DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment par-1 and CHEK1

DIOPT Version :9

Sequence 1:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster
Sequence 2:	XP_011540862.1	Gene:	CHEK1 / 1111	HGNCID:	1925	Length:	492	Species:	Homo sapiens

Alignment Length:	447	Identity:	109/447 - (24%)
Similarity:	172/447 - (38%)	Gaps:	110/447 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   347 MKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSK---LDT 408
            |.|.:|:..|.|:::.|.|.|...|.|||:|.||||||...|:||:|||.:..|...::   |:.
Human   118 MPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNK 182

  Fly   409 FCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFD--GSTLRELRERVLRGKYRIPF 471
            .||:.||.||||.:.:::....|||||.|::|..:::|.||:|  ..:.:|..:...:..|..|:
Human   183 MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPW 247

  Fly   472 YMSTDCE-NLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLADPKRIEALVAM 535
            ....... .||.|.||.||:.|.::..|..|:|.|        ||
Human   248 KKIDSAPLALLHKILVENPSARITIPDIKKDRWYN--------KP-------------------- 284

  Fly   536 GYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPESDG-SRSGSSLSLRNISGNDAGANAGSASVQ 599
                                   |..|.|.....|.| |.|.|..| ::|..|...:...|||.:
Human   285 -----------------------LKKGAKRPRVTSGGVSESPSGFS-KHIQSNLDFSPVNSASSE 325

  Fly   600 SPTHRGVHRSISASSTKPSRRASSGVGPTNAAATVAAATGAVGAVNPSNNYNAAGSAADRASVGS 664
                    .::..||::|..|....:                        ::.:.|..|:...|.
Human   326 --------ENVKYSSSQPEPRTGLSL------------------------WDTSPSYIDKLVQGI 358

  Fly   665 NFKRQNTIDSATIKENTARLAAQNQRPASATQKMLTTADTTLNSPAK--------PRTATKYDPT 721
            :|.:....|...:..........:|.|.....|.:|...|.|::...        .:...::..:
Human   359 SFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKS 423

  Fly   722 NGNR-TVSGTSGIIPRRSTTLYEKTSSTEKTNVIPAETNLFD-RLRMASAVKSSRHF 776
            ..|: |:|.|.    ||:..|..|.:..|..:.|     |.| ||.....::..|||
Human   424 CMNQVTISTTD----RRNNKLIFKVNLLEMDDKI-----LVDFRLSKGDGLEFKRHF 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	59/162 (36%)
		S_TKc	253..504	CDD:214567	59/162 (36%)
		UBA_MARK_Par1	525..563	CDD:270522	1/37 (3%)
		MARK1-3_C	839..936	CDD:213381
CHEK1	XP_011540862.1	PKc_like	<114..281	CDD:304357	59/162 (36%)
CHEK1	XP_011540862.1	S_TKc	<117..280	CDD:214567	59/161 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D698464at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920