:.:| .:|...||       ||.|.  ...
Mosquito  1430 NRQSMCDSS--------C----STTPSLALPPSSSVLMCTMMPYSVLN-------SGDSCCSSVT 1475

  Fly   927 NIASRIAF-DLKLXLNQTNNEGNAAATASRPTDPTDTMTTTNCRRPSNDSTSRLSELSLLCRSLT 990
            .::|..:| |..| .:..::...:::.|..|         |||                 |
Mosquito  1476 TMSSCCSFEDHHLHFHYPDDSTASSSAADTP---------TNC-----------------C---- 1510

  Fly   991 SQQGSQRR--KKSRLSTGGSEDQKKSNSLLSAFQMY-------SPFSSKENMQSSEEVEDLHVID 1046
            ||:..|.:  .||.|...|:.|...:|.||...:.|       ||.||..:.:|...:.|
Mosquito  1511 SQELPQTQICTKSVLPKKGTYDDASANLLLLDARHYAASSSSTSPCSSLTSSKSENNIFD----- 1570

  Fly  1047 TQPGHSVDVPLFADFSPINPIMEEDA 1072
               |:      ||.||.|..::..|:
Mosquito  1571 ---GN------FATFSSIYDVVSMDS 1587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	89/262 (34%)
		UBA_MARK_Par1	525..563	CDD:270522	4/37 (11%)
		MARK1-3_C	839..936	CDD:213381	24/120 (20%)
Pask	XP_061519318.1	None